Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets
Selective Laser Sintering (SLS) has the potential to offer a more accurate alternative to current-practice manipulation of oral dosage forms for pediatric, geriatric, and dysphagia-suffering patient groups. In order to create the best possible dosage forms for these patient groups, an in-depth look...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Drug Delivery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fddev.2024.1358336/full |
| _version_ | 1797272660074299392 |
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| author | Valerie R. Levine Christos S. Katsiotis Maria Strømme Julian Quodbach Jonas Lindh |
| author_facet | Valerie R. Levine Christos S. Katsiotis Maria Strømme Julian Quodbach Jonas Lindh |
| author_sort | Valerie R. Levine |
| collection | DOAJ |
| description | Selective Laser Sintering (SLS) has the potential to offer a more accurate alternative to current-practice manipulation of oral dosage forms for pediatric, geriatric, and dysphagia-suffering patient groups. In order to create the best possible dosage forms for these patient groups, an in-depth look into how a dosage forms geometry impacts the overall properties is essential. In this study, the impact of geometry on SLS manufactured oral dosage forms on the tablet’s microstructure, actual-to-theoretical volume, mass deviation, disintegration, and dissolution was investigated. Three different shapes; cylinder, hollow cylinder, and conical frustum with similar surface area (SA), as well as three cylinders with different diameters, were investigated. The results indicate that the geometry has an impact on the mass uniformity, resultant volume, disintegration, and dissolution properties of the tablets. The mass uniformity analysis of the tablets provided the most variation between tablets of different sizes, with more uniformity for tablets with similar SA-to-volume ratio (SA/V). When examining the actual-to-theoretical volume of the tablets, a greater variance between the actual and theoretical volumes for shapes with higher overall SA was observed. The values found are approximately 1.05 for the three differently sized cylinders, 1.23 for the conical frustum, and 1.44 for the hollow cylinder, following this trend. Disintegration data supported a link between SA/V and average disintegration time, observed with the tablet of the highest SA/V disintegrating in 12 s and the tablet with the lowest SA/V disintegrating in 58 s. Dissolution results also indicated a strong dependence on SA/V. Hence, when novel ways to produce oral dosage form tablets become available by additive manufacturing, such as SLS, both geometry and SA/V must be taken into consideration in the tablet design process to ensure appropriate release kinetics and dosing standards. |
| first_indexed | 2024-03-07T14:32:33Z |
| format | Article |
| id | doaj.art-fb6f040665454cd4aeb5f16ee990950d |
| institution | Directory Open Access Journal |
| issn | 2674-0850 |
| language | English |
| last_indexed | 2024-03-07T14:32:33Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Drug Delivery |
| spelling | doaj.art-fb6f040665454cd4aeb5f16ee990950d2024-03-06T04:23:15ZengFrontiers Media S.A.Frontiers in Drug Delivery2674-08502024-03-01410.3389/fddev.2024.13583361358336Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tabletsValerie R. Levine0Christos S. Katsiotis1Maria Strømme2Julian Quodbach3Jonas Lindh4Division of Nanotechnology and Functional Materials, Department of Material Science and Engineering, Uppsala University, Uppsala, SwedenDivision of Nanotechnology and Functional Materials, Department of Material Science and Engineering, Uppsala University, Uppsala, SwedenDivision of Nanotechnology and Functional Materials, Department of Material Science and Engineering, Uppsala University, Uppsala, SwedenDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, NetherlandsDivision of Nanotechnology and Functional Materials, Department of Material Science and Engineering, Uppsala University, Uppsala, SwedenSelective Laser Sintering (SLS) has the potential to offer a more accurate alternative to current-practice manipulation of oral dosage forms for pediatric, geriatric, and dysphagia-suffering patient groups. In order to create the best possible dosage forms for these patient groups, an in-depth look into how a dosage forms geometry impacts the overall properties is essential. In this study, the impact of geometry on SLS manufactured oral dosage forms on the tablet’s microstructure, actual-to-theoretical volume, mass deviation, disintegration, and dissolution was investigated. Three different shapes; cylinder, hollow cylinder, and conical frustum with similar surface area (SA), as well as three cylinders with different diameters, were investigated. The results indicate that the geometry has an impact on the mass uniformity, resultant volume, disintegration, and dissolution properties of the tablets. The mass uniformity analysis of the tablets provided the most variation between tablets of different sizes, with more uniformity for tablets with similar SA-to-volume ratio (SA/V). When examining the actual-to-theoretical volume of the tablets, a greater variance between the actual and theoretical volumes for shapes with higher overall SA was observed. The values found are approximately 1.05 for the three differently sized cylinders, 1.23 for the conical frustum, and 1.44 for the hollow cylinder, following this trend. Disintegration data supported a link between SA/V and average disintegration time, observed with the tablet of the highest SA/V disintegrating in 12 s and the tablet with the lowest SA/V disintegrating in 58 s. Dissolution results also indicated a strong dependence on SA/V. Hence, when novel ways to produce oral dosage form tablets become available by additive manufacturing, such as SLS, both geometry and SA/V must be taken into consideration in the tablet design process to ensure appropriate release kinetics and dosing standards.https://www.frontiersin.org/articles/10.3389/fddev.2024.1358336/fullselective laser sintering (SLS)additive manufacturing (AM)surface area-to-volume ratio (SA/V)oral dosage formsgeometries |
| spellingShingle | Valerie R. Levine Christos S. Katsiotis Maria Strømme Julian Quodbach Jonas Lindh Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets Frontiers in Drug Delivery selective laser sintering (SLS) additive manufacturing (AM) surface area-to-volume ratio (SA/V) oral dosage forms geometries |
| title | Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets |
| title_full | Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets |
| title_fullStr | Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets |
| title_full_unstemmed | Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets |
| title_short | Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets |
| title_sort | geometry impact on fundamental properties of theophylline containing sls printed pharmaceutical tablets |
| topic | selective laser sintering (SLS) additive manufacturing (AM) surface area-to-volume ratio (SA/V) oral dosage forms geometries |
| url | https://www.frontiersin.org/articles/10.3389/fddev.2024.1358336/full |
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