OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma
Degenerative changes in the retina of primary open-angle glaucoma (POAG) patients are developing as response to ischemia and chronic hypoxia accompanied by intolerant IOP. For this reason, the analysis of ocular blood flow changes in glaucoma monitoring, as well as the basic tests, should be conside...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2019-08-01
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| Series: | Российский офтальмологический журнал |
| Subjects: | |
| Online Access: | https://roj.igb.ru/jour/article/view/301 |
| _version_ | 1826569967088173056 |
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| author | T. N. Yurieva S. I. Zhukova |
| author_facet | T. N. Yurieva S. I. Zhukova |
| author_sort | T. N. Yurieva |
| collection | DOAJ |
| description | Degenerative changes in the retina of primary open-angle glaucoma (POAG) patients are developing as response to ischemia and chronic hypoxia accompanied by intolerant IOP. For this reason, the analysis of ocular blood flow changes in glaucoma monitoring, as well as the basic tests, should be considered an integral part of comprehensive examination of such patients.The purpose is to identify the most informative markers of the disease and to assess the effectiveness of its antihypertensive therapy by the fixed combination Dorzolamide / Timolol (Dorzopt Plus). Material and methods. 34 patients aged 68.44 ± 4.26 years with an advanced POAG stage and sub- or decompensated IOP were examined. The examination included optical coherence tomography in the angiography mode.Results. A stable average reduction in IOP by 35.1 % (by 8.6 ± 0.7 mm Hg, p < 0.05) as compared with the baseline was achieved. IOP normalization was accompanied by a stable increase in corneal hysteresis and perfusion pressure, a decrease in the average depth of the perimetric defect, and changes in chorioretinal blood flow.Conclusion. Changes in the choroid thickness and capillary density of the retinal peripapillary layer may be considered as the most informative biomarkers in the diagnosis of glaucoma and the evaluation of antihypertensive therapy effectiveness. |
| first_indexed | 2024-04-10T02:32:05Z |
| format | Article |
| id | doaj.art-fb5872e11edb410d9620e33f962daaf7 |
| institution | Directory Open Access Journal |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| last_indexed | 2025-03-14T11:47:44Z |
| publishDate | 2019-08-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj.art-fb5872e11edb410d9620e33f962daaf72025-03-02T09:51:26ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602019-08-01123434910.21516/2072-0076-2019-12-3-43-49235OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucomaT. N. Yurieva0S. I. Zhukova1Irkutsk State Medical Academy – branch of Russian Medical Academy of Continuous EducationIrkutsk Branch of S. Fyodorov Eye Microsurgery Federal State InstitutionDegenerative changes in the retina of primary open-angle glaucoma (POAG) patients are developing as response to ischemia and chronic hypoxia accompanied by intolerant IOP. For this reason, the analysis of ocular blood flow changes in glaucoma monitoring, as well as the basic tests, should be considered an integral part of comprehensive examination of such patients.The purpose is to identify the most informative markers of the disease and to assess the effectiveness of its antihypertensive therapy by the fixed combination Dorzolamide / Timolol (Dorzopt Plus). Material and methods. 34 patients aged 68.44 ± 4.26 years with an advanced POAG stage and sub- or decompensated IOP were examined. The examination included optical coherence tomography in the angiography mode.Results. A stable average reduction in IOP by 35.1 % (by 8.6 ± 0.7 mm Hg, p < 0.05) as compared with the baseline was achieved. IOP normalization was accompanied by a stable increase in corneal hysteresis and perfusion pressure, a decrease in the average depth of the perimetric defect, and changes in chorioretinal blood flow.Conclusion. Changes in the choroid thickness and capillary density of the retinal peripapillary layer may be considered as the most informative biomarkers in the diagnosis of glaucoma and the evaluation of antihypertensive therapy effectiveness.https://roj.igb.ru/jour/article/view/301primary open-angle glaucomaoct angiographyretinal blood flowradial peripapillary plexus |
| spellingShingle | T. N. Yurieva S. I. Zhukova OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma Российский офтальмологический журнал primary open-angle glaucoma oct angiography retinal blood flow radial peripapillary plexus |
| title | OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma |
| title_full | OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma |
| title_fullStr | OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma |
| title_full_unstemmed | OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma |
| title_short | OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma |
| title_sort | oct angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open angle glaucoma |
| topic | primary open-angle glaucoma oct angiography retinal blood flow radial peripapillary plexus |
| url | https://roj.igb.ru/jour/article/view/301 |
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