Ageing: from inflammation to cancer
Abstract Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Immunity & Ageing |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12979-017-0112-5 |
| _version_ | 1828432941809664000 |
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| author | Giulia C. Leonardi Giulia Accardi Roberto Monastero Ferdinando Nicoletti Massimo Libra |
| author_facet | Giulia C. Leonardi Giulia Accardi Roberto Monastero Ferdinando Nicoletti Massimo Libra |
| author_sort | Giulia C. Leonardi |
| collection | DOAJ |
| description | Abstract Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transformation to metastasis. Therefore, inflammaging may represent the biological phenomena able to couple ageing process with cancer development. Here we review the molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development. |
| first_indexed | 2024-12-10T18:28:09Z |
| format | Article |
| id | doaj.art-fb67f423380b49df9bb7e873a4ea4e27 |
| institution | Directory Open Access Journal |
| issn | 1742-4933 |
| language | English |
| last_indexed | 2024-12-10T18:28:09Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj.art-fb67f423380b49df9bb7e873a4ea4e272022-12-22T01:38:01ZengBMCImmunity & Ageing1742-49332018-01-011511710.1186/s12979-017-0112-5Ageing: from inflammation to cancerGiulia C. Leonardi0Giulia Accardi1Roberto Monastero2Ferdinando Nicoletti3Massimo Libra4Department of Biomedical and Biotechnological Sciences, Pathology and Oncology Section, University of CataniaDepartment of Pathobiology and Medical Biotechnologies, Immunosenescence and Ageing Group, University of PalermoDepartment of Experimental Biomedicine and Clinical Neurosciences, Neurology Section, University of PalermoDepartment of Biomedical and Biotechnological Sciences, Pathology and Oncology Section, University of CataniaDepartment of Biomedical and Biotechnological Sciences, Pathology and Oncology Section, University of CataniaAbstract Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transformation to metastasis. Therefore, inflammaging may represent the biological phenomena able to couple ageing process with cancer development. Here we review the molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development.http://link.springer.com/article/10.1186/s12979-017-0112-5AgeingCancerDAMPsInflammationMicrobiotaMiRna |
| spellingShingle | Giulia C. Leonardi Giulia Accardi Roberto Monastero Ferdinando Nicoletti Massimo Libra Ageing: from inflammation to cancer Immunity & Ageing Ageing Cancer DAMPs Inflammation Microbiota MiRna |
| title | Ageing: from inflammation to cancer |
| title_full | Ageing: from inflammation to cancer |
| title_fullStr | Ageing: from inflammation to cancer |
| title_full_unstemmed | Ageing: from inflammation to cancer |
| title_short | Ageing: from inflammation to cancer |
| title_sort | ageing from inflammation to cancer |
| topic | Ageing Cancer DAMPs Inflammation Microbiota MiRna |
| url | http://link.springer.com/article/10.1186/s12979-017-0112-5 |
| work_keys_str_mv | AT giuliacleonardi ageingfrominflammationtocancer AT giuliaaccardi ageingfrominflammationtocancer AT robertomonastero ageingfrominflammationtocancer AT ferdinandonicoletti ageingfrominflammationtocancer AT massimolibra ageingfrominflammationtocancer |