microRNA-132 regulates gene expression programs involved in microglial homeostasis

microRNA-132 regulates gene expression programs involved in microglial homeostasis

Summary: microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly downregulated microRNAs (miRNAs) in the brain of Alzheimer’s disease (AD) patients. Increasing miR-132 in AD mouse brain ameliorates amyloid and Tau pathologies, and also restores adult hippocampal neurogenesis...

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Bibliographic Details
Main Authors: Hannah Walgrave, Amber Penning, Giorgia Tosoni, Sarah Snoeck, Kristofer Davie, Emma Davis, Leen Wolfs, Annerieke Sierksma, Mayte Mars, Taofeng Bu, Nicola Thrupp, Lujia Zhou, Diederik Moechars, Renzo Mancuso, Mark Fiers, Andrew J.M. Howden, Bart De Strooper, Evgenia Salta
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Molecular biology
Neuroscience
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223009069

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