Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study
The aim of this study was to evaluate the impact of non-surgical periodontal treatment (NS-PT) on periodontal parameters and inflammatory biomarkers in the concentration and level of calprotectin (CLP) in women with periodontitis and rheumatoid arthritis (RA). In this quasi-experimental study, we ev...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Diseases |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9721/12/1/12 |
| _version_ | 1797344323523575808 |
|---|---|
| author | Elena Aurora Popoca-Hernández Rita Elizabeth Martínez-Martínez Roberto Fidencio González-Amaro Perla del Carmen Niño-Moreno José Luis Ayala-Herrera Alberto Vinicio Jerezano-Domínguez Leon Francisco Espinosa-Cristóbal María de Lourdes Márquez-Corona Irene Aurora Espinosa-de Santillana Carlo Eduardo Medina-Solís |
| author_facet | Elena Aurora Popoca-Hernández Rita Elizabeth Martínez-Martínez Roberto Fidencio González-Amaro Perla del Carmen Niño-Moreno José Luis Ayala-Herrera Alberto Vinicio Jerezano-Domínguez Leon Francisco Espinosa-Cristóbal María de Lourdes Márquez-Corona Irene Aurora Espinosa-de Santillana Carlo Eduardo Medina-Solís |
| author_sort | Elena Aurora Popoca-Hernández |
| collection | DOAJ |
| description | The aim of this study was to evaluate the impact of non-surgical periodontal treatment (NS-PT) on periodontal parameters and inflammatory biomarkers in the concentration and level of calprotectin (CLP) in women with periodontitis and rheumatoid arthritis (RA). In this quasi-experimental study, we evaluated 30 women (mean age: 52.0 ± 5.8 years) with periodontitis and RA who had been diagnosed and treated for RA for more than 3 years and whose activity markers remained at similar values without significant reduction over three consecutive months. Patients underwent NS-PT, which included plaque control, scaling, and root planing. Serum and saliva samples, periodontal indices, RA activity markers, Disease Activity Score-28 (DAS28), the erythrocyte sedimentation rate (ESR), and the C-reactive protein (CRP) and CLP contents were measured at the beginning of the study and 6 and 12 weeks after NS-PT. Parametric and nonparametric tests were used in the analysis. The mean age was 52.0 ± 5.8 years. Compared to the baseline results, all periodontal indices were significantly reduced 6 and 12 weeks after NS-PT (<i>p</i> < 0.001). DAS28 was also significantly reduced after 12 weeks (<i>p</i> < 0.0001). Similarly, the serum CLP concentration decreased 6 and 12 weeks after NS-PT (<i>p</i> < 0.0001). Of the patients, 100% presented lower levels of CRP and ESR (<i>p</i> < 0.0001). Overall, NS-PT reduced inflammation and disease activity, highlighting the importance of oral health in the control and treatment of systemic diseases such as RA and confirming that NS-PT effectively reduces periodontitis activity and plays a key role in modulating RA activity. Therefore, NS-PT should be considered as an adjunct treatment for RA. |
| first_indexed | 2024-03-08T11:00:43Z |
| format | Article |
| id | doaj.art-fb5c0f53091f4e1e83d72703a8fc61b9 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-08T11:00:43Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-fb5c0f53091f4e1e83d72703a8fc61b92024-01-26T16:03:22ZengMDPI AGDiseases2079-97212024-01-011211210.3390/diseases12010012Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental StudyElena Aurora Popoca-Hernández0Rita Elizabeth Martínez-Martínez1Roberto Fidencio González-Amaro2Perla del Carmen Niño-Moreno3José Luis Ayala-Herrera4Alberto Vinicio Jerezano-Domínguez5Leon Francisco Espinosa-Cristóbal6María de Lourdes Márquez-Corona7Irene Aurora Espinosa-de Santillana8Carlo Eduardo Medina-Solís9Doctoral Program in Basic Biomedical Sciences, Faculty of Medicine, Autonomous University of San Luis Potosi, San Luis Potosi 78210, MexicoMaster Program in Advanced Dentistry, Faculty of Dentistry, Autonomous University of San Luis Potosi, San Luis Potosi 78290, MexicoDepartment of Immunology, Faculty of Medicine, Autonomous University of San Luis Potosi, San Luis Potosi 78210, MexicoCenter of Research in Health Sciences and Biomedicine, Faculty of Medicine, Autonomous University of San Luis Potosi, San Luis Potosi 78210, MexicoSchool of Dentistry, Universidad De La Salle Bajío, Leon 37150, MexicoSchool of Stomatology, Meritorious Autonomous University of Puebla, Puebla 72410, MexicoMaster Program in Dental Sciences, Stomatology Department, Institute of Biomedical Sciences, Autonomous University of Juarez City, Ciudad Juárez 32310, MexicoAcademic Area of