Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis
Abstract Polyphenols are the main component of Phyllanthus emblica (PE). However, polyphenols are so easy to transform that it is unknown that how drying methods driven by heating affect the anti-fatigue effect of PE. This manuscript investigated the effects of five drying methods on the chemical co...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Chinese Medicine |
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| Online Access: | https://doi.org/10.1186/s13020-023-00835-4 |
| _version_ | 1797556480687210496 |
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| author | Dingkun Zhang Xuan Deng Mengqi Li Min Qiu Yifan Zhang Gefei Li Yurou Jiang Peng Tan Sanhu Fan Youde Zheng Junzhi Lin Li Han Haozhou Huang |
| author_facet | Dingkun Zhang Xuan Deng Mengqi Li Min Qiu Yifan Zhang Gefei Li Yurou Jiang Peng Tan Sanhu Fan Youde Zheng Junzhi Lin Li Han Haozhou Huang |
| author_sort | Dingkun Zhang |
| collection | DOAJ |
| description | Abstract Polyphenols are the main component of Phyllanthus emblica (PE). However, polyphenols are so easy to transform that it is unknown that how drying methods driven by heating affect the anti-fatigue effect of PE. This manuscript investigated the effects of five drying methods on the chemical composition transformation and anti-fatigue of PE, and discussed the action mechanism. The results suggested that the anti-fatigue effect of PE with hot-air-dried at 100 °C was the best, which was as 1.63 times as that with freeze-drying. Ellagic acid (EA) may be a key component of PE in anti-fatigue, and its mechanism of action may be related to regulating intestinal microbiota, protecting mitochondria, and regulating energy metabolism. This study first revealed the thermal transformation of polyphenols in PE, found the most effective strategy for enhancing the anti-fatigue function, and explores its action mechanism. |
| first_indexed | 2024-03-10T17:03:29Z |
| format | Article |
| id | doaj.art-fb4ff45f33a64654a693b25c0b33e4e8 |
| institution | Directory Open Access Journal |
| issn | 1749-8546 |
| language | English |
| last_indexed | 2024-03-10T17:03:29Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj.art-fb4ff45f33a64654a693b25c0b33e4e82023-11-20T10:55:14ZengBMCChinese Medicine1749-85462023-10-0118111510.1186/s13020-023-00835-4Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysisDingkun Zhang0Xuan Deng1Mengqi Li2Min Qiu3Yifan Zhang4Gefei Li5Yurou Jiang6Peng Tan7Sanhu Fan8Youde Zheng9Junzhi Lin10Li Han11Haozhou Huang12State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCMState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCMPharmacy Department, Sichuan Nursing Vocational CollegeState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCMState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCMState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCMState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCMState Key Laboratory of Quality Evaluation of Traditional Chinese Medicine, Sichuan Academy of Traditional Chinese MedicineSanajon Pharmaceutical GroupSanajon Pharmaceutical GroupTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese MedicineState Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCMState Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese MedicineAbstract Polyphenols are the main component of Phyllanthus emblica (PE). However, polyphenols are so easy to transform that it is unknown that how drying methods driven by heating affect the anti-fatigue effect of PE. This manuscript investigated the effects of five drying methods on the chemical composition transformation and anti-fatigue of PE, and discussed the action mechanism. The results suggested that the anti-fatigue effect of PE with hot-air-dried at 100 °C was the best, which was as 1.63 times as that with freeze-drying. Ellagic acid (EA) may be a key component of PE in anti-fatigue, and its mechanism of action may be related to regulating intestinal microbiota, protecting mitochondria, and regulating energy metabolism. This study first revealed the thermal transformation of polyphenols in PE, found the most effective strategy for enhancing the anti-fatigue function, and explores its action mechanism.https://doi.org/10.1186/s13020-023-00835-4Phyllanthus emblica L.Ellagic acidGallic acidDrying methodResisting exercise fatigue effect |
| spellingShingle | Dingkun Zhang Xuan Deng Mengqi Li Min Qiu Yifan Zhang Gefei Li Yurou Jiang Peng Tan Sanhu Fan Youde Zheng Junzhi Lin Li Han Haozhou Huang Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis Chinese Medicine Phyllanthus emblica L. Ellagic acid Gallic acid Drying method Resisting exercise fatigue effect |
| title | Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis |
| title_full | Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis |
| title_fullStr | Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis |
| title_full_unstemmed | Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis |
| title_short | Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis |
| title_sort | thermal treatment enhances the resisting exercise fatigue effect of phyllanthus emblica l novel evidence from tannin conversion in vitro metabolomics and gut microbiota community analysis |
| topic | Phyllanthus emblica L. Ellagic acid Gallic acid Drying method Resisting exercise fatigue effect |
| url | https://doi.org/10.1186/s13020-023-00835-4 |
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