Association of Lipid Accumulation Product with Insulin Resistance in Type 2 Diabetes Mellitus: A Cross-sectional Study
Introduction: The increased incidence of diabetes and Cardiovascular Disease (CVD) is attributed to the rising obesity rates, which is one of the major factors contributing to Insulin Resistance (IR). Although there is a close relationship between obesity and IR, not all cases of obesity lead to...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/18822/68222_CE[Ra1]_F[SK]_QC(KK_RDW_IS)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
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| author | P Vijayalakshmi HS Manjula SMR Usha |
| author_facet | P Vijayalakshmi HS Manjula SMR Usha |
| author_sort | P Vijayalakshmi |
| collection | DOAJ |
| description | Introduction: The increased incidence of diabetes and
Cardiovascular Disease (CVD) is attributed to the rising obesity
rates, which is one of the major factors contributing to Insulin
Resistance (IR). Although there is a close relationship between
obesity and IR, not all cases of obesity lead to cardiometabolic
complications. Visceral fat is considered to be the primary
cause of IR. Lipid Accumulation Product (LAP) is postulated as
a new continuous biomarker of visceral adiposity.
Aim: To determine the association between LAP and IR in
T2DM.
Materials and Methods: This institution-based cross-sectional
study was conducted over a period of three months at the
Department of Biochemistry, Rajarajeswari Medical College and
Hospital in Bengaluru, Karnataka, India. A total of 60 Type 2
diabetic patients (including newly diagnosed and known cases)
were recruited as cases, along with 30 healthy controls. Height,
weight, and Waist Circumference (WC) were measured. Fasting
blood samples were collected for laboratory biochemical
estimation of glucose, Total Cholesterol (TC), Triglycerides (TG),
High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL),
and fasting insulin. Statistical analysis for continuous variables
was performed using unpaired Student’s t-test, and Analysis of
Variance (ANOVA) test was used for group comparisons.
Results: Fasting serum insulin (p-value=0.007), Homeostatic
Model Assessment for Insulin Resistance (HOMA-IR)
(p-value=0.001), and LAP index (p-value<0.001) were significantly
higher in the case group. LAP index was divided into quartiles,
Insulin and HOMA-IR showed statistical significance across the
quartiles (p-value=0.005). The lipid profile analysis across LAP
quartiles revealed a progressive increase in TG levels (p<0.001)
and a decrease in HDL levels from Q1 to Q4 quartiles.
Conclusion: The study concludes that increased LAP levels are
associated with IR in T2DM. LAP can serve as a useful marker
for cardiometabolic risk in early-stage T2DM, enabling better
disease stratification for improved prognosis. |
| first_indexed | 2024-03-08T22:02:42Z |
| format | Article |
| id | doaj.art-fb620c4d1dff4a82a0ce247f223ab0e9 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-08T22:02:42Z |
| publishDate | 2023-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-fb620c4d1dff4a82a0ce247f223ab0e92023-12-19T11:37:23ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-12-011712060910.7860/JCDR/2023/68222.18822Association of Lipid Accumulation Product with Insulin Resistance in Type 2 Diabetes Mellitus: A Cross-sectional StudyP Vijayalakshmi0HS Manjula1SMR Usha2Associate Professor, Department of Biochemistry, The Oxford Medical College Hospital and Research Centre, Bangalore,Karnataka, India.Associate Professor, Department of Biochemistry, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India.Professor, Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bangalore, Karnataka, India.Introduction: The increased incidence of diabetes and Cardiovascular Disease (CVD) is attributed to the rising obesity rates, which is one of the major factors contributing to Insulin Resistance (IR). Although there is a close relationship between obesity and IR, not all cases of obesity lead to cardiometabolic complications. Visceral fat is considered to be the primary cause of IR. Lipid Accumulation Product (LAP) is postulated as a new continuous biomarker of visceral adiposity. Aim: To determine the association between LAP and IR in T2DM. Materials and Methods: This institution-based cross-sectional study was conducted over a period of three months at the Department of Biochemistry, Rajarajeswari Medical College and Hospital in Bengaluru, Karnataka, India. A total of 60 Type 2 diabetic patients (including newly diagnosed and known cases) were recruited as cases, along with 30 healthy controls. Height, weight, and Waist Circumference (WC) were measured. Fasting blood samples were collected for laboratory biochemical estimation of glucose, Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), and fasting insulin. Statistical analysis for continuous variables was performed using unpaired Student’s t-test, and Analysis of Variance (ANOVA) test was used for group comparisons. Results: Fasting serum insulin (p-value=0.007), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p-value=0.001), and LAP index (p-value<0.001) were significantly higher in the case group. LAP index was divided into quartiles, Insulin and HOMA-IR showed statistical significance across the quartiles (p-value=0.005). The lipid profile analysis across LAP quartiles revealed a progressive increase in TG levels (p<0.001) and a decrease in HDL levels from Q1 to Q4 quartiles. Conclusion: The study concludes that increased LAP levels are associated with IR in T2DM. LAP can serve as a useful marker for cardiometabolic risk in early-stage T2DM, enabling better disease stratification for improved prognosis.https://www.jcdr.net/articles/PDF/18822/68222_CE[Ra1]_F[SK]_QC(KK_RDW_IS)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdfdyslipidaemiainsulinobesitytriglyceridewaist circumference |
| spellingShingle | P Vijayalakshmi HS Manjula SMR Usha Association of Lipid Accumulation Product with Insulin Resistance in Type 2 Diabetes Mellitus: A Cross-sectional Study Journal of Clinical and Diagnostic Research dyslipidaemia insulin obesity triglyceride waist circumference |
| title | Association of Lipid Accumulation Product with Insulin Resistance in Type 2 Diabetes Mellitus: A Cross-sectional Study |
| title_full | Association of Lipid Accumulation Product with Insulin Resistance in Type 2 Diabetes Mellitus: A Cross-sectional Study |
| title_fullStr | Association of Lipid Accumulation Product with Insulin Resistance in Type 2 Diabetes Mellitus: A Cross-sectional Study |
| title_full_unstemmed | Association of Lipid Accumulation Product with Insulin Resistance in Type 2 Diabetes Mellitus: A Cross-sectional Study |
| title_short | Association of Lipid Accumulation Product with Insulin Resistance in Type 2 Diabetes Mellitus: A Cross-sectional Study |
| title_sort | association of lipid accumulation product with insulin resistance in type 2 diabetes mellitus a cross sectional study |
| topic | dyslipidaemia insulin obesity triglyceride waist circumference |
| url | https://www.jcdr.net/articles/PDF/18822/68222_CE[Ra1]_F[SK]_QC(KK_RDW_IS)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
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