The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells
Platelets have been shown to alter immune cell function but it is not clear if this includes autoimmunity. Here the authors show that phosphatase and tensin homolog (PTEN) deficient platelets promote autoimmunity in mouse models through excessive activation of TFH cells and systemic autoimmune patho...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30444-y |
| _version_ | 1811255078826278912 |
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| author | Xue Chen Yanyan Xu Qidi Chen Heng Zhang Yu Zeng Yan Geng Lei Shen Fubin Li Lei Chen Guo-Qiang Chen Chuanxin Huang Junling Liu |
| author_facet | Xue Chen Yanyan Xu Qidi Chen Heng Zhang Yu Zeng Yan Geng Lei Shen Fubin Li Lei Chen Guo-Qiang Chen Chuanxin Huang Junling Liu |
| author_sort | Xue Chen |
| collection | DOAJ |
| description | Platelets have been shown to alter immune cell function but it is not clear if this includes autoimmunity. Here the authors show that phosphatase and tensin homolog (PTEN) deficient platelets promote autoimmunity in mouse models through excessive activation of TFH cells and systemic autoimmune pathology. |
| first_indexed | 2024-04-12T17:18:21Z |
| format | Article |
| id | doaj.art-fb500a098b534fc8b139eaae82b10862 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T17:18:21Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fb500a098b534fc8b139eaae82b108622022-12-22T03:23:35ZengNature PortfolioNature Communications2041-17232022-05-0113111310.1038/s41467-022-30444-yThe phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cellsXue Chen0Yanyan Xu1Qidi Chen2Heng Zhang3Yu Zeng4Yan Geng5Lei Shen6Fubin Li7Lei Chen8Guo-Qiang Chen9Chuanxin Huang10Junling Liu11School of Life Sciences, Shanghai UniversityDepartment of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of MedicineDepartment of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of MedicineShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of MedicineShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of MedicineDepartment of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of MedicineShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of MedicineShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of MedicineShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of MedicineDepartment of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of MedicineShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of MedicineDepartment of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of MedicinePlatelets have been shown to alter immune cell function but it is not clear if this includes autoimmunity. Here the authors show that phosphatase and tensin homolog (PTEN) deficient platelets promote autoimmunity in mouse models through excessive activation of TFH cells and systemic autoimmune pathology.https://doi.org/10.1038/s41467-022-30444-y |
| spellingShingle | Xue Chen Yanyan Xu Qidi Chen Heng Zhang Yu Zeng Yan Geng Lei Shen Fubin Li Lei Chen Guo-Qiang Chen Chuanxin Huang Junling Liu The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells Nature Communications |
| title | The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells |
| title_full | The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells |
| title_fullStr | The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells |
| title_full_unstemmed | The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells |
| title_short | The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells |
| title_sort | phosphatase pten links platelets with immune regulatory functions of mouse t follicular helper cells |
| url | https://doi.org/10.1038/s41467-022-30444-y |
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