Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these α-synuclein seeds, and may represent a protective r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02126-w |
| _version_ | 1818840736679854080 |
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| author | Jason C. Sang Eric Hidari Georg Meisl Rohan T. Ranasinghe Maria Grazia Spillantini David Klenerman |
| author_facet | Jason C. Sang Eric Hidari Georg Meisl Rohan T. Ranasinghe Maria Grazia Spillantini David Klenerman |
| author_sort | Jason C. Sang |
| collection | DOAJ |
| description | Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these α-synuclein seeds, and may represent a protective response by cells to protein aggregation. |
| first_indexed | 2024-12-19T04:14:56Z |
| format | Article |
| id | doaj.art-fb50d58e8455415e95e500de6612683f |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T04:14:56Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-fb50d58e8455415e95e500de6612683f2022-12-21T20:36:20ZengNature PortfolioCommunications Biology2399-36422021-05-014111110.1038/s42003-021-02126-wSuper-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cellsJason C. Sang0Eric Hidari1Georg Meisl2Rohan T. Ranasinghe3Maria Grazia Spillantini4David Klenerman5Department of Chemistry, University of CambridgeDepartment of Chemistry, University of CambridgeDepartment of Chemistry, University of CambridgeDepartment of Chemistry, University of CambridgeDepartment of Clinical Neuroscience, University of CambridgeDepartment of Chemistry, University of CambridgeJason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these α-synuclein seeds, and may represent a protective response by cells to protein aggregation.https://doi.org/10.1038/s42003-021-02126-w |
| spellingShingle | Jason C. Sang Eric Hidari Georg Meisl Rohan T. Ranasinghe Maria Grazia Spillantini David Klenerman Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells Communications Biology |
| title | Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells |
| title_full | Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells |
| title_fullStr | Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells |
| title_full_unstemmed | Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells |
| title_short | Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells |
| title_sort | super resolution imaging reveals α synuclein seeded aggregation in sh sy5y cells |
| url | https://doi.org/10.1038/s42003-021-02126-w |
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