VCP Machinery Mediates Autophagic Degradation of Empty Argonaute

VCP Machinery Mediates Autophagic Degradation of Empty Argonaute

Summary: The Argonaute subfamily of proteins (AGO) loads microRNAs (miRNAs) to form the effector complex that mediates target gene silencing. Empty AGO, but not miRNA-loaded AGO, is selectively degraded across species. We have reported that the degradation of empty AGO is part of a quality control p...

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Bibliographic Details
Main Authors:	Hotaka Kobayashi, Keisuke Shoji, Kaori Kiyokawa, Lumi Negishi, Yukihide Tomari
Format:	Article
Language:	English
Published:	Elsevier 2019-07-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124719308873

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