Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh.
There is lack of information on the histological characteristics of the intestinal mucosa in Bangladeshi children. Collection of intestinal biopsy samples and assessment of the histomorphological features is considered to be the traditional gold standard for diagnosis of environmental enteric dysfun...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0010472 |
| _version_ | 1797905298302697472 |
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| author | Md Shabab Hossain S M Khodeza Nahar Begum M Masudur Rahman Mashud Parvez Ramendra Nath Mazumder Shafiqul Alam Sarker Md Mehedi Hasan Shah Mohammad Fahim Md Amran Gazi Subhasish Das Mustafa Mahfuz Tahmeed Ahmed |
| author_facet | Md Shabab Hossain S M Khodeza Nahar Begum M Masudur Rahman Mashud Parvez Ramendra Nath Mazumder Shafiqul Alam Sarker Md Mehedi Hasan Shah Mohammad Fahim Md Amran Gazi Subhasish Das Mustafa Mahfuz Tahmeed Ahmed |
| author_sort | Md Shabab Hossain |
| collection | DOAJ |
| description | There is lack of information on the histological characteristics of the intestinal mucosa in Bangladeshi children. Collection of intestinal biopsy samples and assessment of the histomorphological features is considered to be the traditional gold standard for diagnosis of environmental enteric dysfunction (EED). The purpose of the study was to evaluate the intestinal histological characteristics of stunted children aged between 12-18 months with possible EED. 110 children with chronic malnutrition (52 stunted with length-for-age Z score, LAZ<-2 and 58 at risk of stunting with LAZ <-1 to -2) from the Bangladesh Environmental Enteric Dysfunction (BEED) study protocol who underwent upper gastrointestinal (GI) endoscopy were selected for this study. To explore the association of EED with childhood stunting, upper GI endoscopy was done and the biopsy specimens were studied for histopathology. Villous height and crypt depth were measured and the presence and intensity of inflammatory infiltrates in the lamina propria was investigated. Bivariate analysis was performed to examine the relationship between stunting and histologic morphology. More than 90% children irrespective of nutritional status were diagnosed to have chronic non-specific duodenitis on histopathology. Half of the children from both groups had villous atrophy as well as crypt hyperplasia and lymphocytic infiltration was present in more than 90% children, irrespective of groups. However, no statistically significant difference was observed when compared between the groups. The prevalence of chronic non-specific duodenitis in Bangladeshi children, irrespective of nutritional status, was high. A significant number of these children had abnormal findings in intestinal histomorphology. Trial registration number: ClinicalTrials.gov ID: NCT02812615 Date of first registration: 24/06/2016. https://clinicaltrials.gov/ct2/results?cond=NCT02812615&term=&cntry=&state=&city=&dist. |
| first_indexed | 2024-04-10T10:02:57Z |
| format | Article |
| id | doaj.art-fb436f0a5a6c49beb59864ef7213d2b4 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-10T10:02:57Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-fb436f0a5a6c49beb59864ef7213d2b42023-02-16T05:32:35ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352023-01-01171e001047210.1371/journal.pntd.0010472Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh.Md Shabab HossainS M Khodeza Nahar BegumM Masudur RahmanMashud ParvezRamendra Nath MazumderShafiqul Alam SarkerMd Mehedi HasanShah Mohammad FahimMd Amran GaziSubhasish DasMustafa MahfuzTahmeed AhmedThere is lack of information on the histological characteristics of the intestinal mucosa in Bangladeshi children. Collection of intestinal biopsy samples and assessment of the histomorphological features is considered to be the traditional gold standard for diagnosis of environmental enteric dysfunction (EED). The purpose of the study was to evaluate the intestinal histological characteristics of stunted children aged between 12-18 months with possible EED. 110 children with chronic malnutrition (52 stunted with length-for-age Z score, LAZ<-2 and 58 at risk of stunting with LAZ <-1 to -2) from the Bangladesh Environmental Enteric Dysfunction (BEED) study protocol who underwent upper gastrointestinal (GI) endoscopy were selected for this study. To explore the association of EED with childhood stunting, upper GI endoscopy was done and the biopsy specimens were studied for histopathology. Villous height and crypt depth were measured and the presence and intensity of inflammatory infiltrates in the lamina propria was investigated. Bivariate analysis was performed to examine the relationship between stunting and histologic morphology. More than 90% children irrespective of nutritional status were diagnosed to have chronic non-specific duodenitis on histopathology. Half of the children from both groups had villous atrophy as well as crypt hyperplasia and lymphocytic infiltration was present in more than 90% children, irrespective of groups. However, no statistically significant difference was observed when compared between the groups. The prevalence of chronic non-specific duodenitis in Bangladeshi children, irrespective of nutritional status, was high. A significant number of these children had abnormal findings in intestinal histomorphology. Trial registration number: ClinicalTrials.gov ID: NCT02812615 Date of first registration: 24/06/2016. https://clinicaltrials.gov/ct2/results?cond=NCT02812615&term=&cntry=&state=&city=&dist.https://doi.org/10.1371/journal.pntd.0010472 |
| spellingShingle | Md Shabab Hossain S M Khodeza Nahar Begum M Masudur Rahman Mashud Parvez Ramendra Nath Mazumder Shafiqul Alam Sarker Md Mehedi Hasan Shah Mohammad Fahim Md Amran Gazi Subhasish Das Mustafa Mahfuz Tahmeed Ahmed Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. PLoS Neglected Tropical Diseases |
| title | Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
| title_full | Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
| title_fullStr | Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
| title_full_unstemmed | Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
| title_short | Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
| title_sort | environmental enteric dysfunction and small intestinal histomorphology of stunted children in bangladesh |
| url | https://doi.org/10.1371/journal.pntd.0010472 |
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