Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients
ObjectiveThe severity of cerebral small vessel disease (SVD) on magnetic resonance imaging (MRI) has been assessed using hypertensive arteriopathy SVD and cerebral amyloid angiopathy (CAA)-SVD scores. In addition, we reported the modified CAA-SVD score including cortical microinfarcts and posterior...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1155122/full |
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| author | Kana Matsuda Masaki Shinohara Yuichiro Ii Ken-ichi Tabei Yukito Ueda Naoko Nakamura Yoshinori Hirata Hidehiro Ishikawa Hirofumi Matsuyama Keita Matsuura Masayuki Satoh Masayuki Maeda Ryo Momosaki Hidekazu Tomimoto Akihiro Shindo Akihiro Shindo |
| author_facet | Kana Matsuda Masaki Shinohara Yuichiro Ii Ken-ichi Tabei Yukito Ueda Naoko Nakamura Yoshinori Hirata Hidehiro Ishikawa Hirofumi Matsuyama Keita Matsuura Masayuki Satoh Masayuki Maeda Ryo Momosaki Hidekazu Tomimoto Akihiro Shindo Akihiro Shindo |
| author_sort | Kana Matsuda |
| collection | DOAJ |
| description | ObjectiveThe severity of cerebral small vessel disease (SVD) on magnetic resonance imaging (MRI) has been assessed using hypertensive arteriopathy SVD and cerebral amyloid angiopathy (CAA)-SVD scores. In addition, we reported the modified CAA-SVD score including cortical microinfarcts and posterior dominant white matter hyperintensity. Each SVD score has been associated with cognitive function, but the longitudinal changes remain unclear. Therefore, this study prospectively examined the prognostic value of each SVD score, imaging findings of cerebral SVD, and neuropsychological assessment.MethodsThis study included 29 patients diagnosed with mild cognitive impairment or mild dementia at memory clinic in our hospital, who underwent clinical dementia rating (CDR) and brain MRI (3D-fluid attenuated inversion recovery, 3D-double inversion recovery, and susceptibility-weighted imaging) at baseline and 1 year later. Each SVD score and neuropsychological tests including the Mini-Mental State Examination, Japanese Raven’s Colored Progressive Matrices, Trail Making Test -A/-B, and the Rivermead Behavioral Memory Test were evaluated at baseline and 1 year later.ResultsTwenty patients had unchanged CDR (group A), while nine patients had worsened CDR (group B) after 1 year. At baseline, there was no significant difference in each SVD score; after 1 year, group B had significantly increased CAA-SVD and modified CAA-SVD scores. Group B also showed a significantly higher number of lobar microbleeds than group A at baseline. Furthermore, group B had significantly longer Japanese Raven’s Colored Progressive Matrices and Trail Making test-A times at baseline. After 1 year, group B had significantly lower Mini-Mental State Examination, Japanese Raven’s Colored Progressive Matrices, and Rivermead Behavioral Memory Test scores and significantly fewer word fluency (letters).ConclusionPatients with worsened CDR 1 year after had a higher number of lobar microbleeds and prolonged psychomotor speed at baseline. These findings may become predictors of cognitive deterioration in patients who visit memory clinics. |
| first_indexed | 2024-03-12T17:47:08Z |
| format | Article |
| id | doaj.art-fb47a5cca764440eb0693ac76a8d38ef |
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| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-12T17:47:08Z |
| publishDate | 2023-08-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-fb47a5cca764440eb0693ac76a8d38ef2023-08-03T15:00:40ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-08-011510.3389/fnagi.2023.11551221155122Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patientsKana Matsuda0Masaki Shinohara1Yuichiro Ii2Ken-ichi Tabei3Yukito Ueda4Naoko Nakamura5Yoshinori Hirata6Hidehiro Ishikawa7Hirofumi Matsuyama8Keita Matsuura9Masayuki Satoh10Masayuki Maeda11Ryo Momosaki12Hidekazu Tomimoto13Akihiro Shindo14Akihiro Shindo15Department of Dementia Prevention and Therapeutics, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neuroradiology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Rehabilitation Medicine, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Dementia Prevention and Therapeutics, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, JapanObjectiveThe severity of cerebral small vessel disease (SVD) on magnetic resonance imaging (MRI) has been assessed using hypertensive arteriopathy SVD and cerebral amyloid angiopathy (CAA)-SVD scores. In addition, we reported the modified CAA-SVD score including cortical microinfarcts and posterior dominant white matter hyperintensity. Each SVD score has been associated with cognitive function, but the longitudinal changes remain unclear. Therefore, this study prospectively examined the prognostic value of each SVD score, imaging findings of cerebral SVD, and neuropsychological assessment.MethodsThis study included 29 patients diagnosed with mild cognitive impairment or mild dementia at memory clinic in our hospital, who underwent clinical dementia rating (CDR) and brain MRI (3D-fluid attenuated inversion recovery, 3D-double inversion recovery, and susceptibility-weighted imaging) at baseline and 1 year later. Each SVD score and neuropsychological tests including the Mini-Mental State Examination, Japanese Raven’s Colored Progressive Matrices, Trail Making Test -A/-B, and the Rivermead Behavioral Memory Test were evaluated at baseline and 1 year later.ResultsTwenty patients had unchanged CDR (group A), while nine patients had worsened CDR (group B) after 1 year. At baseline, there was no significant difference in each SVD score; after 1 year, group B had significantly increased CAA-SVD and modified CAA-SVD scores. Group B also showed a significantly higher number of lobar microbleeds than group A at baseline. Furthermore, group B had significantly longer Japanese Raven’s Colored Progressive Matrices and Trail Making test-A times at baseline. After 1 year, group B had significantly lower Mini-Mental State Examination, Japanese Raven’s Colored Progressive Matrices, and Rivermead Behavioral Memory Test scores and significantly fewer word fluency (letters).ConclusionPatients with worsened CDR 1 year after had a higher number of lobar microbleeds and prolonged psychomotor speed at baseline. These findings may become predictors of cognitive deterioration in patients who visit memory clinics.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1155122/fullmild cognitive impairmentmild dementiahypertensive arteriopathy-small vessel disease scorecerebral amyloid angiopathy-small vessel disease scoremodified cerebral amyloid angiopathy-small vessel disease scorememory clinic |
| spellingShingle | Kana Matsuda Masaki Shinohara Yuichiro Ii Ken-ichi Tabei Yukito Ueda Naoko Nakamura Yoshinori Hirata Hidehiro Ishikawa Hirofumi Matsuyama Keita Matsuura Masayuki Satoh Masayuki Maeda Ryo Momosaki Hidekazu Tomimoto Akihiro Shindo Akihiro Shindo Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients Frontiers in Aging Neuroscience mild cognitive impairment mild dementia hypertensive arteriopathy-small vessel disease score cerebral amyloid angiopathy-small vessel disease score modified cerebral amyloid angiopathy-small vessel disease score memory clinic |
| title | Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients |
| title_full | Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients |
| title_fullStr | Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients |
| title_full_unstemmed | Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients |
| title_short | Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients |
| title_sort | magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients |
| topic | mild cognitive impairment mild dementia hypertensive arteriopathy-small vessel disease score cerebral amyloid angiopathy-small vessel disease score modified cerebral amyloid angiopathy-small vessel disease score memory clinic |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1155122/full |
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