PASA: Proteomic analysis of serum antibodies web server.
<h4>Motivation</h4>A comprehensive characterization of the humoral response towards a specific antigen requires quantification of the B-cell receptor repertoire by next-generation sequencing (BCR-Seq), as well as the analysis of serum antibodies against this antigen, using proteomics. Th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1008607 |
| _version_ | 1819008096461127680 |
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| author | Oren Avram Aya Kigel Anna Vaisman-Mentesh Sharon Kligsberg Shai Rosenstein Yael Dror Tal Pupko Yariv Wine |
| author_facet | Oren Avram Aya Kigel Anna Vaisman-Mentesh Sharon Kligsberg Shai Rosenstein Yael Dror Tal Pupko Yariv Wine |
| author_sort | Oren Avram |
| collection | DOAJ |
| description | <h4>Motivation</h4>A comprehensive characterization of the humoral response towards a specific antigen requires quantification of the B-cell receptor repertoire by next-generation sequencing (BCR-Seq), as well as the analysis of serum antibodies against this antigen, using proteomics. The proteomic analysis is challenging since it necessitates the mapping of antigen-specific peptides to individual B-cell clones.<h4>Results</h4>The PASA web server provides a robust computational platform for the analysis and integration of data obtained from proteomics of serum antibodies. PASA maps peptides derived from antibodies raised against a specific antigen to corresponding antibody sequences. It then analyzes and integrates proteomics and BCR-Seq data, thus providing a comprehensive characterization of the humoral response. The PASA web server is freely available at https://pasa.tau.ac.il and open to all users without a login requirement. |
| first_indexed | 2024-12-21T00:35:02Z |
| format | Article |
| id | doaj.art-fb4c53ec7c9e4dfa91544c8252dd162d |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-21T00:35:02Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-fb4c53ec7c9e4dfa91544c8252dd162d2022-12-21T19:21:49ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-01-01171e100860710.1371/journal.pcbi.1008607PASA: Proteomic analysis of serum antibodies web server.Oren AvramAya KigelAnna Vaisman-MenteshSharon KligsbergShai RosensteinYael DrorTal PupkoYariv Wine<h4>Motivation</h4>A comprehensive characterization of the humoral response towards a specific antigen requires quantification of the B-cell receptor repertoire by next-generation sequencing (BCR-Seq), as well as the analysis of serum antibodies against this antigen, using proteomics. The proteomic analysis is challenging since it necessitates the mapping of antigen-specific peptides to individual B-cell clones.<h4>Results</h4>The PASA web server provides a robust computational platform for the analysis and integration of data obtained from proteomics of serum antibodies. PASA maps peptides derived from antibodies raised against a specific antigen to corresponding antibody sequences. It then analyzes and integrates proteomics and BCR-Seq data, thus providing a comprehensive characterization of the humoral response. The PASA web server is freely available at https://pasa.tau.ac.il and open to all users without a login requirement.https://doi.org/10.1371/journal.pcbi.1008607 |
| spellingShingle | Oren Avram Aya Kigel Anna Vaisman-Mentesh Sharon Kligsberg Shai Rosenstein Yael Dror Tal Pupko Yariv Wine PASA: Proteomic analysis of serum antibodies web server. PLoS Computational Biology |
| title | PASA: Proteomic analysis of serum antibodies web server. |
| title_full | PASA: Proteomic analysis of serum antibodies web server. |
| title_fullStr | PASA: Proteomic analysis of serum antibodies web server. |
| title_full_unstemmed | PASA: Proteomic analysis of serum antibodies web server. |
| title_short | PASA: Proteomic analysis of serum antibodies web server. |
| title_sort | pasa proteomic analysis of serum antibodies web server |
| url | https://doi.org/10.1371/journal.pcbi.1008607 |
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