The Association between Parkinson’s Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study
The purpose of this nationwide longitudinal follow-up study is to investigate the relationship between Parkinson’s disease (PD) and congestive heart failure (CHF) patients in Korea. Patient data were collected using the National Health Insurance Service (NHIS) Health Screening (HEALS) cohort. The In...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/9/1357 |
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| author | Jimin Kim Hakyung Kim Sol Bi Kim Woo Yup Kim Seung Hun Sheen Inbo Han Je Beom Hong Seil Sohn |
| author_facet | Jimin Kim Hakyung Kim Sol Bi Kim Woo Yup Kim Seung Hun Sheen Inbo Han Je Beom Hong Seil Sohn |
| author_sort | Jimin Kim |
| collection | DOAJ |
| description | The purpose of this nationwide longitudinal follow-up study is to investigate the relationship between Parkinson’s disease (PD) and congestive heart failure (CHF) patients in Korea. Patient data were collected using the National Health Insurance Service (NHIS) Health Screening (HEALS) cohort. The International Classification of Diseases 10-CM code G-20 distinguished 6475 PD patients who were enrolled in the PD group. After removing 1039 patients who were not hospitalized or attended an outpatient clinic less than twice, the total number of participants was reduced to 5436 individuals. Then, 177 patients diagnosed before 1 January 2004 were removed for relevancy, leaving us with 5259 PD patients. After case–control matching was completed using 1:5 age- and gender-coordinated matching, 26,295 people were chosen as part of the control group. The Cox proportional hazards regression analysis and the Kaplan–Meier technique were used to assess the risk of CHF in patients with Parkinson’s disease. After controlling for age and gender, the hazard ratio of CHF in the PD group was 5.607 (95% confidence interval (CI), 4.496–6.993). After that, the hazard ratio of CHF in the PD group was modified against for comorbid medical disorders, resulting in a value of 5.696 (95% CI, 4.566–7.107). In subgroup analysis, CHF incidence rates were significantly increased in the PD group compared to the control group (males and females; aged ≥ 65 and <65; the non-diabetes and diabetes, hypertension and non-hypertension, and dyslipidemia and non-dyslipidemia subgroups). This nationwide longitudinal study shows a higher incidence rate of CHF in PD patients. |
| first_indexed | 2024-03-10T22:34:44Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T22:34:44Z |
| publishDate | 2023-09-01 |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-fb5a6721d3dc423aadb97603226324c52023-11-19T11:31:05ZengMDPI AGJournal of Personalized Medicine2075-44262023-09-01139135710.3390/jpm13091357The Association between Parkinson’s Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort StudyJimin Kim0Hakyung Kim1Sol Bi Kim2Woo Yup Kim3Seung Hun Sheen4Inbo Han5Je Beom Hong6Seil Sohn7Cornell University, Ithaca, NY 14850, USAGenome & Health Big Data Branch, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Neurosurgery, CHA University College of Medicine, 59, Yatap-ro, Bundang-gu, Seongnam-si 13496, Republic of KoreaDepartment of Neurosurgery, CHA University College of Medicine, 59, Yatap-ro, Bundang-gu, Seongnam-si 13496, Republic of KoreaDepartment of Neurosurgery, CHA University College of Medicine, 59, Yatap-ro, Bundang-gu, Seongnam-si 13496, Republic of KoreaDepartment of Neurosurgery, CHA University College of Medicine, 59, Yatap-ro, Bundang-gu, Seongnam-si 13496, Republic of KoreaDepartment of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of KoreaDepartment of Neurosurgery, CHA University College of Medicine, 59, Yatap-ro, Bundang-gu, Seongnam-si 13496, Republic of KoreaThe purpose of this nationwide longitudinal follow-up study is to investigate the relationship between Parkinson’s disease (PD) and congestive heart failure (CHF) patients in Korea. Patient data were collected using the National Health Insurance Service (NHIS) Health Screening (HEALS) cohort. The International Classification of Diseases 10-CM code G-20 distinguished 6475 PD patients who were enrolled in the PD group. After removing 1039 patients who were not hospitalized or attended an outpatient clinic less than twice, the total number of participants was reduced to 5436 individuals. Then, 177 patients diagnosed before 1 January 2004 were removed for relevancy, leaving us with 5259 PD patients. After case–control matching was completed using 1:5 age- and gender-coordinated matching, 26,295 people were chosen as part of the control group. The Cox proportional hazards regression analysis and the Kaplan–Meier technique were used to assess the risk of CHF in patients with Parkinson’s disease. After controlling for age and gender, the hazard ratio of CHF in the PD group was 5.607 (95% confidence interval (CI), 4.496–6.993). After that, the hazard ratio of CHF in the PD group was modified against for comorbid medical disorders, resulting in a value of 5.696 (95% CI, 4.566–7.107). In subgroup analysis, CHF incidence rates were significantly increased in the PD group compared to the control group (males and females; aged ≥ 65 and <65; the non-diabetes and diabetes, hypertension and non-hypertension, and dyslipidemia and non-dyslipidemia subgroups). This nationwide longitudinal study shows a higher incidence rate of CHF in PD patients.https://www.mdpi.com/2075-4426/13/9/1357Parkinson’s diseasepopulationcongestive heart failureepidemiology |
| spellingShingle | Jimin Kim Hakyung Kim Sol Bi Kim Woo Yup Kim Seung Hun Sheen Inbo Han Je Beom Hong Seil Sohn The Association between Parkinson’s Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study Journal of Personalized Medicine Parkinson’s disease population congestive heart failure epidemiology |
| title | The Association between Parkinson’s Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study |
| title_full | The Association between Parkinson’s Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study |
| title_fullStr | The Association between Parkinson’s Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study |
| title_full_unstemmed | The Association between Parkinson’s Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study |
| title_short | The Association between Parkinson’s Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study |
| title_sort | association between parkinson s disease and congestive heart failure in korea a nationwide longitudinal cohort study |
| topic | Parkinson’s disease population congestive heart failure epidemiology |
| url | https://www.mdpi.com/2075-4426/13/9/1357 |
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