Baseline Vitamin D as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically Vitamin D-deficient area in North India
Background: Conflicting data suggest that Vitamin D reduces the risk of developing chronic obstructive pulmonary disease (COPD) and COPD exacerbations. Scant data are available regarding the Vitamin D status in patients with COPD in India where Vitamin D deficiency is rampant. Objectives: We set out...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2020-01-01
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| Series: | Indian Journal of Respiratory Care |
| Subjects: | |
| Online Access: | http://www.ijrconline.org/article.asp?issn=2277-9019;year=2020;volume=9;issue=1;spage=88;epage=93;aulast=Bhat |
| _version_ | 1797694420117618688 |
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| author | Mohammad Ramzan Bhat Shabir Ahmad Dar Mir Waseem Mir Nadeem |
| author_facet | Mohammad Ramzan Bhat Shabir Ahmad Dar Mir Waseem Mir Nadeem |
| author_sort | Mohammad Ramzan Bhat |
| collection | DOAJ |
| description | Background: Conflicting data suggest that Vitamin D reduces the risk of developing chronic obstructive pulmonary disease (COPD) and COPD exacerbations. Scant data are available regarding the Vitamin D status in patients with COPD in India where Vitamin D deficiency is rampant. Objectives: We set out to study the role of baseline Vitamin D on the outcome of acute exacerbation of COPD (AECOPD) in terms of exacerbations, hospitalizations, and mortality. Materials and Methods: In a prospective observational design, 147 consenting participants with AECOPD were recruited and serum Vitamin D assessed at admission. The patients were followed for 3 months for treatment outcomes in terms of mortality, readmissions and exacerbations. Standard statistical methods were used to compare the results among those with sufficient and insufficient Vitamin D status at baseline. Results: Out of 147 completely followed participants, 113 (76.9%) were deficient in Vitamin D (mean ± standard deviation = 11.79 ± 8.5 [normal 30–100 ng/ml]). Patients with low Vitamin D were found to have a significantly higher 90-day mortality than those with normal Vitamin D status (P = 0.42; hazard ratio 4.8, P = 0.032). No statistically significant differences were observed in rates of exacerbations or hospital admission. Conclusion: Patients of AECOPD having baseline Vitamin D deficiency at admission have a higher mortality than those with normal Vitamin D level. Thus, Vitamin D level can serve as a prognostic indicator of the outcome of AECOPD. Larger studies are suggested to further study the association and also determine any role of Vitamin D in the treatment of such cases. |
| first_indexed | 2024-03-12T02:57:39Z |
| format | Article |
| id | doaj.art-fb5eed4dd6de4cb3a71a3766feae3e42 |
| institution | Directory Open Access Journal |
| issn | 2277-9019 2321-4899 |
| language | English |
| last_indexed | 2024-03-12T02:57:39Z |
| publishDate | 2020-01-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Respiratory Care |
| spelling | doaj.art-fb5eed4dd6de4cb3a71a3766feae3e422023-09-03T15:12:33ZengJaypee Brothers Medical PublisherIndian Journal of Respiratory Care2277-90192321-48992020-01-0191889310.4103/ijrc.ijrc_48_19Baseline Vitamin D as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically Vitamin D-deficient area in North IndiaMohammad Ramzan BhatShabir Ahmad DarMir WaseemMir NadeemBackground: Conflicting data suggest that Vitamin D reduces the risk of developing chronic obstructive pulmonary disease (COPD) and COPD exacerbations. Scant data are available regarding the Vitamin D status in patients with COPD in India where Vitamin D deficiency is rampant. Objectives: We set out to study the role of baseline Vitamin D on the outcome of acute exacerbation of COPD (AECOPD) in terms of exacerbations, hospitalizations, and mortality. Materials and Methods: In a prospective observational design, 147 consenting participants with AECOPD were recruited and serum Vitamin D assessed at admission. The patients were followed for 3 months for treatment outcomes in terms of mortality, readmissions and exacerbations. Standard statistical methods were used to compare the results among those with sufficient and insufficient Vitamin D status at baseline. Results: Out of 147 completely followed participants, 113 (76.9%) were deficient in Vitamin D (mean ± standard deviation = 11.79 ± 8.5 [normal 30–100 ng/ml]). Patients with low Vitamin D were found to have a significantly higher 90-day mortality than those with normal Vitamin D status (P = 0.42; hazard ratio 4.8, P = 0.032). No statistically significant differences were observed in rates of exacerbations or hospital admission. Conclusion: Patients of AECOPD having baseline Vitamin D deficiency at admission have a higher mortality than those with normal Vitamin D level. Thus, Vitamin D level can serve as a prognostic indicator of the outcome of AECOPD. Larger studies are suggested to further study the association and also determine any role of Vitamin D in the treatment of such cases.http://www.ijrconline.org/article.asp?issn=2277-9019;year=2020;volume=9;issue=1;spage=88;epage=93;aulast=Bhatchronic obstructive pulmonary diseasehazard ratiomortalityvitamin d |
| spellingShingle | Mohammad Ramzan Bhat Shabir Ahmad Dar Mir Waseem Mir Nadeem Baseline Vitamin D as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically Vitamin D-deficient area in North India Indian Journal of Respiratory Care chronic obstructive pulmonary disease hazard ratio mortality vitamin d |
| title | Baseline Vitamin D as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically Vitamin D-deficient area in North India |
| title_full | Baseline Vitamin D as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically Vitamin D-deficient area in North India |
| title_fullStr | Baseline Vitamin D as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically Vitamin D-deficient area in North India |
| title_full_unstemmed | Baseline Vitamin D as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically Vitamin D-deficient area in North India |
| title_short | Baseline Vitamin D as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically Vitamin D-deficient area in North India |
| title_sort | baseline vitamin d as a predictor of mortality among hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in an endemically vitamin d deficient area in north india |
| topic | chronic obstructive pulmonary disease hazard ratio mortality vitamin d |
| url | http://www.ijrconline.org/article.asp?issn=2277-9019;year=2020;volume=9;issue=1;spage=88;epage=93;aulast=Bhat |
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