Clinical immunity in discharged medical patients with COVID-19
Background: Most studies on SARS-CoV-2 infection show that people who have recovered from COVID-19 have antibodies to the virus. No study has evaluated whether the presence of antibodies to SARS-CoV-2 confers immunity to the infection relapse but however, to date, no human reinfections with SARS-CoV...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220306238 |
| _version_ | 1818213566857084928 |
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| author | Nicola Mumoli Josè Vitale Antonino Mazzone |
| author_facet | Nicola Mumoli Josè Vitale Antonino Mazzone |
| author_sort | Nicola Mumoli |
| collection | DOAJ |
| description | Background: Most studies on SARS-CoV-2 infection show that people who have recovered from COVID-19 have antibodies to the virus. No study has evaluated whether the presence of antibodies to SARS-CoV-2 confers immunity to the infection relapse but however, to date, no human reinfections with SARS-CoV-2 have been confirmed. Material and methods: In our prospective, multicenter, cohort study we investigated within three months all patients, with confirmed COVID-19, discharged from two Hospitals (Legnano and Magenta Hospitals), in an area of Italy severely affected by the infection. Telephone follow-up at 1 and 2 months and clinical contact within 3 months was initiated; demographic, clinical, radiologic and laboratory data were recorded in electronic medical records and updated. Results: Of 1081 patients involved, 804 (74.3%) were discharged alive. For all these patients we obtained follow-up data. At 1 and 2 months none has died and none has had any signs of recurrence of infectious at both telephone interview and clinical visit. Conclusion: Our clinical observation have confirmed two basic points: the reinfection is very unlikely and any antibody immunity protects against recurrence, at least in the short term. |
| first_indexed | 2024-12-12T06:06:20Z |
| format | Article |
| id | doaj.art-fb616efe3eb1416f9c37068b14f8e60b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T06:06:20Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-fb616efe3eb1416f9c37068b14f8e60b2022-12-22T00:35:17ZengElsevierInternational Journal of Infectious Diseases1201-97122020-10-0199229230Clinical immunity in discharged medical patients with COVID-19Nicola Mumoli0Josè Vitale1Antonino Mazzone2Corresponding author at: Department of Internal Medicine, Ospedale Fornaroli, via Donatori Sangue, 50, 20013 Magenta, MI, Italy.; Department of Internal Medicine, Ospedale di Legnano e Magenta, ASST Ovest Milanese, MI, ItalyDepartment of Internal Medicine, Ospedale di Legnano e Magenta, ASST Ovest Milanese, MI, ItalyDepartment of Internal Medicine, Ospedale di Legnano e Magenta, ASST Ovest Milanese, MI, ItalyBackground: Most studies on SARS-CoV-2 infection show that people who have recovered from COVID-19 have antibodies to the virus. No study has evaluated whether the presence of antibodies to SARS-CoV-2 confers immunity to the infection relapse but however, to date, no human reinfections with SARS-CoV-2 have been confirmed. Material and methods: In our prospective, multicenter, cohort study we investigated within three months all patients, with confirmed COVID-19, discharged from two Hospitals (Legnano and Magenta Hospitals), in an area of Italy severely affected by the infection. Telephone follow-up at 1 and 2 months and clinical contact within 3 months was initiated; demographic, clinical, radiologic and laboratory data were recorded in electronic medical records and updated. Results: Of 1081 patients involved, 804 (74.3%) were discharged alive. For all these patients we obtained follow-up data. At 1 and 2 months none has died and none has had any signs of recurrence of infectious at both telephone interview and clinical visit. Conclusion: Our clinical observation have confirmed two basic points: the reinfection is very unlikely and any antibody immunity protects against recurrence, at least in the short term.http://www.sciencedirect.com/science/article/pii/S1201971220306238COVID-19ImmunitySARS-CoV-2 |
| spellingShingle | Nicola Mumoli Josè Vitale Antonino Mazzone Clinical immunity in discharged medical patients with COVID-19 International Journal of Infectious Diseases COVID-19 Immunity SARS-CoV-2 |
| title | Clinical immunity in discharged medical patients with COVID-19 |
| title_full | Clinical immunity in discharged medical patients with COVID-19 |
| title_fullStr | Clinical immunity in discharged medical patients with COVID-19 |
| title_full_unstemmed | Clinical immunity in discharged medical patients with COVID-19 |
| title_short | Clinical immunity in discharged medical patients with COVID-19 |
| title_sort | clinical immunity in discharged medical patients with covid 19 |
| topic | COVID-19 Immunity SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220306238 |
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