Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and Dermatoscopy
Introduction: Basal cell carcinoma (BCC) quite frequently presents as multiple tumors in individual patients. Neoplasm’s risk factors for local recurrence have a critical impact on therapeutic management. Objective: To detect risk factors for multiple BCCs (mBCC) in individual patients and to descri...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/13/3208 |
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| author | Dimitrios Sgouros Dimitrios Rigopoulos Ioannis Panayiotides Zoe Apalla Dimitrios K. Arvanitis Melpomeni Theofili Sofia Theotokoglou Anna Syrmali Konstantinos Theodoropoulos Georgia Pappa Vasileia Damaskou Alexander Stratigos Alexander Katoulis |
| author_facet | Dimitrios Sgouros Dimitrios Rigopoulos Ioannis Panayiotides Zoe Apalla Dimitrios K. Arvanitis Melpomeni Theofili Sofia Theotokoglou Anna Syrmali Konstantinos Theodoropoulos Georgia Pappa Vasileia Damaskou Alexander Stratigos Alexander Katoulis |
| author_sort | Dimitrios Sgouros |
| collection | DOAJ |
| description | Introduction: Basal cell carcinoma (BCC) quite frequently presents as multiple tumors in individual patients. Neoplasm’s risk factors for local recurrence have a critical impact on therapeutic management. Objective: To detect risk factors for multiple BCCs (mBCC) in individual patients and to describe clinical and dermatoscopic features of low- and high-risk tumors. Materials & Methods: Our study included 225 patients with 304 surgically excised primary BCCs. All patients’ medical history and demographics were recorded. Clinical and dermatoscopic images of BCCs were evaluated for predefined criteria and statistical analyses were performed. Results: Grade II-III sunburns before adulthood (OR 2.146, <i>p</i> = 0.031) and a personal history of BCC (OR 3.403, <i>p</i> < 0.001) were the major predisposing factors for mBCC. Clinically obvious white color (OR 3.168, <i>p</i> < 0.001) and dermatoscopic detection of white shiny lines (OR 2.085, <i>p</i> = 0.025) represented strongly prognostic variables of high-risk BCC. Similarly, extensive clinico-dermatoscopic ulceration (up to 9.2-fold) and nodular morphology (3.6-fold) raise the possibility for high-risk BCC. On the contrary, dermatoscopic evidence of blue-black coloration had a negative prognostic value for high-risk neoplasms (light OR 0.269, <i>p</i> < 0.001/partial OR 0.198, <i>p</i> = 0.001). Conclusions: Profiling of mBCC patients and a thorough knowledge of high-risk tumors’ clinico-dermatoscopic morphology could provide physicians with important information towards prevention of this neoplasm. |
| first_indexed | 2024-03-10T10:02:11Z |
| format | Article |
| id | doaj.art-fb4f72f3a7844dd0b40c61d401f5edb5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:02:11Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-fb4f72f3a7844dd0b40c61d401f5edb52023-11-22T01:55:04ZengMDPI AGCancers2072-66942021-06-011313320810.3390/cancers13133208Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and DermatoscopyDimitrios Sgouros0Dimitrios Rigopoulos1Ioannis Panayiotides2Zoe Apalla3Dimitrios K. Arvanitis4Melpomeni Theofili5Sofia Theotokoglou6Anna Syrmali7Konstantinos Theodoropoulos8Georgia Pappa9Vasileia Damaskou10Alexander Stratigos11Alexander Katoulis122nd Department of Dermatology-Venereology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece1st Department of Dermatology-Venereology, Andreas Sygros Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece2nd Department of Pathology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceState Clinic of Dermatology, Hospital for Skin and Venereal Diseases, 54643 Thessaloniki, Greece2nd Department of Dermatology-Venereology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Dermatology-Venereology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Dermatology-Venereology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Dermatology-Venereology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Dermatology-Venereology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Dermatology-Venereology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Pathology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece1st Department of Dermatology-Venereology, Andreas Sygros Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece2nd Department of Dermatology-Venereology, “Attikon” General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceIntroduction: Basal cell carcinoma (BCC) quite frequently presents as multiple tumors in individual patients. Neoplasm’s risk factors for local recurrence have a critical impact on therapeutic management. Objective: To detect risk factors for multiple BCCs (mBCC) in individual patients and to describe clinical and dermatoscopic features of low- and high-risk tumors. Materials & Methods: Our study included 225 patients with 304 surgically excised primary BCCs. All patients’ medical history and demographics were recorded. Clinical and dermatoscopic images of BCCs were evaluated for predefined criteria and statistical analyses were performed. Results: Grade II-III sunburns before adulthood (OR 2.146, <i>p</i> = 0.031) and a personal history of BCC (OR 3.403, <i>p</i> < 0.001) were the major predisposing factors for mBCC. Clinically obvious white color (OR 3.168, <i>p</i> < 0.001) and dermatoscopic detection of white shiny lines (OR 2.085, <i>p</i> = 0.025) represented strongly prognostic variables of high-risk BCC. Similarly, extensive clinico-dermatoscopic ulceration (up to 9.2-fold) and nodular morphology (3.6-fold) raise the possibility for high-risk BCC. On the contrary, dermatoscopic evidence of blue-black coloration had a negative prognostic value for high-risk neoplasms (light OR 0.269, <i>p</i> < 0.001/partial OR 0.198, <i>p</i> = 0.001). Conclusions: Profiling of mBCC patients and a thorough knowledge of high-risk tumors’ clinico-dermatoscopic morphology could provide physicians with important information towards prevention of this neoplasm.https://www.mdpi.com/2072-6694/13/13/3208basal cell carcinomadermatoscopyhistopathologyskin cancerdiagnosisnon-melanoma skin cancer |
| spellingShingle | Dimitrios Sgouros Dimitrios Rigopoulos Ioannis Panayiotides Zoe Apalla Dimitrios K. Arvanitis Melpomeni Theofili Sofia Theotokoglou Anna Syrmali Konstantinos Theodoropoulos Georgia Pappa Vasileia Damaskou Alexander Stratigos Alexander Katoulis Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and Dermatoscopy Cancers basal cell carcinoma dermatoscopy histopathology skin cancer diagnosis non-melanoma skin cancer |
| title | Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and Dermatoscopy |
| title_full | Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and Dermatoscopy |
| title_fullStr | Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and Dermatoscopy |
| title_full_unstemmed | Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and Dermatoscopy |
| title_short | Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and Dermatoscopy |
| title_sort | novel insights for patients with multiple basal cell carcinomas and tumors at high risk for recurrence risk factors clinical morphology and dermatoscopy |
| topic | basal cell carcinoma dermatoscopy histopathology skin cancer diagnosis non-melanoma skin cancer |
| url | https://www.mdpi.com/2072-6694/13/13/3208 |
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