Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions
This study investigated thiamine degradation in thiamine mononitrate (TMN):polymer solid dispersions, accounting for the physical state of the vitamin and the recrystallization tendency of TMN in these dispersions. Results were compared with those from solid dispersions containing a different salt f...
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/24/9370 |
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| author | Seda Arioglu-Tuncil Adrienne L. Voelker Lynne S. Taylor Lisa J. Mauer |
| author_facet | Seda Arioglu-Tuncil Adrienne L. Voelker Lynne S. Taylor Lisa J. Mauer |
| author_sort | Seda Arioglu-Tuncil |
| collection | DOAJ |
| description | This study investigated thiamine degradation in thiamine mononitrate (TMN):polymer solid dispersions, accounting for the physical state of the vitamin and the recrystallization tendency of TMN in these dispersions. Results were compared with those from solid dispersions containing a different salt form of thiamine (thiamine chloride hydrochloride (TClHCl)). TMN:polymer dispersions were prepared by lyophilizing solutions containing TMN and amorphous polymers (pectin and PVP (polyvinylpyrrolidone)). Samples were stored in controlled temperature and relative humidity (RH) environments for eight weeks and monitored periodically by X-ray diffraction and high performance liquid chromatography (HPLC). Moisture sorption, glass transition temperature (T<sub>g</sub>), intermolecular interactions, and pH were also determined. Similar to the TClHCl:polymer dispersions, thiamine was more chemically labile in the amorphous state than the crystalline state, when present in lower proportions in amorphous TMN:polymer dispersions despite increasing T<sub>g</sub> values, when environmental storage conditions exceeded the T<sub>g</sub> of the dispersion, and when co-formulated with PVP compared to pectin. When thiamine remained as an amorphous solid, chemical stability of thiamine did not differ as a function of counterion present (TMN vs. TClHCl). However, storage at 75% RH led to hydration of thiamine:PVP dispersions, and the resulting pH of the solutions as a function of thiamine salt form led to a higher chemical stability in the acidic TClHCl samples than in the neutral TMN samples. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:14:10Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fb4b10a99af6468a97b5d65728c5dc572023-11-21T00:00:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124937010.3390/ijms21249370Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid DispersionsSeda Arioglu-Tuncil0Adrienne L. Voelker1Lynne S. Taylor2Lisa J. Mauer3Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USADepartment of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USADepartment of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USADepartment of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USAThis study investigated thiamine degradation in thiamine mononitrate (TMN):polymer solid dispersions, accounting for the physical state of the vitamin and the recrystallization tendency of TMN in these dispersions. Results were compared with those from solid dispersions containing a different salt form of thiamine (thiamine chloride hydrochloride (TClHCl)). TMN:polymer dispersions were prepared by lyophilizing solutions containing TMN and amorphous polymers (pectin and PVP (polyvinylpyrrolidone)). Samples were stored in controlled temperature and relative humidity (RH) environments for eight weeks and monitored periodically by X-ray diffraction and high performance liquid chromatography (HPLC). Moisture sorption, glass transition temperature (T<sub>g</sub>), intermolecular interactions, and pH were also determined. Similar to the TClHCl:polymer dispersions, thiamine was more chemically labile in the amorphous state than the crystalline state, when present in lower proportions in amorphous TMN:polymer dispersions despite increasing T<sub>g</sub> values, when environmental storage conditions exceeded the T<sub>g</sub> of the dispersion, and when co-formulated with PVP compared to pectin. When thiamine remained as an amorphous solid, chemical stability of thiamine did not differ as a function of counterion present (TMN vs. TClHCl). However, storage at 75% RH led to hydration of thiamine:PVP dispersions, and the resulting pH of the solutions as a function of thiamine salt form led to a higher chemical stability in the acidic TClHCl samples than in the neutral TMN samples.https://www.mdpi.com/1422-0067/21/24/9370vitamin B<sub>1</sub>thiaminethiamine mononitratethiamine degradationamorphous solid dispersionphysical stability |
| spellingShingle | Seda Arioglu-Tuncil Adrienne L. Voelker Lynne S. Taylor Lisa J. Mauer Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions International Journal of Molecular Sciences vitamin B<sub>1</sub> thiamine thiamine mononitrate thiamine degradation amorphous solid dispersion physical stability |
| title | Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions |
| title_full | Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions |
| title_fullStr | Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions |
| title_full_unstemmed | Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions |
| title_short | Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions |
| title_sort | amorphization of thiamine mononitrate a study of crystallization inhibition and chemical stability of thiamine in thiamine mononitrate amorphous solid dispersions |
| topic | vitamin B<sub>1</sub> thiamine thiamine mononitrate thiamine degradation amorphous solid dispersion physical stability |
| url | https://www.mdpi.com/1422-0067/21/24/9370 |
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