Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil
Objective: Compare the anti-T. gondii IgG titer between HIV-1 infected and non HIV-1 infected pregnant women and report three cases of congenital toxoplasmosis resulting from reactivation of infection during pregnancy of HIV-1 infected women. Methods: This study was conducted among 2,270 pregnant wo...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-03-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867012703008 |
| _version_ | 1818380230780256256 |
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| author | Márcia Antunes Fernandes Giovanni Inácio Batista Juliano da Costa Silveira Carlos Ivete Martins Gomes Kátia Martins Lopes de Azevedo Sérgio Setúbal Solange Artimos de Oliveira Luis Guilhermo Coca Velarde Claudete Aparecida Araújo Cardoso |
| author_facet | Márcia Antunes Fernandes Giovanni Inácio Batista Juliano da Costa Silveira Carlos Ivete Martins Gomes Kátia Martins Lopes de Azevedo Sérgio Setúbal Solange Artimos de Oliveira Luis Guilhermo Coca Velarde Claudete Aparecida Araújo Cardoso |
| author_sort | Márcia Antunes Fernandes |
| collection | DOAJ |
| description | Objective: Compare the anti-T. gondii IgG titer between HIV-1 infected and non HIV-1 infected pregnant women and report three cases of congenital toxoplasmosis resulting from reactivation of infection during pregnancy of HIV-1 infected women. Methods: This study was conducted among 2,270 pregnant women with chronic Toxoplasma gondii infection (absence of IgM and presence of IgG), including 82 HIV-1 infected and 2,188 non-infected women. Results: The average anti-T. gondii IgG titer was 127 for the 2,188 non-HIV-1 infected women, and 227 for the 82 HIV-1-infected women (p = 0,007). These results suggested that higher anti-T. gondii IgG titers in HIV-1-infected pregnant women may not be indicative of an elevated risk for fetal infection. In this study three cases of congenital toxoplasmosis that resulted from infection reactivation during pregnancy of HIV-1-infected women were manifested by fetal death, symptomatic infection, and infant without symptoms, respectively. In two of these women, a ten-fold increase in IgG levels above used cutoff was observed (2,320 UI/mL and 3,613 UI/mL, respectively). In the third pregnant women anti-T. gondii IgG titers during pregnancy did not rise despite the occurrence of congenital toxoplasmosis (204; 198; 172 UI/mL). Conclusions: Congenital toxoplasmosis resulting reactivation of infection during pregnancy in the studied group leads us to believe that it is a public health problem, especially in our population, in which seroprevalence of T. gondii infections is high. These findings also suggest that special attention is necessary during pregnancy, because the serologic diagnosis may not be indicative of toxoplasmosis reactivation. Keywords: Toxoplasma, Toxoplasmosis, congenital, HIV infections |
| first_indexed | 2024-12-14T02:15:23Z |
| format | Article |
| id | doaj.art-fb65e69bd98e42789e2fc5438f75fe04 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-14T02:15:23Z |
| publishDate | 2012-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-fb65e69bd98e42789e2fc5438f75fe042022-12-21T23:20:38ZengElsevierBrazilian Journal of Infectious Diseases1413-86702012-03-01162170174Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, BrazilMárcia Antunes Fernandes0Giovanni Inácio Batista1Juliano da Costa Silveira Carlos2Ivete Martins Gomes3Kátia Martins Lopes de Azevedo4Sérgio Setúbal5Solange Artimos de Oliveira6Luis Guilhermo Coca Velarde7Claudete Aparecida Araújo Cardoso8Maternal and Child Department, Medical School, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, BrazilMedical School, Universidade Federal Fluminense, Niterói, RJ, BrazilMedical School, Universidade Federal Fluminense, Niterói, RJ, BrazilInfectious and Parasitic Diseases, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, BrazilInfectious and Parasitic Diseases, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, BrazilInfectious and Parasitic Diseases, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, BrazilInfectious and Parasitic Diseases, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, BrazilInstitute of Mathematics and Statistics, Universidade Federal Fluminense, Niterói, RJ, BrazilMaternal and Child Department, Medical School, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil; Corresponding author at: Rua Marquês de Paraná, 303, Centro, Niterói, RJ, 24033-900, Brazil.Objective: Compare the anti-T. gondii IgG titer between HIV-1 infected and non HIV-1 infected pregnant women and report three cases of congenital toxoplasmosis resulting from reactivation of infection during pregnancy of HIV-1 infected women. Methods: This study was conducted among 2,270 pregnant women with chronic Toxoplasma gondii infection (absence of IgM and presence of IgG), including 82 HIV-1 infected and 2,188 non-infected women. Results: The average anti-T. gondii IgG titer was 127 for the 2,188 non-HIV-1 infected women, and 227 for the 82 HIV-1-infected women (p = 0,007). These results suggested that higher anti-T. gondii IgG titers in HIV-1-infected pregnant women may not be indicative of an elevated risk for fetal infection. In this study three cases of congenital toxoplasmosis that resulted from infection reactivation during pregnancy of HIV-1-infected women were manifested by fetal death, symptomatic infection, and infant without symptoms, respectively. In two of these women, a ten-fold increase in IgG levels above used cutoff was observed (2,320 UI/mL and 3,613 UI/mL, respectively). In the third pregnant women anti-T. gondii IgG titers during pregnancy did not rise despite the occurrence of congenital toxoplasmosis (204; 198; 172 UI/mL). Conclusions: Congenital toxoplasmosis resulting reactivation of infection during pregnancy in the studied group leads us to believe that it is a public health problem, especially in our population, in which seroprevalence of T. gondii infections is high. These findings also suggest that special attention is necessary during pregnancy, because the serologic diagnosis may not be indicative of toxoplasmosis reactivation. Keywords: Toxoplasma, Toxoplasmosis, congenital, HIV infectionshttp://www.sciencedirect.com/science/article/pii/S1413867012703008 |
| spellingShingle | Márcia Antunes Fernandes Giovanni Inácio Batista Juliano da Costa Silveira Carlos Ivete Martins Gomes Kátia Martins Lopes de Azevedo Sérgio Setúbal Solange Artimos de Oliveira Luis Guilhermo Coca Velarde Claudete Aparecida Araújo Cardoso Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil Brazilian Journal of Infectious Diseases |
| title | Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil |
| title_full | Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil |
| title_fullStr | Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil |
| title_full_unstemmed | Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil |
| title_short | Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil |
| title_sort | toxoplasma gondii antibody profile in hiv 1 infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in rio de janeiro brazil |
| url | http://www.sciencedirect.com/science/article/pii/S1413867012703008 |
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