Anti-Influenza Virus Study of Composite Material with MIL-101(Fe)-Adsorbed Favipiravir
Nanomaterial technology has attracted much attention because of its antibacterial and drug delivery properties, among other applications. Metal-organic frameworks (MOFs) have advantages, such as their pore structure, large specific surface area, open metal sites, and chemical stability, over other n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/7/2288 |
| _version_ | 1827623034979090432 |
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| author | Mengyuan Xu Xi Li Huiying Zheng Jiehan Chen Xiaohua Ye Tiantian Liu |
| author_facet | Mengyuan Xu Xi Li Huiying Zheng Jiehan Chen Xiaohua Ye Tiantian Liu |
| author_sort | Mengyuan Xu |
| collection | DOAJ |
| description | Nanomaterial technology has attracted much attention because of its antibacterial and drug delivery properties, among other applications. Metal-organic frameworks (MOFs) have advantages, such as their pore structure, large specific surface area, open metal sites, and chemical stability, over other nanomaterials, enabling better drug encapsulation and adsorption. In two examples, we used the common pathogenic bacterium <i>Staphylococcus aureus</i> and highly infectious influenza A virus. A novel complex MIL-101(Fe)-T705 was formed by synthesizing MOF material MIL-101(Fe) with the drug favipiravir (T-705), and a hot solvent synthesis method was applied to investigate the in vitro antibacterial and antiviral activities. The results showed that MIL-101(Fe)-T705 combined the advantages of nanomaterials and drugs and could inhibit the growth of <i>Staphylococcus aureus</i> at a concentration of 0.0032 g/mL. Regarding the inhibition of influenza A virus, MIL-101(Fe)-T705 showed good biosafety at 12, 24, 48, and 72 h in addition to a good antiviral effect at concentrations of 0.1, 0.2, 0.4, 0.8, 1.6, and 3 μg/mL, which were higher than MIL-101(Fe) and T-705. |
| first_indexed | 2024-03-09T11:36:35Z |
| format | Article |
| id | doaj.art-fb41ee15c44e42d785882c4052410fc8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:36:35Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fb41ee15c44e42d785882c4052410fc82023-11-30T23:42:11ZengMDPI AGMolecules1420-30492022-03-01277228810.3390/molecules27072288Anti-Influenza Virus Study of Composite Material with MIL-101(Fe)-Adsorbed FavipiravirMengyuan Xu0Xi Li1Huiying Zheng2Jiehan Chen3Xiaohua Ye4Tiantian Liu5School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, ChinaNanomaterial technology has attracted much attention because of its antibacterial and drug delivery properties, among other applications. Metal-organic frameworks (MOFs) have advantages, such as their pore structure, large specific surface area, open metal sites, and chemical stability, over other nanomaterials, enabling better drug encapsulation and adsorption. In two examples, we used the common pathogenic bacterium <i>Staphylococcus aureus</i> and highly infectious influenza A virus. A novel complex MIL-101(Fe)-T705 was formed by synthesizing MOF material MIL-101(Fe) with the drug favipiravir (T-705), and a hot solvent synthesis method was applied to investigate the in vitro antibacterial and antiviral activities. The results showed that MIL-101(Fe)-T705 combined the advantages of nanomaterials and drugs and could inhibit the growth of <i>Staphylococcus aureus</i> at a concentration of 0.0032 g/mL. Regarding the inhibition of influenza A virus, MIL-101(Fe)-T705 showed good biosafety at 12, 24, 48, and 72 h in addition to a good antiviral effect at concentrations of 0.1, 0.2, 0.4, 0.8, 1.6, and 3 μg/mL, which were higher than MIL-101(Fe) and T-705.https://www.mdpi.com/1420-3049/27/7/2288MIL-101(Fe)favipiravirantibacteriaantiviral |
| spellingShingle | Mengyuan Xu Xi Li Huiying Zheng Jiehan Chen Xiaohua Ye Tiantian Liu Anti-Influenza Virus Study of Composite Material with MIL-101(Fe)-Adsorbed Favipiravir Molecules MIL-101(Fe) favipiravir antibacteria antiviral |
| title | Anti-Influenza Virus Study of Composite Material with MIL-101(Fe)-Adsorbed Favipiravir |
| title_full | Anti-Influenza Virus Study of Composite Material with MIL-101(Fe)-Adsorbed Favipiravir |
| title_fullStr | Anti-Influenza Virus Study of Composite Material with MIL-101(Fe)-Adsorbed Favipiravir |
| title_full_unstemmed | Anti-Influenza Virus Study of Composite Material with MIL-101(Fe)-Adsorbed Favipiravir |
| title_short | Anti-Influenza Virus Study of Composite Material with MIL-101(Fe)-Adsorbed Favipiravir |
| title_sort | anti influenza virus study of composite material with mil 101 fe adsorbed favipiravir |
| topic | MIL-101(Fe) favipiravir antibacteria antiviral |
| url | https://www.mdpi.com/1420-3049/27/7/2288 |
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