Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination
Microglia are important for brain homeostasis and plasticity. The mechanisms underlying microglia-neuron interactions are still unclear. Here, the authors show that microglia preferentially interact with the nodes of Ranvier along axons. This interaction is modulated by neuronal activity and contrib...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25486-7 |
| _version_ | 1818840874769973248 |
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| author | R. Ronzano T. Roux M. Thetiot M. S. Aigrot L. Richard F. X. Lejeune E. Mazuir J. M. Vallat C. Lubetzki A. Desmazières |
| author_facet | R. Ronzano T. Roux M. Thetiot M. S. Aigrot L. Richard F. X. Lejeune E. Mazuir J. M. Vallat C. Lubetzki A. Desmazières |
| author_sort | R. Ronzano |
| collection | DOAJ |
| description | Microglia are important for brain homeostasis and plasticity. The mechanisms underlying microglia-neuron interactions are still unclear. Here, the authors show that microglia preferentially interact with the nodes of Ranvier along axons. This interaction is modulated by neuronal activity and contributes to remyelination in mice. |
| first_indexed | 2024-12-19T04:17:07Z |
| format | Article |
| id | doaj.art-fb4d5db5626f437294c686841cb40c71 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:17:07Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fb4d5db5626f437294c686841cb40c712022-12-21T20:36:16ZengNature PortfolioNature Communications2041-17232021-09-0112111810.1038/s41467-021-25486-7Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelinationR. Ronzano0T. Roux1M. Thetiot2M. S. Aigrot3L. Richard4F. X. Lejeune5E. Mazuir6J. M. Vallat7C. Lubetzki8A. Desmazières9Sorbonne Université, Paris Brain Institute (ICM), INSERM U1127, CNRS UMR 7225, Hopital Pitié-SalpétrièreSorbonne Université, Paris Brain Institute (ICM), INSERM U1127, CNRS UMR 7225, Hopital Pitié-SalpétrièreSorbonne Université, Paris Brain Institute (ICM), INSERM U1127, CNRS UMR 7225, Hopital Pitié-SalpétrièreSorbonne Université, Paris Brain Institute (ICM), INSERM U1127, CNRS UMR 7225, Hopital Pitié-SalpétrièreCentre de Référence National des Neuropathies Périphériques Rares et Département de Neurologie, Hopital UniversitaireSorbonne Université, Paris Brain Institute (ICM), INSERM U1127, CNRS UMR 7225, Hopital Pitié-SalpétrièreSorbonne Université, Paris Brain Institute (ICM), INSERM U1127, CNRS UMR 7225, Hopital Pitié-SalpétrièreCentre de Référence National des Neuropathies Périphériques Rares et Département de Neurologie, Hopital UniversitaireSorbonne Université, Paris Brain Institute (ICM), INSERM U1127, CNRS UMR 7225, Hopital Pitié-SalpétrièreSorbonne Université, Paris Brain Institute (ICM), INSERM U1127, CNRS UMR 7225, Hopital Pitié-SalpétrièreMicroglia are important for brain homeostasis and plasticity. The mechanisms underlying microglia-neuron interactions are still unclear. Here, the authors show that microglia preferentially interact with the nodes of Ranvier along axons. This interaction is modulated by neuronal activity and contributes to remyelination in mice.https://doi.org/10.1038/s41467-021-25486-7 |
| spellingShingle | R. Ronzano T. Roux M. Thetiot M. S. Aigrot L. Richard F. X. Lejeune E. Mazuir J. M. Vallat C. Lubetzki A. Desmazières Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination Nature Communications |
| title | Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination |
| title_full | Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination |
| title_fullStr | Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination |
| title_full_unstemmed | Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination |
| title_short | Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination |
| title_sort | microglia neuron interaction at nodes of ranvier depends on neuronal activity through potassium release and contributes to remyelination |
| url | https://doi.org/10.1038/s41467-021-25486-7 |
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