An observational and Mendelian randomisation study on iron status and sepsis
Abstract Iron deficiency is associated with a substantial burden of morbidity. However, supplementation of iron has been linked to increased rates of serious infection in randomised trials of children in sub-Saharan Africa. Randomised trials in other settings have been inconclusive and it is unknown...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29641-6 |
| _version_ | 1797259323250835456 |
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| author | Fergus Hamilton Ruth Mitchell Haroon Ahmed Peter Ghazal Nicholas J. Timpson |
| author_facet | Fergus Hamilton Ruth Mitchell Haroon Ahmed Peter Ghazal Nicholas J. Timpson |
| author_sort | Fergus Hamilton |
| collection | DOAJ |
| description | Abstract Iron deficiency is associated with a substantial burden of morbidity. However, supplementation of iron has been linked to increased rates of serious infection in randomised trials of children in sub-Saharan Africa. Randomised trials in other settings have been inconclusive and it is unknown if changes in levels of iron biomarkers are linked to sepsis in these other settings. We used genetic variants associated with levels of iron biomarkers as instrumental variables in a Mendelian randomisation (MR) analysis to test the hypothesis that increasing levels of iron biomarkers increase the risk of sepsis. In observational and MR analyses we found that increases in iron biomarkers increase the odds of sepsis. In stratified analyses, we show that this risk may be larger in those with iron deficiency and/or anaemia. Taken together, results here suggest a required caution in supplementation of iron and underline the role of iron homeostasis in severe infection. |
| first_indexed | 2024-04-24T23:07:36Z |
| format | Article |
| id | doaj.art-fb4bccd8ff134e8aa66500cce794d02c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T23:07:36Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fb4bccd8ff134e8aa66500cce794d02c2024-03-17T12:27:04ZengNature PortfolioScientific Reports2045-23222023-02-0113111410.1038/s41598-023-29641-6An observational and Mendelian randomisation study on iron status and sepsisFergus Hamilton0Ruth Mitchell1Haroon Ahmed2Peter Ghazal3Nicholas J. Timpson4MRC Integrative Epidemiology Unit, University of Bristol, Oakfield HouseMRC Integrative Epidemiology Unit, University of Bristol, Oakfield HouseDivision of Population Medicine, Cardiff University Medical SchoolSystem Immunity Research Institute, Division of Infection and Immunity, Cardiff UniversityMRC Integrative Epidemiology Unit, University of Bristol, Oakfield HouseAbstract Iron deficiency is associated with a substantial burden of morbidity. However, supplementation of iron has been linked to increased rates of serious infection in randomised trials of children in sub-Saharan Africa. Randomised trials in other settings have been inconclusive and it is unknown if changes in levels of iron biomarkers are linked to sepsis in these other settings. We used genetic variants associated with levels of iron biomarkers as instrumental variables in a Mendelian randomisation (MR) analysis to test the hypothesis that increasing levels of iron biomarkers increase the risk of sepsis. In observational and MR analyses we found that increases in iron biomarkers increase the odds of sepsis. In stratified analyses, we show that this risk may be larger in those with iron deficiency and/or anaemia. Taken together, results here suggest a required caution in supplementation of iron and underline the role of iron homeostasis in severe infection.https://doi.org/10.1038/s41598-023-29641-6 |
| spellingShingle | Fergus Hamilton Ruth Mitchell Haroon Ahmed Peter Ghazal Nicholas J. Timpson An observational and Mendelian randomisation study on iron status and sepsis Scientific Reports |
| title | An observational and Mendelian randomisation study on iron status and sepsis |
| title_full | An observational and Mendelian randomisation study on iron status and sepsis |
| title_fullStr | An observational and Mendelian randomisation study on iron status and sepsis |
| title_full_unstemmed | An observational and Mendelian randomisation study on iron status and sepsis |
| title_short | An observational and Mendelian randomisation study on iron status and sepsis |
| title_sort | observational and mendelian randomisation study on iron status and sepsis |
| url | https://doi.org/10.1038/s41598-023-29641-6 |
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