Phylogenetic classification of natural product biosynthetic gene clusters based on regulatory mechanisms

Phylogenetic classification of natural product biosynthetic gene clusters based on regulatory mechanisms

The natural products (NPs) biosynthetic gene clusters (BGCs) represent the adapting biochemical toolkit for microorganisms to thrive different microenvironments. Despite their high diversity, particularly at the genomic level, detecting them in a shake-flask is challenging and remains the primary ob...

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Bibliographic Details
Main Authors: Alberto C. Rodriguez-Sanchez, Luz A. Gónzalez-Salazar, Lorena Rodriguez-Orduña, Ándres Cumsille, Agustina Undabarrena, Beatriz Camara, Nelly Sélem-Mojica, Cuauhtemoc Licona-Cassani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Microbiology
Subjects:
gene regulation
biosynthetic gene cluster
natural product
transcription factor
histidine kinase
two component system
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1290473/full

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