Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2
The COVID-19 pandemic affected over 130 million individuals during more than one year. Due to the overload of health-care services, a great number of people were treated as outpatients, many of them subsequently developing post-acute COVID-19 syndrome. Our study was conducted on 150 subjects without...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Online Access: | https://www.mdpi.com/2079-7737/10/6/469 |
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| author | Cristina Tudoran Mariana Tudoran Gheorghe Nicusor Pop Catalina Giurgi-Oncu Talida Georgiana Cut Voichita Elena Lazureanu Cristian Oancea Florina Parv Tudor Ciocarlie Felix Bende |
| author_facet | Cristina Tudoran Mariana Tudoran Gheorghe Nicusor Pop Catalina Giurgi-Oncu Talida Georgiana Cut Voichita Elena Lazureanu Cristian Oancea Florina Parv Tudor Ciocarlie Felix Bende |
| author_sort | Cristina Tudoran |
| collection | DOAJ |
| description | The COVID-19 pandemic affected over 130 million individuals during more than one year. Due to the overload of health-care services, a great number of people were treated as outpatients, many of them subsequently developing post-acute COVID-19 syndrome. Our study was conducted on 150 subjects without a history of cardiovascular diseases, treated as outpatients for a mild/moderate form of COVID-19 4 to 12 weeks prior to study inclusion, and who were diagnosed with post-acute COVID-19 and attended a cardiology evaluation with transthoracic echocardiography (TTE) for persisting symptoms. We detected various cardiac abnormalities in 38 subjects (25.33%), including pulmonary hypertension (9.33%), impaired left ventricular performance (8.66%), diastolic dysfunction (14%) and/or evidence of pericarditis (10%). We highlighted statistically significant correlations between the intensity of symptoms and quality of life scores with the severity of initial pulmonary injury, the number of weeks since COVID-19 and with TTE parameters characterizing the systolic and diastolic performance and pulmonary hypertension (<i>p</i> < 0.001). (Post-acute COVID-19 is a complex syndrome characterized by various symptoms, the intensity of which seem to be related to the severity and the time elapsed since the acute infection, and with persisting cardiac abnormalities. |
| first_indexed | 2024-03-10T11:03:00Z |
| format | Article |
| id | doaj.art-fb619fdbc18b44e49511dbe04cfbf08c |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T11:03:00Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-fb619fdbc18b44e49511dbe04cfbf08c2023-11-21T21:26:23ZengMDPI AGBiology2079-77372021-05-0110646910.3390/biology10060469Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2Cristina Tudoran0Mariana Tudoran1Gheorghe Nicusor Pop2Catalina Giurgi-Oncu3Talida Georgiana Cut4Voichita Elena Lazureanu5Cristian Oancea6Florina Parv7Tudor Ciocarlie8Felix Bende9Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment VI, Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaCounty Emergency Hospital Timisoara, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaDepartment VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, RomaniaCounty Emergency Hospital Timisoara, 300041 Timisoara, RomaniaThe COVID-19 pandemic affected over 130 million individuals during more than one year. Due to the overload of health-care services, a great number of people were treated as outpatients, many of them subsequently developing post-acute COVID-19 syndrome. Our study was conducted on 150 subjects without a history of cardiovascular diseases, treated as outpatients for a mild/moderate form of COVID-19 4 to 12 weeks prior to study inclusion, and who were diagnosed with post-acute COVID-19 and attended a cardiology evaluation with transthoracic echocardiography (TTE) for persisting symptoms. We detected various cardiac abnormalities in 38 subjects (25.33%), including pulmonary hypertension (9.33%), impaired left ventricular performance (8.66%), diastolic dysfunction (14%) and/or evidence of pericarditis (10%). We highlighted statistically significant correlations between the intensity of symptoms and quality of life scores with the severity of initial pulmonary injury, the number of weeks since COVID-19 and with TTE parameters characterizing the systolic and diastolic performance and pulmonary hypertension (<i>p</i> < 0.001). (Post-acute COVID-19 is a complex syndrome characterized by various symptoms, the intensity of which seem to be related to the severity and the time elapsed since the acute infection, and with persisting cardiac abnormalities.https://www.mdpi.com/2079-7737/10/6/469COVID-19post-acute COVID-19 syndromecardiovascular abnormalitiestransthoracic echocardiographyquality of life |
| spellingShingle | Cristina Tudoran Mariana Tudoran Gheorghe Nicusor Pop Catalina Giurgi-Oncu Talida Georgiana Cut Voichita Elena Lazureanu Cristian Oancea Florina Parv Tudor Ciocarlie Felix Bende Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2 Biology COVID-19 post-acute COVID-19 syndrome cardiovascular abnormalities transthoracic echocardiography quality of life |
| title | Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2 |
| title_full | Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2 |
| title_fullStr | Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2 |
| title_full_unstemmed | Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2 |
| title_short | Associations between the Severity of the Post-Acute COVID-19 Syndrome and Echocardiographic Abnormalities in Previously Healthy Outpatients Following Infection with SARS-CoV-2 |
| title_sort | associations between the severity of the post acute covid 19 syndrome and echocardiographic abnormalities in previously healthy outpatients following infection with sars cov 2 |
| topic | COVID-19 post-acute COVID-19 syndrome cardiovascular abnormalities transthoracic echocardiography quality of life |
| url | https://www.mdpi.com/2079-7737/10/6/469 |
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