Silver Stained Nucleolar Organizing regions [AgNOR] in Metastatic Carcinoma to peritoneal cavity
Background : AgNOR parameters are well known to pathologists as a proliferation marker with advantage over other proliferation markers of being cheaper, simpler and able to assess proliferation speed as well as state , AgNOR stainability was found to be well preserved in smears kept for up to 2 year...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2009-10-01
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| Series: | مجلة كلية الطب |
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| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1133 |
| _version_ | 1797367998733877248 |
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| author | Mazin J. Al-Baldawy |
| author_facet | Mazin J. Al-Baldawy |
| author_sort | Mazin J. Al-Baldawy |
| collection | DOAJ |
| description | Background : AgNOR parameters are well known to pathologists as a proliferation marker with advantage over other proliferation markers of being cheaper, simpler and able to assess
proliferation speed as well as state , AgNOR stainability was found to be well preserved in smears kept for up to 2 years , studies have shown that AgNOR values can serve as a useful
prognostic parameter and a marker for tumour progression in different carcinomas (1) This study was conducted to see the importance of AgNOR staining in the peritoneal fluid
cytopathological examination
Patient and Methods: It was a descriptive and prospective study conducted in Department of cytopathology in the medical city and Department of pathology n the medical college of
Baghdad University, from September 2003 to June 2007. AgNOR staining was performed on 50 peritoneal fluid specimens having malignant cells and 20 other peritoneal fluid specimens
as control cases
Results: AgNOR count, size and dispersion were normal in benign mesothelial cells (the proportion of cells with 1 or 2 AgNOR dots ranged from 32% to 98% with a median of 82%
and a mean of 80.7%, S.D. 15.4 the proportion of cells with clusters ranged from 0% to12% with a median of 0% and a mean of 1.3%, S.D. 2.5 ) , higher in the malignant cells(the
proportion of cells with 1 or 2 AgNOR dots ranged from 15% to 75% with a median of 30.5% and a mean of 28.9%, S.D. 21.1, the proportion of cells with clusters ranged from 23% to88%
with a median of 67.6% and a mean of 56.2%, S.D. 36.7 ). AgNOR counts in the malignant cells were significantly greater as compared with counts of normal mesothelial cells .
Conclusion: Typing of AgNOR count, size and dispersion was found to be an important marker in differentiation between normal mesothelial cells and malignant cells of metastatic
adenocarcinoma |
| first_indexed | 2024-03-08T17:26:12Z |
| format | Article |
| id | doaj.art-fb6f7b48c0bb40829dc9196f9bf4eec3 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:26:12Z |
| publishDate | 2009-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-fb6f7b48c0bb40829dc9196f9bf4eec32024-01-02T19:36:58ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572009-10-0151310.32007/jfacmedbagdad.v3312-315%Silver Stained Nucleolar Organizing regions [AgNOR] in Metastatic Carcinoma to peritoneal cavityMazin J. Al-Baldawy0Department of Pathology, College of Medicine – Baghdad UniversityBackground : AgNOR parameters are well known to pathologists as a proliferation marker with advantage over other proliferation markers of being cheaper, simpler and able to assess proliferation speed as well as state , AgNOR stainability was found to be well preserved in smears kept for up to 2 years , studies have shown that AgNOR values can serve as a useful prognostic parameter and a marker for tumour progression in different carcinomas (1) This study was conducted to see the importance of AgNOR staining in the peritoneal fluid cytopathological examination Patient and Methods: It was a descriptive and prospective study conducted in Department of cytopathology in the medical city and Department of pathology n the medical college of Baghdad University, from September 2003 to June 2007. AgNOR staining was performed on 50 peritoneal fluid specimens having malignant cells and 20 other peritoneal fluid specimens as control cases Results: AgNOR count, size and dispersion were normal in benign mesothelial cells (the proportion of cells with 1 or 2 AgNOR dots ranged from 32% to 98% with a median of 82% and a mean of 80.7%, S.D. 15.4 the proportion of cells with clusters ranged from 0% to12% with a median of 0% and a mean of 1.3%, S.D. 2.5 ) , higher in the malignant cells(the proportion of cells with 1 or 2 AgNOR dots ranged from 15% to 75% with a median of 30.5% and a mean of 28.9%, S.D. 21.1, the proportion of cells with clusters ranged from 23% to88% with a median of 67.6% and a mean of 56.2%, S.D. 36.7 ). AgNOR counts in the malignant cells were significantly greater as compared with counts of normal mesothelial cells . Conclusion: Typing of AgNOR count, size and dispersion was found to be an important marker in differentiation between normal mesothelial cells and malignant cells of metastatic adenocarcinomahttp://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1133AgNOR Argyrophilic nucleolus organizer region, Pap stain Papanicolau stain ,no. number ,vs. versus، NOR nucleolar organizing regions, S.D. Standard Deviation |
| spellingShingle | Mazin J. Al-Baldawy Silver Stained Nucleolar Organizing regions [AgNOR] in Metastatic Carcinoma to peritoneal cavity مجلة كلية الطب AgNOR Argyrophilic nucleolus organizer region, Pap stain Papanicolau stain ,no. number ,vs. versus، NOR nucleolar organizing regions, S.D. Standard Deviation |
| title | Silver Stained Nucleolar Organizing regions [AgNOR] in Metastatic Carcinoma to peritoneal cavity |
| title_full | Silver Stained Nucleolar Organizing regions [AgNOR] in Metastatic Carcinoma to peritoneal cavity |
| title_fullStr | Silver Stained Nucleolar Organizing regions [AgNOR] in Metastatic Carcinoma to peritoneal cavity |
| title_full_unstemmed | Silver Stained Nucleolar Organizing regions [AgNOR] in Metastatic Carcinoma to peritoneal cavity |
| title_short | Silver Stained Nucleolar Organizing regions [AgNOR] in Metastatic Carcinoma to peritoneal cavity |
| title_sort | silver stained nucleolar organizing regions agnor in metastatic carcinoma to peritoneal cavity |
| topic | AgNOR Argyrophilic nucleolus organizer region, Pap stain Papanicolau stain ,no. number ,vs. versus، NOR nucleolar organizing regions, S.D. Standard Deviation |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1133 |
| work_keys_str_mv | AT mazinjalbaldawy silverstainednucleolarorganizingregionsagnorinmetastaticcarcinomatoperitonealcavity |