The challenges and opportunities of scRNA-seq in COVID-19 research and clinical translation
Abstract The application of single-cell RNA sequencing in COVID-19 research has greatly improved our understanding of COVID-19 pathogenesis and immunological characteristics. In this commentary, we discuss the current challenges, limitations, and perspectives in harnessing the power of single-cell R...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-022-01923-x |
| _version_ | 1811292149266776064 |
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| author | Wendao Liu Xiaohua Ye Zhiqiang An Zhongming Zhao |
| author_facet | Wendao Liu Xiaohua Ye Zhiqiang An Zhongming Zhao |
| author_sort | Wendao Liu |
| collection | DOAJ |
| description | Abstract The application of single-cell RNA sequencing in COVID-19 research has greatly improved our understanding of COVID-19 pathogenesis and immunological characteristics. In this commentary, we discuss the current challenges, limitations, and perspectives in harnessing the power of single-cell RNA sequencing to accelerate both basic research and therapeutic development for COVID-19 and other emerging infectious diseases. |
| first_indexed | 2024-04-13T04:41:03Z |
| format | Article |
| id | doaj.art-fb605d25e2cc4dcbabfe8610e8788c0a |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-13T04:41:03Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-fb605d25e2cc4dcbabfe8610e8788c0a2022-12-22T03:02:01ZengBMCVirology Journal1743-422X2022-12-011911410.1186/s12985-022-01923-xThe challenges and opportunities of scRNA-seq in COVID-19 research and clinical translationWendao Liu0Xiaohua Ye1Zhiqiang An2Zhongming Zhao3Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at HoustonTexas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at HoustonMD Anderson Cancer Center UTHealth Graduate School of Biomedical SciencesCenter for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at HoustonAbstract The application of single-cell RNA sequencing in COVID-19 research has greatly improved our understanding of COVID-19 pathogenesis and immunological characteristics. In this commentary, we discuss the current challenges, limitations, and perspectives in harnessing the power of single-cell RNA sequencing to accelerate both basic research and therapeutic development for COVID-19 and other emerging infectious diseases.https://doi.org/10.1186/s12985-022-01923-xCOVID-19SARS-CoV-2Single-cell RNA sequencingCOVID-19 sequelaSingle-cell VDJ sequencing |
| spellingShingle | Wendao Liu Xiaohua Ye Zhiqiang An Zhongming Zhao The challenges and opportunities of scRNA-seq in COVID-19 research and clinical translation Virology Journal COVID-19 SARS-CoV-2 Single-cell RNA sequencing COVID-19 sequela Single-cell VDJ sequencing |
| title | The challenges and opportunities of scRNA-seq in COVID-19 research and clinical translation |
| title_full | The challenges and opportunities of scRNA-seq in COVID-19 research and clinical translation |
| title_fullStr | The challenges and opportunities of scRNA-seq in COVID-19 research and clinical translation |
| title_full_unstemmed | The challenges and opportunities of scRNA-seq in COVID-19 research and clinical translation |
| title_short | The challenges and opportunities of scRNA-seq in COVID-19 research and clinical translation |
| title_sort | challenges and opportunities of scrna seq in covid 19 research and clinical translation |
| topic | COVID-19 SARS-CoV-2 Single-cell RNA sequencing COVID-19 sequela Single-cell VDJ sequencing |
| url | https://doi.org/10.1186/s12985-022-01923-x |
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