Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

Summary: The HIV-1-envelope glycoprotein (Env) is the main target of antigen design for antibody-based prophylactic vaccines. The generation of broadly neutralizing antibodies (bNAb) likely requires the appropriate presentation of stabilized trimers preventing exposure of non-neutralizing antibody (...

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Bibliographic Details
Main Authors: Yoann Aldon, Paul F. McKay, Joel Allen, Gabriel Ozorowski, Réka Felfödiné Lévai, Monica Tolazzi, Paul Rogers, Linling He, Natalia de Val, Katalin Fábián, Gabriella Scarlatti, Jiang Zhu, Andrew B. Ward, Max Crispin, Robin J. Shattock
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718313378

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