Regulation of extracellular matrix In patients with Q-wave myocardial infarction after thrombolytic therapy
Aims. In order to study the levels of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, intracardiac hemodynamics, frequency of acute cardiac aneurysm development in patients with Q-wave myocardial infarction after thrombolysis, 74 patients were examined. Methods and results. All...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2014-04-01
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| Series: | Patologìâ |
| Subjects: | |
| Online Access: | http://pat.zsmu.edu.ua/article/view/25585/23052 |
| Summary: | Aims. In order to study the levels of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, intracardiac hemodynamics, frequency of acute cardiac aneurysm development in patients with Q-wave myocardial infarction after thrombolysis, 74 patients were examined.
Methods and results. All participants underwent clinical and laboratory examination, echocardiography, determination of serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1.
Conclusion. Patients, who got thrombolysis in 6 to 12 hours period, had excessive activation of the proteolysis system on the background of relative defi cit of tissue inhibitor of metalloproteinase-1, the prevalence of dilatation and restrictive diastolic dysfunction, cardiac aneurysm was detected frequently and thrombogenic potential was higher. |
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| ISSN: | 2306-8027 2310-1237 |