Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification
Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/7/2144 |
| _version_ | 1797608294919962624 |
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| author | Jyotirmayee Talapatra Mamatha M. Reddy |
| author_facet | Jyotirmayee Talapatra Mamatha M. Reddy |
| author_sort | Jyotirmayee Talapatra |
| collection | DOAJ |
| description | Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid membrane biogenesis, generates the energy required for unrestricted cell proliferation, and some of the lipids act as signaling pathway mediators. In this review, we focus on the role of lipid metabolism in embryonal neoplasms with MYCN dysregulation. We specifically review lipid metabolic reactions in neuroblastoma, retinoblastoma, medulloblastoma, Wilms tumor, and rhabdomyosarcoma and the possibility of targeting lipid metabolism. Additionally, the regulation of lipid metabolism by the MYCN oncogene is discussed. |
| first_indexed | 2024-03-11T05:41:27Z |
| format | Article |
| id | doaj.art-fb70116bfb06407591c3e96c93dec54c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:41:27Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-fb70116bfb06407591c3e96c93dec54c2023-11-17T16:26:47ZengMDPI AGCancers2072-66942023-04-01157214410.3390/cancers15072144Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN AmplificationJyotirmayee Talapatra0Mamatha M. Reddy1The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Bhubaneswar 751024, IndiaThe Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Bhubaneswar 751024, IndiaTumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid membrane biogenesis, generates the energy required for unrestricted cell proliferation, and some of the lipids act as signaling pathway mediators. In this review, we focus on the role of lipid metabolism in embryonal neoplasms with MYCN dysregulation. We specifically review lipid metabolic reactions in neuroblastoma, retinoblastoma, medulloblastoma, Wilms tumor, and rhabdomyosarcoma and the possibility of targeting lipid metabolism. Additionally, the regulation of lipid metabolism by the MYCN oncogene is discussed.https://www.mdpi.com/2072-6694/15/7/2144cancerembryonal tumorsMYCNlipid metabolismtherapeutic targeting |
| spellingShingle | Jyotirmayee Talapatra Mamatha M. Reddy Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification Cancers cancer embryonal tumors MYCN lipid metabolism therapeutic targeting |
| title | Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification |
| title_full | Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification |
| title_fullStr | Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification |
| title_full_unstemmed | Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification |
| title_short | Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification |
| title_sort | lipid metabolic reprogramming in embryonal neoplasms with mycn amplification |
| topic | cancer embryonal tumors MYCN lipid metabolism therapeutic targeting |
| url | https://www.mdpi.com/2072-6694/15/7/2144 |
| work_keys_str_mv | AT jyotirmayeetalapatra lipidmetabolicreprogramminginembryonalneoplasmswithmycnamplification AT mamathamreddy lipidmetabolicreprogramminginembryonalneoplasmswithmycnamplification |