Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy
Acute neurologic complications from Varicella-Zoster-Virus reactivation occur in both immunocompromised and immunocompetent patients. In this report, we describe a case of a previously healthy immunocompetent boy who had received two doses of varicella vaccine at 1 and 4 years. At the age of 12 he d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/2/309 |
| _version_ | 1797617961907781632 |
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| author | Sibylle Bierbaum Veronika Fischer Lutz Briedigkeit Claudius Werner Hartmut Hengel Daniela Huzly |
| author_facet | Sibylle Bierbaum Veronika Fischer Lutz Briedigkeit Claudius Werner Hartmut Hengel Daniela Huzly |
| author_sort | Sibylle Bierbaum |
| collection | DOAJ |
| description | Acute neurologic complications from Varicella-Zoster-Virus reactivation occur in both immunocompromised and immunocompetent patients. In this report, we describe a case of a previously healthy immunocompetent boy who had received two doses of varicella vaccine at 1 and 4 years. At the age of 12 he developed acute aseptic meningitis caused by vaccine-type varicella-zoster-virus without concomitant skin eruptions. VZV-vaccine strain DNA was detected in the cerebrospinal fluid. The patient made a full recovery after receiving intravenous acyclovir therapy. This disease course documents another case of a VZV vaccine-associated meningitis without development of a rash, i.e., a form of VZV infection manifesting as “zoster sine herpete”. |
| first_indexed | 2024-03-11T08:02:26Z |
| format | Article |
| id | doaj.art-fb5b5c191b554b38942f20f6f87d56d4 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T08:02:26Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-fb5b5c191b554b38942f20f6f87d56d42023-11-16T23:42:37ZengMDPI AGVaccines2076-393X2023-01-0111230910.3390/vaccines11020309Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent BoySibylle Bierbaum0Veronika Fischer1Lutz Briedigkeit2Claudius Werner3Hartmut Hengel4Daniela Huzly5Center for Microbiology and Hygiene, Institute for Virology, Medical Center, University of Freiburg, 79104 Freiburg, GermanyHelios Kliniken Schwerin, 19055 Schwerin, GermanyHelios Kliniken Schwerin, 19055 Schwerin, GermanyHelios Kliniken Schwerin, 19055 Schwerin, GermanyCenter for Microbiology and Hygiene, Institute for Virology, Medical Center, University of Freiburg, 79104 Freiburg, GermanyCenter for Microbiology and Hygiene, Institute for Virology, Medical Center, University of Freiburg, 79104 Freiburg, GermanyAcute neurologic complications from Varicella-Zoster-Virus reactivation occur in both immunocompromised and immunocompetent patients. In this report, we describe a case of a previously healthy immunocompetent boy who had received two doses of varicella vaccine at 1 and 4 years. At the age of 12 he developed acute aseptic meningitis caused by vaccine-type varicella-zoster-virus without concomitant skin eruptions. VZV-vaccine strain DNA was detected in the cerebrospinal fluid. The patient made a full recovery after receiving intravenous acyclovir therapy. This disease course documents another case of a VZV vaccine-associated meningitis without development of a rash, i.e., a form of VZV infection manifesting as “zoster sine herpete”.https://www.mdpi.com/2076-393X/11/2/309varicella zoster virusvaricella vaccinezoster sine herpete |
| spellingShingle | Sibylle Bierbaum Veronika Fischer Lutz Briedigkeit Claudius Werner Hartmut Hengel Daniela Huzly Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy Vaccines varicella zoster virus varicella vaccine zoster sine herpete |
| title | Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy |
| title_full | Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy |
| title_fullStr | Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy |
| title_full_unstemmed | Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy |
| title_short | Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy |
| title_sort | meningitis without rash after reactivation of varicella vaccine strain in a 12 year old immunocompetent boy |
| topic | varicella zoster virus varicella vaccine zoster sine herpete |
| url | https://www.mdpi.com/2076-393X/11/2/309 |
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