Dentistry, Health Sciences Institute, Autonomous University of Hidalgo State, Pachuca 42160, MexicoSchool of Stomatology, Meritorious Autonomous University of Puebla, Puebla 72410, MexicoAcademic Area of Dentistry, Health Sciences Institute, Autonomous University of Hidalgo State, Pachuca 42160, MexicoThe aim of this study was to evaluate the impact of non-surgical periodontal treatment (NS-PT) on periodontal parameters and inflammatory biomarkers in the concentration and level of calprotectin (CLP) in women with periodontitis and rheumatoid arthritis (RA). In this quasi-experimental study, we evaluated 30 women (mean age: 52.0 ± 5.8 years) with periodontitis and RA who had been diagnosed and treated for RA for more than 3 years and whose activity markers remained at similar values without significant reduction over three consecutive months. Patients underwent NS-PT, which included plaque control, scaling, and root planing. Serum and saliva samples, periodontal indices, RA activity markers, Disease Activity Score-28 (DAS28), the erythrocyte sedimentation rate (ESR), and the C-reactive protein (CRP) and CLP contents were measured at the beginning of the study and 6 and 12 weeks after NS-PT. Parametric and nonparametric tests were used in the analysis. The mean age was 52.0 ± 5.8 years. Compared to the baseline results, all periodontal indices were significantly reduced 6 and 12 weeks after NS-PT (<i>p</i> < 0.001). DAS28 was also significantly reduced after 12 weeks (<i>p</i> < 0.0001). Similarly, the serum CLP concentration decreased 6 and 12 weeks after NS-PT (<i>p</i> < 0.0001). Of the patients, 100% presented lower levels of CRP and ESR (<i>p</i> < 0.0001). Overall, NS-PT reduced inflammation and disease activity, highlighting the importance of oral health in the control and treatment of systemic diseases such as RA and confirming that NS-PT effectively reduces periodontitis activity and plays a key role in modulating RA activity. Therefore, NS-PT should be considered as an adjunct treatment for RA.https://www.mdpi.com/2079-9721/12/1/12oral healthperiodontitisperiodontal treatmentinflammatory biomarkersrheumatoid arthritis |
| spellingShingle | Elena Aurora Popoca-Hernández Rita Elizabeth Martínez-Martínez Roberto Fidencio González-Amaro Perla del Carmen Niño-Moreno José Luis Ayala-Herrera Alberto Vinicio Jerezano-Domínguez Leon Francisco Espinosa-Cristóbal María de Lourdes Márquez-Corona Irene Aurora Espinosa-de Santillana Carlo Eduardo Medina-Solís Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study Diseases oral health periodontitis periodontal treatment inflammatory biomarkers rheumatoid arthritis |
| title | Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study |
| title_full | Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study |
| title_fullStr | Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study |
| title_full_unstemmed | Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study |
| title_short | Impact of Non-Surgical Periodontal Treatment on the Concentration and Level of MRP-8/14 (Calprotectin) as an Inflammatory Biomarker in Women with Periodontitis and Rheumatoid Arthritis: A Quasi-Experimental Study |
| title_sort | impact of non surgical periodontal treatment on the concentration and level of mrp 8 14 calprotectin as an inflammatory biomarker in women with periodontitis and rheumatoid arthritis a quasi experimental study |
| topic | oral health periodontitis periodontal treatment inflammatory biomarkers rheumatoid arthritis |
| url | https://www.mdpi.com/2079-9721/12/1/12 |
| work_keys_str_mv | AT elenaaurorapopocahernandez impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy AT ritaelizabethmartinezmartinez impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy AT robertofidenciogonzalezamaro impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy AT perladelcarmenninomoreno impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy AT joseluisayalaherrera impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy AT albertoviniciojerezanodominguez impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy AT leonfranciscoespinosacristobal impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy AT mariadelourdesmarquezcorona impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy AT ireneauroraespinosadesantillana impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy AT carloeduardomedinasolis impactofnonsurgicalperiodontaltreatmentontheconcentrationandlevelofmrp814calprotectinasaninflammatorybiomarkerinwomenwithperiodontitisandrheumatoidarthritisaquasiexperimentalstudy |