Aberrant DNA Polymerase Beta Enhances <i>H. pylori</i> Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice

Aberrant DNA Polymerase Beta Enhances <i>H. pylori</i> Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice

<i>H. pylori</i> is a significant risk factor of gastric cancer that induces chronic inflammation and oxidative DNA damage to promote gastric carcinoma. Base excision repair (BER) is required to maintain the genome integrity and prevent oxidative DNA damage. Mutation in DNA polymerase be...

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Bibliographic Details
Main Authors: Shengyuan Zhao, Megha Thakur, Alex W. Klattenhoff, Dawit Kidane
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
mutation in DNA polymerase beta
genomic instability
<i>H. pylori</i>
gastric cancer
Online Access:https://www.mdpi.com/2072-6694/11/6/843

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