Deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy development
Neural stem cells (NSCs) hold a very significant promise as candidates for cell therapy due to their robust neuroprotective and regenerative properties. Preclinical studies using NSCs have shown enough encouraging results to perform deeper investigations into more potential clinical applications. Ne...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1332751/full |
| _version_ | 1827383269509824512 |
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| author | Klaudia Radoszkiewicz Aleksandra Bzinkowska Magdalena Chodkowska Paulina Rybkowska Monika Sypecka Ilona Zembrzuska-Kaska Anna Sarnowska |
| author_facet | Klaudia Radoszkiewicz Aleksandra Bzinkowska Magdalena Chodkowska Paulina Rybkowska Monika Sypecka Ilona Zembrzuska-Kaska Anna Sarnowska |
| author_sort | Klaudia Radoszkiewicz |
| collection | DOAJ |
| description | Neural stem cells (NSCs) hold a very significant promise as candidates for cell therapy due to their robust neuroprotective and regenerative properties. Preclinical studies using NSCs have shown enough encouraging results to perform deeper investigations into more potential clinical applications. Nevertheless, our knowledge regarding neurogenesis and its underlying mechanisms remains incomplete. To understand them better, it seems necessary to characterize all components of neural stem cell niche and discover their role in physiology and pathology. Using NSCs in vivo brings challenges including limited cell survival and still inadequate integration within host tissue. Identifying overlooked factors that might influence these outcomes becomes pivotal. In this review, we take a deeper examination of the influence of a fundamental element that is present in the brain, the cerebrospinal fluid (CSF), which still remains relatively unexplored. Its role in neurogenesis could be instrumental to help find novel therapeutic solutions for neurological disorders, eventually advancing our knowledge on central nervous system (CNS) regeneration and repair. |
| first_indexed | 2024-03-08T14:37:48Z |
| format | Article |
| id | doaj.art-fb4e22f4fe9542b7aa86a63725807f90 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-08T14:37:48Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-fb4e22f4fe9542b7aa86a63725807f902024-01-12T04:17:31ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-01-011710.3389/fnins.2023.13327511332751Deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy developmentKlaudia RadoszkiewiczAleksandra BzinkowskaMagdalena ChodkowskaPaulina RybkowskaMonika SypeckaIlona Zembrzuska-KaskaAnna SarnowskaNeural stem cells (NSCs) hold a very significant promise as candidates for cell therapy due to their robust neuroprotective and regenerative properties. Preclinical studies using NSCs have shown enough encouraging results to perform deeper investigations into more potential clinical applications. Nevertheless, our knowledge regarding neurogenesis and its underlying mechanisms remains incomplete. To understand them better, it seems necessary to characterize all components of neural stem cell niche and discover their role in physiology and pathology. Using NSCs in vivo brings challenges including limited cell survival and still inadequate integration within host tissue. Identifying overlooked factors that might influence these outcomes becomes pivotal. In this review, we take a deeper examination of the influence of a fundamental element that is present in the brain, the cerebrospinal fluid (CSF), which still remains relatively unexplored. Its role in neurogenesis could be instrumental to help find novel therapeutic solutions for neurological disorders, eventually advancing our knowledge on central nervous system (CNS) regeneration and repair.https://www.frontiersin.org/articles/10.3389/fnins.2023.1332751/fullcerebrospinal fluidartificial cerebrospinal fluidembryonic cerebrospinal fluidadult cerebrospinal fluidneural stem cellcell therapy |
| spellingShingle | Klaudia Radoszkiewicz Aleksandra Bzinkowska Magdalena Chodkowska Paulina Rybkowska Monika Sypecka Ilona Zembrzuska-Kaska Anna Sarnowska Deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy development Frontiers in Neuroscience cerebrospinal fluid artificial cerebrospinal fluid embryonic cerebrospinal fluid adult cerebrospinal fluid neural stem cell cell therapy |
| title | Deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy development |
| title_full | Deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy development |
| title_fullStr | Deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy development |
| title_full_unstemmed | Deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy development |
| title_short | Deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy development |
| title_sort | deciphering the impact of cerebrospinal fluid on stem cell fate as a new mechanism to enhance clinical therapy development |
| topic | cerebrospinal fluid artificial cerebrospinal fluid embryonic cerebrospinal fluid adult cerebrospinal fluid neural stem cell cell therapy |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1332751/full |
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