Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin Coatings
The release of insulin from insulin-containing CaCO3 microspheres was investigated. The microspheres were prepared by mixing aqueous solutions of CaCl2 and Na2CO3 in the presence of insulin. The surface of the insulin-containing CaCO3 microspheres was coated with a layer-by-layer thin film consisti...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-08-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4360/6/8/2157 |
| _version_ | 1811209510574882816 |
|---|---|
| author | Katsuhiko Sato Masaru Seno Jun-Ichi Anzai |
| author_facet | Katsuhiko Sato Masaru Seno Jun-Ichi Anzai |
| author_sort | Katsuhiko Sato |
| collection | DOAJ |
| description | The release of insulin from insulin-containing CaCO3 microspheres was investigated. The microspheres were prepared by mixing aqueous solutions of CaCl2 and Na2CO3 in the presence of insulin. The surface of the insulin-containing CaCO3 microspheres was coated with a layer-by-layer thin film consisting of poly(allylamine hydrochloride) and poly(styrene sulfonate) to regulate the release kinetics of insulin. The release rate of insulin from the coated CaCO3 microspheres was significantly suppressed compared with that of uncoated CaCO3 microspheres, and depended on the thickness of the films. Rhombohedral calcite crystals of CaCO3 formed from the microspheres during the release of insulin, suggesting that the CaCO3 microspheres dissolved and recrystallized during the release of insulin. |
| first_indexed | 2024-04-12T04:40:43Z |
| format | Article |
| id | doaj.art-fb3d3e7cfde14f659e711e5ed9714924 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-04-12T04:40:43Z |
| publishDate | 2014-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-fb3d3e7cfde14f659e711e5ed97149242022-12-22T03:47:40ZengMDPI AGPolymers2073-43602014-08-01682157216510.3390/polym6082157polym6082157Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin CoatingsKatsuhiko Sato0Masaru Seno1Jun-Ichi Anzai2Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, JapanGraduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, JapanGraduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, JapanThe release of insulin from insulin-containing CaCO3 microspheres was investigated. The microspheres were prepared by mixing aqueous solutions of CaCl2 and Na2CO3 in the presence of insulin. The surface of the insulin-containing CaCO3 microspheres was coated with a layer-by-layer thin film consisting of poly(allylamine hydrochloride) and poly(styrene sulfonate) to regulate the release kinetics of insulin. The release rate of insulin from the coated CaCO3 microspheres was significantly suppressed compared with that of uncoated CaCO3 microspheres, and depended on the thickness of the films. Rhombohedral calcite crystals of CaCO3 formed from the microspheres during the release of insulin, suggesting that the CaCO3 microspheres dissolved and recrystallized during the release of insulin.http://www.mdpi.com/2073-4360/6/8/2157herepolymer coatingcalcium carbonateinsulin deliverylayer-by-layer filmcontrolled release |
| spellingShingle | Katsuhiko Sato Masaru Seno Jun-Ichi Anzai Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin Coatings Polymers here polymer coating calcium carbonate insulin delivery layer-by-layer film controlled release |
| title | Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin Coatings |
| title_full | Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin Coatings |
| title_fullStr | Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin Coatings |
| title_full_unstemmed | Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin Coatings |
| title_short | Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin Coatings |
| title_sort | release of insulin from calcium carbonate microspheres with and without layer by layer thin coatings |
| topic | here polymer coating calcium carbonate insulin delivery layer-by-layer film controlled release |
| url | http://www.mdpi.com/2073-4360/6/8/2157 |
| work_keys_str_mv | AT katsuhikosato releaseofinsulinfromcalciumcarbonatemicrosphereswithandwithoutlayerbylayerthincoatings AT masaruseno releaseofinsulinfromcalciumcarbonatemicrosphereswithandwithoutlayerbylayerthincoatings AT junichianzai releaseofinsulinfromcalciumcarbonatemicrosphereswithandwithoutlayerbylayerthincoatings |