Focused ultrasound: a novel therapy for improving vaginal microecology in patients with high-risk HPV infection
AbstractObjectives To investigate changes in vaginal microecology in women with high-risk human papillomavirus (HR-HPV) infection after focused ultrasound (FU) treatment.Materials and methods We collected vaginal secretions at the time of admission and 3 months after FU treatment from 169 women who...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2211276 |
| _version_ | 1797374264235524096 |
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| author | Hua Tao Dingyuan Zeng Wenzhi Chen Fang Li Haijing Zhong Jinjian Fu Hanzhi Liu Ting Ying Li Wang Jing Chen Zhibiao Wang Qiuling Shi |
| author_facet | Hua Tao Dingyuan Zeng Wenzhi Chen Fang Li Haijing Zhong Jinjian Fu Hanzhi Liu Ting Ying Li Wang Jing Chen Zhibiao Wang Qiuling Shi |
| author_sort | Hua Tao |
| collection | DOAJ |
| description | AbstractObjectives To investigate changes in vaginal microecology in women with high-risk human papillomavirus (HR-HPV) infection after focused ultrasound (FU) treatment.Materials and methods We collected vaginal secretions at the time of admission and 3 months after FU treatment from 169 women who received FU treatment for cervical HR-HPV infection between July 2020 and September 2022. Among them, there were 101 patients with cute vaginitis, we also collected their vaginal secretions after one week of drug treatment. These samples were evaluated for vaginal microecology and HPV-DNA examination.Results Of the 169 patients, 101 (59.7%) suffered from acute vaginitis at the time of admission. After one week of targeted antibiotics drug treatment, there were no pathogens or pus cells on the field of microscopic vision, but there was no significant difference(p > 0.05) in the diversity and density of vaginal flora, the proportion and function of Lactobacillus (H2O2 negative rate) between one week after treatment and at the time of admission. At the time of admission of the 169 patients, the normal flora rate was 40.3%, which increased to 93.5% three months after FU treatment. The differences in vaginal secretion parameters at the time of admission and 3 months after FU treatment were as follows: H2O2 negative rate (37.3% vs. 3.6%), leukocyte esterase positive rate (54.4% vs. 5.9%), sialidase positive rate (38.5% vs. 4.1%), bacterial vaginitis positive rate (55% vs. 4.7%), fungal vaginitis positive rate (44.4% vs. 5.9%), and trichomonal vaginitis positive rate (7.1% vs. 0). The difference was statistically significant (p < 0.01). The pH value and Nagent score at the time of admission were significantly higher than those three months after FU. Three months after FU, the positive rate of HPV was 5.8% in the group of patients with normal vaginal microecology at the time of admission and post-FU; it was 6.7% in the group of patients with abnormal vaginal microecology at the time of admission and normal vaginal microecology post-FU; and it was 100% in the group patients with abnormal vaginal microecology at the time of admission and post-FU. A significant difference was observed among the three groups (p < 0.01).Conclusion FU is an effective treatment for patients with cervical HR-HPV infection. FU does not interfere with the vaginal microecology of HR-HPV positive patients with normal vaginal microecology.FU followed by antibiotic drug therapy for pathogens is beneficial to restore the function of Lactobacillus vaginalis in HR-HPV positive patients with acute vaginitis,so as to improve the vaginal microecology of HR-HPV positive patients with abnormal vaginal microecology. |
| first_indexed | 2024-03-08T19:03:21Z |
| format | Article |
| id | doaj.art-fb3d9c662f0744da8009daaf95745893 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T19:03:21Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-fb3d9c662f0744da8009daaf957458932023-12-28T04:15:43ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572023-12-0140110.1080/02656736.2023.2211276Focused ultrasound: a novel therapy for improving vaginal microecology in patients with high-risk HPV infectionHua Tao0Dingyuan Zeng1Wenzhi Chen2Fang Li3Haijing Zhong4Jinjian Fu5Hanzhi Liu6Ting Ying7Li Wang8Jing Chen9Zhibiao Wang10Qiuling Shi11State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, P. R. ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Prevention and Protection, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, P. R. ChinaDepartment of Gynecology, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, P. R. ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaAbstractObjectives To investigate changes in vaginal microecology in women with high-risk human papillomavirus (HR-HPV) infection after focused ultrasound (FU) treatment.Materials and methods We collected vaginal secretions at the time of admission and 3 months after FU treatment from 169 women who received FU treatment for cervical HR-HPV infection between July 2020 and September 2022. Among them, there were 101 patients with cute vaginitis, we also collected their vaginal secretions after one week of drug treatment. These samples were evaluated for vaginal microecology and HPV-DNA examination.Results Of the 169 patients, 101 (59.7%) suffered from acute vaginitis at the time of admission. After one week of targeted antibiotics drug treatment, there were no pathogens or pus cells on the field of microscopic vision, but there was no significant difference(p > 0.05) in the diversity and density of vaginal flora, the proportion and function of Lactobacillus (H2O2 negative rate) between one week after treatment and at the time of admission. At the time of admission of the 169 patients, the normal flora rate was 40.3%, which increased to 93.5% three months after FU treatment. The differences in vaginal secretion parameters at the time of admission and 3 months after FU treatment were as follows: H2O2 negative rate (37.3% vs. 3.6%), leukocyte esterase positive rate (54.4% vs. 5.9%), sialidase positive rate (38.5% vs. 4.1%), bacterial vaginitis positive rate (55% vs. 4.7%), fungal vaginitis positive rate (44.4% vs. 5.9%), and trichomonal vaginitis positive rate (7.1% vs. 0). The difference was statistically significant (p < 0.01). The pH value and Nagent score at the time of admission were significantly higher than those three months after FU. Three months after FU, the positive rate of HPV was 5.8% in the group of patients with normal vaginal microecology at the time of admission and post-FU; it was 6.7% in the group of patients with abnormal vaginal microecology at the time of admission and normal vaginal microecology post-FU; and it was 100% in the group patients with abnormal vaginal microecology at the time of admission and post-FU. A significant difference was observed among the three groups (p < 0.01).Conclusion FU is an effective treatment for patients with cervical HR-HPV infection. FU does not interfere with the vaginal microecology of HR-HPV positive patients with normal vaginal microecology.FU followed by antibiotic drug therapy for pathogens is beneficial to restore the function of Lactobacillus vaginalis in HR-HPV positive patients with acute vaginitis,so as to improve the vaginal microecology of HR-HPV positive patients with abnormal vaginal microecology.https://www.tandfonline.com/doi/10.1080/02656736.2023.2211276Focused ultrasoundHR-HPV infectioncervixvaginal microecology |
| spellingShingle | Hua Tao Dingyuan Zeng Wenzhi Chen Fang Li Haijing Zhong Jinjian Fu Hanzhi Liu Ting Ying Li Wang Jing Chen Zhibiao Wang Qiuling Shi Focused ultrasound: a novel therapy for improving vaginal microecology in patients with high-risk HPV infection International Journal of Hyperthermia Focused ultrasound HR-HPV infection cervix vaginal microecology |
| title | Focused ultrasound: a novel therapy for improving vaginal microecology in patients with high-risk HPV infection |
| title_full | Focused ultrasound: a novel therapy for improving vaginal microecology in patients with high-risk HPV infection |
| title_fullStr | Focused ultrasound: a novel therapy for improving vaginal microecology in patients with high-risk HPV infection |
| title_full_unstemmed | Focused ultrasound: a novel therapy for improving vaginal microecology in patients with high-risk HPV infection |
| title_short | Focused ultrasound: a novel therapy for improving vaginal microecology in patients with high-risk HPV infection |
| title_sort | focused ultrasound a novel therapy for improving vaginal microecology in patients with high risk hpv infection |
| topic | Focused ultrasound HR-HPV infection cervix vaginal microecology |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2211276 |
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