Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review
Noncommunicable diseases (NCD) and age-associated diseases (AAD) are some of the gravest health concerns worldwide, accounting for up to 70% of total deaths globally. NCD and AAD, such as diabetes, obesity, cardiovascular disease, and cancer, are associated with low-grade chronic inflammation and po...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/18/9825 |
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| author | Tiago Alexandre Conde Ioannis Zabetakis Alexandros Tsoupras Isabel Medina Margarida Costa Joana Silva Bruno Neves Pedro Domingues M. Rosário Domingues |
| author_facet | Tiago Alexandre Conde Ioannis Zabetakis Alexandros Tsoupras Isabel Medina Margarida Costa Joana Silva Bruno Neves Pedro Domingues M. Rosário Domingues |
| author_sort | Tiago Alexandre Conde |
| collection | DOAJ |
| description | Noncommunicable diseases (NCD) and age-associated diseases (AAD) are some of the gravest health concerns worldwide, accounting for up to 70% of total deaths globally. NCD and AAD, such as diabetes, obesity, cardiovascular disease, and cancer, are associated with low-grade chronic inflammation and poor dietary habits. Modulation of the inflammatory status through dietary components is a very appellative approach to fight these diseases and is supported by increasing evidence of natural and dietary components with strong anti-inflammatory activities. The consumption of bioactive lipids has a positive impact on preventing chronic inflammation and consequently NCD and AAD. Thus, new sources of bioactive lipids have been sought out. Microalgae are rich sources of bioactive lipids such as omega-6 and -3 polyunsaturated fatty acids (PUFA) and polar lipids with associated anti-inflammatory activity. PUFAs are enzymatically and non-enzymatically catalyzed to oxylipins and have a significant role in anti and pro-resolving inflammatory responses. Therefore, a large and rapidly growing body of research has been conducted in vivo and in vitro, investigating the potential anti-inflammatory activities of microalgae lipids. This review sought to summarize and critically analyze recent evidence of the anti-inflammatory potential of microalgae lipids and their possible use to prevent or mitigate chronic inflammation. |
| first_indexed | 2024-03-10T07:36:20Z |
| format | Article |
| id | doaj.art-fb5162603c0f43dfa481305f153eed66 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:36:20Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fb5162603c0f43dfa481305f153eed662023-11-22T13:28:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-012218982510.3390/ijms22189825Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical ReviewTiago Alexandre Conde0Ioannis Zabetakis1Alexandros Tsoupras2Isabel Medina3Margarida Costa4Joana Silva5Bruno Neves6Pedro Domingues7M. Rosário Domingues8CESAM-Centre for Environmental and Marine Studies, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Biological Sciences, University of Limerick, V94 T9PX Limerick, IrelandDepartment of Biological Sciences, University of Limerick, V94 T9PX Limerick, IrelandInstituto de Investigaciones Marinas-Consejo Superior de Investigaciones Científicas (IIM-CSIC), Eduardo Cabello 6, E-36208 Vigo, SpainR&D Department, Allmicroalgae Natural Products SAA, Rua 25 de Abril 1974, 2445-287 Pataias, PortugalR&D Department, Allmicroalgae Natural Products SAA, Rua 25 de Abril 1974, 2445-287 Pataias, PortugalDepartment of Medical Sciences, Institute of Biomedicine–iBiMED, University of Aveiro, 3810-193 Aveiro, PortugalMass Spectrometry Centre, LAQV REQUIMTE, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, PortugalCESAM-Centre for Environmental and Marine Studies, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, PortugalNoncommunicable diseases (NCD) and age-associated diseases (AAD) are some of the gravest health concerns worldwide, accounting for up to 70% of total deaths globally. NCD and AAD, such as diabetes, obesity, cardiovascular disease, and cancer, are associated with low-grade chronic inflammation and poor dietary habits. Modulation of the inflammatory status through dietary components is a very appellative approach to fight these diseases and is supported by increasing evidence of natural and dietary components with strong anti-inflammatory activities. The consumption of bioactive lipids has a positive impact on preventing chronic inflammation and consequently NCD and AAD. Thus, new sources of bioactive lipids have been sought out. Microalgae are rich sources of bioactive lipids such as omega-6 and -3 polyunsaturated fatty acids (PUFA) and polar lipids with associated anti-inflammatory activity. PUFAs are enzymatically and non-enzymatically catalyzed to oxylipins and have a significant role in anti and pro-resolving inflammatory responses. Therefore, a large and rapidly growing body of research has been conducted in vivo and in vitro, investigating the potential anti-inflammatory activities of microalgae lipids. This review sought to summarize and critically analyze recent evidence of the anti-inflammatory potential of microalgae lipids and their possible use to prevent or mitigate chronic inflammation.https://www.mdpi.com/1422-0067/22/18/9825microalgaelipidsglycolipidsphospholipidsinflammationanti-inflammatory |
| spellingShingle | Tiago Alexandre Conde Ioannis Zabetakis Alexandros Tsoupras Isabel Medina Margarida Costa Joana Silva Bruno Neves Pedro Domingues M. Rosário Domingues Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review International Journal of Molecular Sciences microalgae lipids glycolipids phospholipids inflammation anti-inflammatory |
| title | Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review |
| title_full | Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review |
| title_fullStr | Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review |
| title_full_unstemmed | Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review |
| title_short | Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review |
| title_sort | microalgal lipid extracts have potential to modulate the inflammatory response a critical review |
| topic | microalgae lipids glycolipids phospholipids inflammation anti-inflammatory |
| url | https://www.mdpi.com/1422-0067/22/18/9825 |
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