Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways
In this study, we investigated the effect and mechanism of Undariopsis peterseniana, an edible brown alga, on hair growth. The treatment of vibrissa follicles with U. peterseniana extract ex vivo for 21 days significantly increased the hair-fiber lengths. The U. peterseniana extract also significant...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/15/5/130 |
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| author | Jung-Il Kang Min-Kyoung Kim Ji-Hyeok Lee You-Jin Jeon Eun-Kyoung Hwang Young-Sang Koh Jin-Won Hyun Soon-Young Kwon Eun-Sook Yoo Hee-Kyoung Kang |
| author_facet | Jung-Il Kang Min-Kyoung Kim Ji-Hyeok Lee You-Jin Jeon Eun-Kyoung Hwang Young-Sang Koh Jin-Won Hyun Soon-Young Kwon Eun-Sook Yoo Hee-Kyoung Kang |
| author_sort | Jung-Il Kang |
| collection | DOAJ |
| description | In this study, we investigated the effect and mechanism of Undariopsis peterseniana, an edible brown alga, on hair growth. The treatment of vibrissa follicles with U. peterseniana extract ex vivo for 21 days significantly increased the hair-fiber lengths. The U. peterseniana extract also significantly accelerated anagen initiation in vivo. Moreover, we found that U. peterseniana extract was able to open the KATP channel, which may contribute to increased hair growth. The U. peterseniana extract decreased 5α-reductase activity and markedly increased the proliferation of dermal papilla cells, a central regulator of the hair cycle. The U. peterseniana extract increased the levels of cell cycle proteins, such as Cyclin D1, phospho(ser780)-pRB, Cyclin E, phospho-CDK2, and CDK2. The U. peterseniana extract also increased the phosphorylation of ERK and the levels of Wnt/β-catenin signaling proteins such as glycogen synthase kinase-3β (GSK-3β) and β-catenin. These results suggested that the U. peterseniana extract had the potential to influence hair growth by dermal papilla cells proliferation through the activation of the Wnt/β-catenin and ERK pathways. We isolated a principal of the U. peterseniana extract, which was subsequently identified as apo-9′-fucoxanthinone, a trichogenic compound. The results suggested that U. peterseniana extract may have a pivotal role in the treatment of alopecia. |
| first_indexed | 2024-04-11T13:16:33Z |
| format | Article |
| id | doaj.art-fb53a047ea474c5bbf990c0863cfc2cc |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:16:33Z |
| publishDate | 2017-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-fb53a047ea474c5bbf990c0863cfc2cc2022-12-22T04:22:23ZengMDPI AGMarine Drugs1660-33972017-05-0115513010.3390/md15050130md15050130Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK PathwaysJung-Il Kang0Min-Kyoung Kim1Ji-Hyeok Lee2You-Jin Jeon3Eun-Kyoung Hwang4Young-Sang Koh5Jin-Won Hyun6Soon-Young Kwon7Eun-Sook Yoo8Hee-Kyoung Kang9Department of Medicine, School of Medicine, Jeju National University, 102 Jejudaehakno, Jeju 63243, KoreaDepartment of Medicine, School of Medicine, Jeju National University, 102 Jejudaehakno, Jeju 63243, KoreaDepartment of Marine Life Science, Jeju National University, 102 Jejudaehakno, Jeju 63243, KoreaDepartment of Marine Life Science, Jeju National University, 102 Jejudaehakno, Jeju 63243, KoreaSeaweed Research Center, National Institute of Fisheries Science, 130 Tongilro, Mokpo 58746, KoreaDepartment of Medicine, School of Medicine, Jeju National University, 102 Jejudaehakno, Jeju 63243, KoreaDepartment of Medicine, School of Medicine, Jeju National University, 102 Jejudaehakno, Jeju 63243, KoreaDepartment of Medicine, School of Medicine, Jeju National University, 102 Jejudaehakno, Jeju 63243, KoreaDepartment of Medicine, School of Medicine, Jeju National University, 102 Jejudaehakno, Jeju 63243, KoreaDepartment of Medicine, School of Medicine, Jeju National University, 102 Jejudaehakno, Jeju 63243, KoreaIn this study, we investigated the effect and mechanism of Undariopsis peterseniana, an edible brown alga, on hair growth. The treatment of vibrissa follicles with U. peterseniana extract ex vivo for 21 days significantly increased the hair-fiber lengths. The U. peterseniana extract also significantly accelerated anagen initiation in vivo. Moreover, we found that U. peterseniana extract was able to open the KATP channel, which may contribute to increased hair growth. The U. peterseniana extract decreased 5α-reductase activity and markedly increased the proliferation of dermal papilla cells, a central regulator of the hair cycle. The U. peterseniana extract increased the levels of cell cycle proteins, such as Cyclin D1, phospho(ser780)-pRB, Cyclin E, phospho-CDK2, and CDK2. The U. peterseniana extract also increased the phosphorylation of ERK and the levels of Wnt/β-catenin signaling proteins such as glycogen synthase kinase-3β (GSK-3β) and β-catenin. These results suggested that the U. peterseniana extract had the potential to influence hair growth by dermal papilla cells proliferation through the activation of the Wnt/β-catenin and ERK pathways. We isolated a principal of the U. peterseniana extract, which was subsequently identified as apo-9′-fucoxanthinone, a trichogenic compound. The results suggested that U. peterseniana extract may have a pivotal role in the treatment of alopecia.http://www.mdpi.com/1660-3397/15/5/130Undariopsis petersenianahair growthKATP channel5α-reductasedermal papilla cellWnt/β-cateninapo-9′-fucoxanthinone |
| spellingShingle | Jung-Il Kang Min-Kyoung Kim Ji-Hyeok Lee You-Jin Jeon Eun-Kyoung Hwang Young-Sang Koh Jin-Won Hyun Soon-Young Kwon Eun-Sook Yoo Hee-Kyoung Kang Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways Marine Drugs Undariopsis peterseniana hair growth KATP channel 5α-reductase dermal papilla cell Wnt/β-catenin apo-9′-fucoxanthinone |
| title | Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways |
| title_full | Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways |
| title_fullStr | Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways |
| title_full_unstemmed | Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways |
| title_short | Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways |
| title_sort | undariopsis peterseniana promotes hair growth by the activation of wnt β catenin and erk pathways |
| topic | Undariopsis peterseniana hair growth KATP channel 5α-reductase dermal papilla cell Wnt/β-catenin apo-9′-fucoxanthinone |
| url | http://www.mdpi.com/1660-3397/15/5/130 |
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