A Comparative Assessment of Serum Malondialdehyde Level and Paraoxonase Activity in Healthy and Kwashiorkor Children
Introduction: Malnutrition is associated with increased oxidative stress. Increased oxidative stress can change the cellular function in many diseases including protein energy malnutrition. Aim: To compare serum malondialdehyde level and paraoxonase activity in healthy and kwashiorkor children....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2017-04-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2209/24075_CE[VSU]_F(GH)_PF1(VsuGH)_PFA_NC(GH)_PF2(VsuGH).pdf |
| Summary: | Introduction: Malnutrition is associated with increased
oxidative stress. Increased oxidative stress can change the
cellular function in many diseases including protein energy
malnutrition.
Aim: To compare serum malondialdehyde level and
paraoxonase activity in healthy and kwashiorkor children.
Materials and Methods: This case-control study was done
to assess the serum level of Paraoxonase 1 (PON1) and
Malondialdehyde (MDA) level in kwashiorkor (as cases) and
healthy children (as control). Serum MDA levels and PON1
levels were measured spectrophotometrically.
Results: The level of MDA was significantly increased in
kwashiorkor children (p<0.001) and PON 1 activity was
significantly decreased in kwashiorkor children (p<0.001)
Conclusion: The study concluded that increased oxidative
stress results in decreased antioxidant system. Hence,
children suffering from malnutrition should be given antioxidant
supplement so as to reduce the severity of the disease. |
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| ISSN: | 2277-8551 2455-6882 |