Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease
Peripheral arterial disease (PAD) leads to chronic vascular occlusion and results in end organ damage in critically perfused limbs. There are currently no clinical methods available to determine the muscular damage induced by chronic mal-perfusion. This monocentric prospective cross-sectional study...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Photoacoustics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597923001325 |
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| author | Anna P. Träger Josefine S. Günther Roman Raming Lars-Philip Paulus Werner Lang Alexander Meyer Julius Kempf Milenko Caranovic Yi Li Alexandra L. Wagner Lina Tan Vera Danko Regina Trollmann Joachim Woelfle Daniel Klett Markus F. Neurath Adrian P. Regensburger Markus Eckstein Wolfgang Uter Michael Uder Yvonne Herrmann Maximilian J. Waldner Ferdinand Knieling Ulrich Rother |
| author_facet | Anna P. Träger Josefine S. Günther Roman Raming Lars-Philip Paulus Werner Lang Alexander Meyer Julius Kempf Milenko Caranovic Yi Li Alexandra L. Wagner Lina Tan Vera Danko Regina Trollmann Joachim Woelfle Daniel Klett Markus F. Neurath Adrian P. Regensburger Markus Eckstein Wolfgang Uter Michael Uder Yvonne Herrmann Maximilian J. Waldner Ferdinand Knieling Ulrich Rother |
| author_sort | Anna P. Träger |
| collection | DOAJ |
| description | Peripheral arterial disease (PAD) leads to chronic vascular occlusion and results in end organ damage in critically perfused limbs. There are currently no clinical methods available to determine the muscular damage induced by chronic mal-perfusion. This monocentric prospective cross-sectional study investigated n = 193 adults, healthy to severe PAD, in order to quantify the degree of calf muscle degeneration caused by PAD using a non-invasive hybrid ultrasound and single wavelength optoacoustic imaging (US/SWL-OAI) approach. While US provides morphologic information, SWL-OAI visualizes the absorption of pulsed laser light and the resulting sound waves from molecules undergoing thermoelastic expansion. US/SWL-OAI was compared to multispectral data, clinical disease severity, angiographic findings, phantom experiments, and histological examinations from calf muscle biopsies. We were able to show that synergistic use of US/SWL-OAI is most likely to map clinical degeneration of the muscle and progressive PAD. |
| first_indexed | 2024-03-08T12:09:14Z |
| format | Article |
| id | doaj.art-fb510c5fc8a546ee9909ffe916d51dd3 |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-03-08T12:09:14Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-fb510c5fc8a546ee9909ffe916d51dd32024-01-23T04:15:37ZengElsevierPhotoacoustics2213-59792024-02-0135100579Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery diseaseAnna P. Träger0Josefine S. Günther1Roman Raming2Lars-Philip Paulus3Werner Lang4Alexander Meyer5Julius Kempf6Milenko Caranovic7Yi Li8Alexandra L. Wagner9Lina Tan10Vera Danko11Regina Trollmann12Joachim Woelfle13Daniel Klett14Markus F. Neurath15Adrian P. Regensburger16Markus Eckstein17Wolfgang Uter18Michael Uder19Yvonne Herrmann20Maximilian J. Waldner21Ferdinand Knieling22Ulrich Rother23Department of Vascular Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, Germany; Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, GermanyDepartment of Vascular Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, Germany; Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, GermanyDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), Loschgestraße 15, D-91054 Erlangen, GermanyDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), Loschgestraße 15, D-91054 Erlangen, GermanyDepartment of Vascular Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, GermanyDepartment of Vascular Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, GermanyDepartment of Vascular Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, Germany; Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, GermanyDepartment of Vascular Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, Germany; Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, GermanyDepartment of Vascular Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, Germany; Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, GermanyDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), Loschgestraße 15, D-91054 Erlangen, GermanyDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), Loschgestraße 15, D-91054 Erlangen, GermanyDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), Loschgestraße 15, D-91054 Erlangen, GermanyDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), Loschgestraße 15, D-91054 Erlangen, GermanyDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), Loschgestraße 15, D-91054 Erlangen, GermanyDepartment of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, D-91054 Erlangen, GermanyDepartment of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, D-91054 Erlangen, Germany; Deutsches Zentrum für Immuntherapie (DZI), University Hospital Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany; Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 6, D-91052 Erlangen, GermanyDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), Loschgestraße 15, D-91054 Erlangen, GermanyDepartment of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstrasse 8-10, D-91054 Erlangen, GermanyDepartment of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-Universität Erlangen-Nürrnberg (FAU), Waldstraße 6, D-91054 Erlangen, GermanyInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander, Universität Erlangen-Nürnberg (FAU), Maximiliansplatz 1, D-91054 Erlangen, GermanyDepartment of Pediatric Cardiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Loschgestraße 15, D-91054 Erlangen, GermanyDepartment of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, D-91054 Erlangen, Germany; Deutsches Zentrum für Immuntherapie (DZI), University Hospital Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany; Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 6, D-91052 Erlangen, GermanyDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), Loschgestraße 15, D-91054 Erlangen, Germany; Correspondence to: Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054 Erlangen, Germany.Department of Vascular Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 12, D-91054 Erlangen, Germany; Correspondence to: Departmenf of Vascular Surgery, University Hospital Erlangen, Krankenhausstraße 12, 91054 Erlangen, Germany.Peripheral arterial disease (PAD) leads to chronic vascular occlusion and results in end organ damage in critically perfused limbs. There are currently no clinical methods available to determine the muscular damage induced by chronic mal-perfusion. This monocentric prospective cross-sectional study investigated n = 193 adults, healthy to severe PAD, in order to quantify the degree of calf muscle degeneration caused by PAD using a non-invasive hybrid ultrasound and single wavelength optoacoustic imaging (US/SWL-OAI) approach. While US provides morphologic information, SWL-OAI visualizes the absorption of pulsed laser light and the resulting sound waves from molecules undergoing thermoelastic expansion. US/SWL-OAI was compared to multispectral data, clinical disease severity, angiographic findings, phantom experiments, and histological examinations from calf muscle biopsies. We were able to show that synergistic use of US/SWL-OAI is most likely to map clinical degeneration of the muscle and progressive PAD.http://www.sciencedirect.com/science/article/pii/S2213597923001325Peripheral artery diseasePhotoacousticsOptoacousticsMuscle imagingMuscle degeneration |
| spellingShingle | Anna P. Träger Josefine S. Günther Roman Raming Lars-Philip Paulus Werner Lang Alexander Meyer Julius Kempf Milenko Caranovic Yi Li Alexandra L. Wagner Lina Tan Vera Danko Regina Trollmann Joachim Woelfle Daniel Klett Markus F. Neurath Adrian P. Regensburger Markus Eckstein Wolfgang Uter Michael Uder Yvonne Herrmann Maximilian J. Waldner Ferdinand Knieling Ulrich Rother Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease Photoacoustics Peripheral artery disease Photoacoustics Optoacoustics Muscle imaging Muscle degeneration |
| title | Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease |
| title_full | Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease |
| title_fullStr | Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease |
| title_full_unstemmed | Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease |
| title_short | Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease |
| title_sort | hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease |
| topic | Peripheral artery disease Photoacoustics Optoacoustics Muscle imaging Muscle degeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2213597923001325 |
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