The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells
Platelets have been shown to alter immune cell function but it is not clear if this includes autoimmunity. Here the authors show that phosphatase and tensin homolog (PTEN) deficient platelets promote autoimmunity in mouse models through excessive activation of TFH cells and systemic autoimmune patho...
Main Authors: | Xue Chen, Yanyan Xu, Qidi Chen, Heng Zhang, Yu Zeng, Yan Geng, Lei Shen, Fubin Li, Lei Chen, Guo-Qiang Chen, Chuanxin Huang, Junling Liu |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-30444-y |
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