Supramolecular Gels Incorporating <i>Cordyline terminalis</i> Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications
<i>Cordyline terminalis</i> leaf extract (aqCT) possesses abundant polyphenols and other bioactive compounds, which are encapsulated in gelatin–polyethylene glycol–tyramine (GPT)/alpha-cyclodextrin (α-CD) gels to form the additional functional materials for biomedical applications. In th...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/8759 |
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| author | Dieu Phuong Nguyen Thi Dieu Linh Tran Phuong Le Thi Ki Dong Park Thai Thanh Hoang Thi |
| author_facet | Dieu Phuong Nguyen Thi Dieu Linh Tran Phuong Le Thi Ki Dong Park Thai Thanh Hoang Thi |
| author_sort | Dieu Phuong Nguyen Thi |
| collection | DOAJ |
| description | <i>Cordyline terminalis</i> leaf extract (aqCT) possesses abundant polyphenols and other bioactive compounds, which are encapsulated in gelatin–polyethylene glycol–tyramine (GPT)/alpha-cyclodextrin (α-CD) gels to form the additional functional materials for biomedical applications. In this study, the gel compositions are optimized, and the GPT/α-CD ratios equal to or less than one half for solidification are found. The gelation time varies from 40.7 min to 5.0 h depending on the increase in GPT/α-CD ratios and aqCT amount. The aqCT extract disturbs the hydrogen bonding and host–guest inclusion of GPT/α-CD gel networks, postponing the gelation. Scanning electron microscope observation shows that all gels with or without aqCT possess a microarchitecture and porosity. GPT/α-CD/aqCT gels could release polyphenols from 110 to 350 nmol/mL at the first hour and sustainably from 5.5 to 20.2 nmol/mL for the following hours, which is controlled by feeding the aqCT amount and gel properties. GPT/α-CD/aqCT gels achieved significant antioxidant activity through a 100% scavenging DPPH radical. In addition, all gels are non-cytotoxic with a cell viability more than 85%. Especially, the GPT3.75α-CD10.5aqCT gels with aqCT amount of 3.1–12.5 mg/mL immensely enhanced the cell proliferation of GPT3.75α-CD10.5 gel without extract. These results suggest that the inherent bioactivities of aqCT endowed the resulting GPT/α-CD/aqCT gels with effective antioxidant and high biocompatibility, and natural polyphenols sustainably release a unique platform for a drug delivery system or other biomedical applications. |
| first_indexed | 2024-03-10T08:45:23Z |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:45:23Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fb45650f72104641bfbda77b68c1e6692023-11-22T08:00:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216875910.3390/ijms22168759Supramolecular Gels Incorporating <i>Cordyline terminalis</i> Leaf Extract as a Polyphenol Release Scaffold for Biomedical ApplicationsDieu Phuong Nguyen Thi0Dieu Linh Tran1Phuong Le Thi2Ki Dong Park3Thai Thanh Hoang Thi4Biomaterials and Nanotechnology Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, VietnamDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaBiomaterials and Nanotechnology Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam<i>Cordyline terminalis</i> leaf extract (aqCT) possesses abundant polyphenols and other bioactive compounds, which are encapsulated in gelatin–polyethylene glycol–tyramine (GPT)/alpha-cyclodextrin (α-CD) gels to form the additional functional materials for biomedical applications. In this study, the gel compositions are optimized, and the GPT/α-CD ratios equal to or less than one half for solidification are found. The gelation time varies from 40.7 min to 5.0 h depending on the increase in GPT/α-CD ratios and aqCT amount. The aqCT extract disturbs the hydrogen bonding and host–guest inclusion of GPT/α-CD gel networks, postponing the gelation. Scanning electron microscope observation shows that all gels with or without aqCT possess a microarchitecture and porosity. GPT/α-CD/aqCT gels could release polyphenols from 110 to 350 nmol/mL at the first hour and sustainably from 5.5 to 20.2 nmol/mL for the following hours, which is controlled by feeding the aqCT amount and gel properties. GPT/α-CD/aqCT gels achieved significant antioxidant activity through a 100% scavenging DPPH radical. In addition, all gels are non-cytotoxic with a cell viability more than 85%. Especially, the GPT3.75α-CD10.5aqCT gels with aqCT amount of 3.1–12.5 mg/mL immensely enhanced the cell proliferation of GPT3.75α-CD10.5 gel without extract. These results suggest that the inherent bioactivities of aqCT endowed the resulting GPT/α-CD/aqCT gels with effective antioxidant and high biocompatibility, and natural polyphenols sustainably release a unique platform for a drug delivery system or other biomedical applications.https://www.mdpi.com/1422-0067/22/16/8759supramolecular gels<i>Cordyline terminalis</i>polyphenolsantioxidant |
| spellingShingle | Dieu Phuong Nguyen Thi Dieu Linh Tran Phuong Le Thi Ki Dong Park Thai Thanh Hoang Thi Supramolecular Gels Incorporating <i>Cordyline terminalis</i> Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications International Journal of Molecular Sciences supramolecular gels <i>Cordyline terminalis</i> polyphenols antioxidant |
| title | Supramolecular Gels Incorporating <i>Cordyline terminalis</i> Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications |
| title_full | Supramolecular Gels Incorporating <i>Cordyline terminalis</i> Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications |
| title_fullStr | Supramolecular Gels Incorporating <i>Cordyline terminalis</i> Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications |
| title_full_unstemmed | Supramolecular Gels Incorporating <i>Cordyline terminalis</i> Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications |
| title_short | Supramolecular Gels Incorporating <i>Cordyline terminalis</i> Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications |
| title_sort | supramolecular gels incorporating i cordyline terminalis i leaf extract as a polyphenol release scaffold for biomedical applications |
| topic | supramolecular gels <i>Cordyline terminalis</i> polyphenols antioxidant |
| url | https://www.mdpi.com/1422-0067/22/16/8759 |
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