The discovery, structure, and function of 5-HTR1E serotonin receptor
Abstract Serotonin (5-hydroxytryptamine, 5-HT) is a unique neurotransmitter which can regulate various biological processes by activating thirteen different receptors. These serotonin receptors are divided into seven different classes based on their structure and functions. Since these receptors co-...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01195-0 |
| _version_ | 1797452076083576832 |
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| author | Vinay Kumar Sharma Y. Peng Loh |
| author_facet | Vinay Kumar Sharma Y. Peng Loh |
| author_sort | Vinay Kumar Sharma |
| collection | DOAJ |
| description | Abstract Serotonin (5-hydroxytryptamine, 5-HT) is a unique neurotransmitter which can regulate various biological processes by activating thirteen different receptors. These serotonin receptors are divided into seven different classes based on their structure and functions. Since these receptors co-express in various tissue and cell types and share the same ligand (5-HT), it has been a challenge for the researchers to define specific pathway and separate physiological role for each of these serotonin receptors. Though the evidence of operational diversity of these receptors is continuously emerging, much work remains to be done. 5-HTR1E is a member of 5-HT1 receptor family which belongs to G-protein coupled receptors (GPCRs). Even after three decades since its discovery, 5-HTR1E remains the least explored serotonin receptor. Very high similarity with another family member (5-HTR1F) and its non-existence in mice or rats makes 5-HTR1E a difficult target to study. Despite these challenges, recent findings on the role of 5-HTR1E in neuroprotection and diseases such as cancer, have excited many researchers to explore this receptor in detail. Here, we provide the first review of 5-HTR1E, since its discovery in 1989 to 2023. We highlight the structural and functional characteristics of this important serotonin receptor in detail and propose future directions in developing 5-HTR1E as a drug target. Video Abstract |
| first_indexed | 2024-03-09T15:03:32Z |
| format | Article |
| id | doaj.art-fb52049d44d842c7b323a27dc05e492d |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-09T15:03:32Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-fb52049d44d842c7b323a27dc05e492d2023-11-26T13:49:57ZengBMCCell Communication and Signaling1478-811X2023-09-0121111110.1186/s12964-023-01195-0The discovery, structure, and function of 5-HTR1E serotonin receptorVinay Kumar Sharma0Y. Peng Loh1Section On Cellular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, NICHD, NIHSection On Cellular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, NICHD, NIHAbstract Serotonin (5-hydroxytryptamine, 5-HT) is a unique neurotransmitter which can regulate various biological processes by activating thirteen different receptors. These serotonin receptors are divided into seven different classes based on their structure and functions. Since these receptors co-express in various tissue and cell types and share the same ligand (5-HT), it has been a challenge for the researchers to define specific pathway and separate physiological role for each of these serotonin receptors. Though the evidence of operational diversity of these receptors is continuously emerging, much work remains to be done. 5-HTR1E is a member of 5-HT1 receptor family which belongs to G-protein coupled receptors (GPCRs). Even after three decades since its discovery, 5-HTR1E remains the least explored serotonin receptor. Very high similarity with another family member (5-HTR1F) and its non-existence in mice or rats makes 5-HTR1E a difficult target to study. Despite these challenges, recent findings on the role of 5-HTR1E in neuroprotection and diseases such as cancer, have excited many researchers to explore this receptor in detail. Here, we provide the first review of 5-HTR1E, since its discovery in 1989 to 2023. We highlight the structural and functional characteristics of this important serotonin receptor in detail and propose future directions in developing 5-HTR1E as a drug target. Video Abstracthttps://doi.org/10.1186/s12964-023-01195-05-HTR1ESerotoninGPCRG proteinsCell signaling |
| spellingShingle | Vinay Kumar Sharma Y. Peng Loh The discovery, structure, and function of 5-HTR1E serotonin receptor Cell Communication and Signaling 5-HTR1E Serotonin GPCR G proteins Cell signaling |
| title | The discovery, structure, and function of 5-HTR1E serotonin receptor |
| title_full | The discovery, structure, and function of 5-HTR1E serotonin receptor |
| title_fullStr | The discovery, structure, and function of 5-HTR1E serotonin receptor |
| title_full_unstemmed | The discovery, structure, and function of 5-HTR1E serotonin receptor |
| title_short | The discovery, structure, and function of 5-HTR1E serotonin receptor |
| title_sort | discovery structure and function of 5 htr1e serotonin receptor |
| topic | 5-HTR1E Serotonin GPCR G proteins Cell signaling |
| url | https://doi.org/10.1186/s12964-023-01195-0 |
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