Injectable Antiretroviral Drugs: Back to the Future
Current HIV treatment regimens provide sustained virologic suppression, at least partially restore the immune system and have limited side effects; however, they do not allow viral eradication and they are burdened by daily pill intake with a life-long commitment for the people living with HIV (PHIV...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/2/228 |
| _version_ | 1827604492170821632 |
|---|---|
| author | Marco Berruti Niccolò Riccardi Diana Canetti Sergio Lo Caputo Lucia Taramasso Antonio Di Biagio |
| author_facet | Marco Berruti Niccolò Riccardi Diana Canetti Sergio Lo Caputo Lucia Taramasso Antonio Di Biagio |
| author_sort | Marco Berruti |
| collection | DOAJ |
| description | Current HIV treatment regimens provide sustained virologic suppression, at least partially restore the immune system and have limited side effects; however, they do not allow viral eradication and they are burdened by daily pill intake with a life-long commitment for the people living with HIV (PHIV). Injectable agents might represent a turning point in the care of PHIV, allowing less frequent administration of antiretroviral treatment (ART), more widespread use of pre-exposure prophylaxis (PrEP) and more stable drug levels in the blood, thus increasing the odds to get closer to end the HIV pandemic. The aim of this manuscript is to give a comprehensive review of injectable antiretrovirals that have been used in the past, which are available now, will be available in the future, and their role in the treatment of HIV infection |
| first_indexed | 2024-03-09T06:00:47Z |
| format | Article |
| id | doaj.art-fb526c3d4f664d1dbc873c93e038ab92 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T06:00:47Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-fb526c3d4f664d1dbc873c93e038ab922023-12-03T12:09:51ZengMDPI AGViruses1999-49152021-02-0113222810.3390/v13020228Injectable Antiretroviral Drugs: Back to the FutureMarco Berruti0Niccolò Riccardi1Diana Canetti2Sergio Lo Caputo3Lucia Taramasso4Antonio Di Biagio5Infectious Diseases Unit, Department of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, ItalyDepartment of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, ItalyClinic of Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20097 Milan, ItalyClinic of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyInfectious Diseases Unit, Department of Internal Medicine, Ospedale Policlinico San Martino IRCCS, 16132 Genoa, ItalyInfectious Diseases Unit, Department of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, ItalyCurrent HIV treatment regimens provide sustained virologic suppression, at least partially restore the immune system and have limited side effects; however, they do not allow viral eradication and they are burdened by daily pill intake with a life-long commitment for the people living with HIV (PHIV). Injectable agents might represent a turning point in the care of PHIV, allowing less frequent administration of antiretroviral treatment (ART), more widespread use of pre-exposure prophylaxis (PrEP) and more stable drug levels in the blood, thus increasing the odds to get closer to end the HIV pandemic. The aim of this manuscript is to give a comprehensive review of injectable antiretrovirals that have been used in the past, which are available now, will be available in the future, and their role in the treatment of HIV infectionhttps://www.mdpi.com/1999-4915/13/2/228ARTinjectableHIVantiretroviraltreatmentPrEP |
| spellingShingle | Marco Berruti Niccolò Riccardi Diana Canetti Sergio Lo Caputo Lucia Taramasso Antonio Di Biagio Injectable Antiretroviral Drugs: Back to the Future Viruses ART injectable HIV antiretroviral treatment PrEP |
| title | Injectable Antiretroviral Drugs: Back to the Future |
| title_full | Injectable Antiretroviral Drugs: Back to the Future |
| title_fullStr | Injectable Antiretroviral Drugs: Back to the Future |
| title_full_unstemmed | Injectable Antiretroviral Drugs: Back to the Future |
| title_short | Injectable Antiretroviral Drugs: Back to the Future |
| title_sort | injectable antiretroviral drugs back to the future |
| topic | ART injectable HIV antiretroviral treatment PrEP |
| url | https://www.mdpi.com/1999-4915/13/2/228 |
| work_keys_str_mv | AT marcoberruti injectableantiretroviraldrugsbacktothefuture AT niccoloriccardi injectableantiretroviraldrugsbacktothefuture AT dianacanetti injectableantiretroviraldrugsbacktothefuture AT sergiolocaputo injectableantiretroviraldrugsbacktothefuture AT luciataramasso injectableantiretroviraldrugsbacktothefuture AT antoniodibiagio injectableantiretroviraldrugsbacktothefuture |