Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet

Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet

BYL719 (alpelisib) is a small molecule inhibitor of PI3K p110α developed for cancer therapy. Targeted suppression of PI3K has led to lifespan extension in rodents and model organisms. If PI3K inhibitors are to be considered as an aging therapeutic, it is important to understand the potential consequ...

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Bibliographic Details
Main Authors: Christopher P. Hedges, Jordi Boix, Jagdish K. Jaiswal, Bhoopika Shetty, Peter R. Shepherd, Troy L. Merry
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomolecules
Subjects:
insulin signaling
aging
BYL-719
glucose tolerance
pharmacokinetics
Online Access:https://www.mdpi.com/2218-273X/11/2/150

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