Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae in an ovalbumin-induced murine model of asthma
ABSTRACTAsthma is a disease-related allergic response characterized by the accumulation of inflammatory cells in airway tissue. Protaetia brevitarsis seulensis larvae are known for their nutritional value and have been used in food; however, it is unknown whether they exert protective effects in a m...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Food and Agricultural Immunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2023.2280502 |
| _version_ | 1827630182418087936 |
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| author | Hyun-Yong Kim Hyeon-Hwa Nam Young Hye Seo Sueun Lee Jin Mi Chun Jun Lee Jun Ho Song Kon-Young Ji Sung-Wook Chae Bohye Kim Changjong Moon Yun-Soo Seo Joong-Sun Kim |
| author_facet | Hyun-Yong Kim Hyeon-Hwa Nam Young Hye Seo Sueun Lee Jin Mi Chun Jun Lee Jun Ho Song Kon-Young Ji Sung-Wook Chae Bohye Kim Changjong Moon Yun-Soo Seo Joong-Sun Kim |
| author_sort | Hyun-Yong Kim |
| collection | DOAJ |
| description | ABSTRACTAsthma is a disease-related allergic response characterized by the accumulation of inflammatory cells in airway tissue. Protaetia brevitarsis seulensis larvae are known for their nutritional value and have been used in food; however, it is unknown whether they exert protective effects in a murine ovalbumin (OVA)-induced asthmatic model. We investigated the protective effects of an aqueous extract of P. brevitarsis seulensis larvae (PBE) against OVA-induced asthma by performing histopathological analysis and measuring inflammatory mediators in bronchoalveolar lavage fluid using enzyme-linked immunosorbent assay and flow cytometry. Asthmatic symptoms were attenuated by PBE, as indicated by decreased inflammation in lung tissue and decreased levels of inflammatory cells, inflammatory cytokines, and Th2 cell activation. Additionally, four out of six major metabolites isolated from P. brevitarsis seulensis attenuated Th2 cell activation, indicating that PBE attenuates asthmatic inflammation by regulating Th2 cell activation. Therefore, our findings support PBE as a pharmacological candidate for asthma treatment. |
| first_indexed | 2024-03-09T14:02:29Z |
| format | Article |
| id | doaj.art-fb6e6cfc242c423c917f041a07fe56da |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-03-09T14:02:29Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-fb6e6cfc242c423c917f041a07fe56da2023-11-30T06:57:34ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432023-12-0134110.1080/09540105.2023.2280502Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae in an ovalbumin-induced murine model of asthmaHyun-Yong Kim0Hyeon-Hwa Nam1Young Hye Seo2Sueun Lee3Jin Mi Chun4Jun Lee5Jun Ho Song6Kon-Young Ji7Sung-Wook Chae8Bohye Kim9Changjong Moon10Yun-Soo Seo11Joong-Sun Kim12Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, Republic of KoreaHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, Republic of KoreaHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, Republic of KoreaHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, Republic of KoreaHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, Republic of KoreaHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, Republic of KoreaDepartment of Biology, Chungbuk National University, Cheongju, Republic of KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaCollege of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University, Gwangju, Republic of KoreaCollege of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University, Gwangju, Republic of KoreaHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, Republic of KoreaHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, Republic of KoreaABSTRACTAsthma is a disease-related allergic response characterized by the accumulation of inflammatory cells in airway tissue. Protaetia brevitarsis seulensis larvae are known for their nutritional value and have been used in food; however, it is unknown whether they exert protective effects in a murine ovalbumin (OVA)-induced asthmatic model. We investigated the protective effects of an aqueous extract of P. brevitarsis seulensis larvae (PBE) against OVA-induced asthma by performing histopathological analysis and measuring inflammatory mediators in bronchoalveolar lavage fluid using enzyme-linked immunosorbent assay and flow cytometry. Asthmatic symptoms were attenuated by PBE, as indicated by decreased inflammation in lung tissue and decreased levels of inflammatory cells, inflammatory cytokines, and Th2 cell activation. Additionally, four out of six major metabolites isolated from P. brevitarsis seulensis attenuated Th2 cell activation, indicating that PBE attenuates asthmatic inflammation by regulating Th2 cell activation. Therefore, our findings support PBE as a pharmacological candidate for asthma treatment.https://www.tandfonline.com/doi/10.1080/09540105.2023.2280502Protaetia brevitarsis seulensis: allergy: asthma: T cell activation: type 2 helper T cells |
| spellingShingle | Hyun-Yong Kim Hyeon-Hwa Nam Young Hye Seo Sueun Lee Jin Mi Chun Jun Lee Jun Ho Song Kon-Young Ji Sung-Wook Chae Bohye Kim Changjong Moon Yun-Soo Seo Joong-Sun Kim Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae in an ovalbumin-induced murine model of asthma Food and Agricultural Immunology Protaetia brevitarsis seulensis: allergy: asthma: T cell activation: type 2 helper T cells |
| title | Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae in an ovalbumin-induced murine model of asthma |
| title_full | Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae in an ovalbumin-induced murine model of asthma |
| title_fullStr | Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae in an ovalbumin-induced murine model of asthma |
| title_full_unstemmed | Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae in an ovalbumin-induced murine model of asthma |
| title_short | Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae in an ovalbumin-induced murine model of asthma |
| title_sort | protective effects of an aqueous extract of protaetia brevitarsis seulensis larvae in an ovalbumin induced murine model of asthma |
| topic | Protaetia brevitarsis seulensis: allergy: asthma: T cell activation: type 2 helper T cells |
| url | https://www.tandfonline.com/doi/10.1080/09540105.2023.2280502 |
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