Therapeutic Potential of <i>Lindera obtusiloba</i>: Focus on Antioxidative and Pharmacological Properties
<i>Lindera obtusiloba</i> (LO) BLUME from the genus <i>Lindera</i> (Lauraceae) is a medicinal herb traditionally used in Southeast Asian countries. Indigenously, extracts of different parts of the plant have been used to improve blood circulation and treat allergy, inflammati...
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MDPI AG
2020-12-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/9/12/1765 |
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| author | Md Ezazul Haque Shofiul Azam Rengasamy Balakrishnan Mahbuba Akther In-Su Kim |
| author_facet | Md Ezazul Haque Shofiul Azam Rengasamy Balakrishnan Mahbuba Akther In-Su Kim |
| author_sort | Md Ezazul Haque |
| collection | DOAJ |
| description | <i>Lindera obtusiloba</i> (LO) BLUME from the genus <i>Lindera</i> (Lauraceae) is a medicinal herb traditionally used in Southeast Asian countries. Indigenously, extracts of different parts of the plant have been used to improve blood circulation and treat allergy, inflammation, rheumatism, and liver diseases. LO is a rich source of therapeutically beneficial antioxidative phytochemicals, such as flavonoids, butenolides, lignans and neolignans. Moreover, recent studies have unravelled the pharmacological properties of several newly found active constituents of LO, such as anti-inflammatory antioxidants (+)-syringaresinol, linderin A, anti-atherosclerotic antioxidant (+)-episesamin, anti-melanogenic antioxidants quercitrin and afzelin, cytotoxic 2-(1-methoxy-11-dodecenyl)-penta-2,4-dien-4-olide, (2<i>Z</i>,3<i>S</i>,4<i>S</i>)-2-(11-dodecenylidene)-3-hydroxy-4-methyl butanolide, anti-allergic koaburaside, (6-hydroxyphenyl)-1-O-beta-d-glucopyranoside and 2,6-dimethoxy-4-hydroxyphenyl-1-O-beta-<span style="font-variant: small-caps;">d</span>-glucopyranoside and the antiplatelet-activity compound Secolincomolide A. These findings demonstrate that LO can be a potential source of antioxidants and other prospective therapeutically active constituents that can lead to the development of oxidative stress-mediated diseases, such as cardiovascular disorders, neurodegenerative disorders, allergies, inflammation, hepatotoxicity, and cancer. Here, the antioxidant properties of different species of <i>Lindera</i> genus are discussed briefly. The traditional use, phytochemistry, antioxidative and pharmacological properties of LO are also considered to help researchers screen potential lead compounds and design and develop future therapeutic agents to treat oxidative stress-mediated disorders. |
| first_indexed | 2024-03-10T14:07:24Z |
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| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T14:07:24Z |
| publishDate | 2020-12-01 |
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| series | Plants |
| spelling | doaj.art-fb7235d5f70043e8b4cd0a406143f7e12023-11-21T00:37:30ZengMDPI AGPlants2223-77472020-12-01912176510.3390/plants9121765Therapeutic Potential of <i>Lindera obtusiloba</i>: Focus on Antioxidative and Pharmacological PropertiesMd Ezazul Haque0Shofiul Azam1Rengasamy Balakrishnan2Mahbuba Akther3In-Su Kim4Department of Applied Life Science, Graduate School, Konkuk University, Chungju 27478, KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju 27478, KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju 27478, KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju 27478, KoreaDepartment of Biotechnology, College of Biomedical and Health Science, Research Institute of Inflammatory Disease (RID), Konkuk University, Chungju 27478, Korea<i>Lindera obtusiloba</i> (LO) BLUME from the genus <i>Lindera</i> (Lauraceae) is a medicinal herb traditionally used in Southeast Asian countries. Indigenously, extracts of different parts of the plant have been used to improve blood circulation and treat allergy, inflammation, rheumatism, and liver diseases. LO is a rich source of therapeutically beneficial antioxidative phytochemicals, such as flavonoids, butenolides, lignans and neolignans. Moreover, recent studies have unravelled the pharmacological properties of several newly found active constituents of LO, such as anti-inflammatory antioxidants (+)-syringaresinol, linderin A, anti-atherosclerotic antioxidant (+)-episesamin, anti-melanogenic antioxidants quercitrin and afzelin, cytotoxic 2-(1-methoxy-11-dodecenyl)-penta-2,4-dien-4-olide, (2<i>Z</i>,3<i>S</i>,4<i>S</i>)-2-(11-dodecenylidene)-3-hydroxy-4-methyl butanolide, anti-allergic koaburaside, (6-hydroxyphenyl)-1-O-beta-d-glucopyranoside and 2,6-dimethoxy-4-hydroxyphenyl-1-O-beta-<span style="font-variant: small-caps;">d</span>-glucopyranoside and the antiplatelet-activity compound Secolincomolide A. These findings demonstrate that LO can be a potential source of antioxidants and other prospective therapeutically active constituents that can lead to the development of oxidative stress-mediated diseases, such as cardiovascular disorders, neurodegenerative disorders, allergies, inflammation, hepatotoxicity, and cancer. Here, the antioxidant properties of different species of <i>Lindera</i> genus are discussed briefly. The traditional use, phytochemistry, antioxidative and pharmacological properties of LO are also considered to help researchers screen potential lead compounds and design and develop future therapeutic agents to treat oxidative stress-mediated disorders.https://www.mdpi.com/2223-7747/9/12/1765<i>Lindera obtusiloba</i>antioxidantoxidative stressanti-canceranti-inflammatoryanti-platelet |
| spellingShingle | Md Ezazul Haque Shofiul Azam Rengasamy Balakrishnan Mahbuba Akther In-Su Kim Therapeutic Potential of <i>Lindera obtusiloba</i>: Focus on Antioxidative and Pharmacological Properties Plants <i>Lindera obtusiloba</i> antioxidant oxidative stress anti-cancer anti-inflammatory anti-platelet |
| title | Therapeutic Potential of <i>Lindera obtusiloba</i>: Focus on Antioxidative and Pharmacological Properties |
| title_full | Therapeutic Potential of <i>Lindera obtusiloba</i>: Focus on Antioxidative and Pharmacological Properties |
| title_fullStr | Therapeutic Potential of <i>Lindera obtusiloba</i>: Focus on Antioxidative and Pharmacological Properties |
| title_full_unstemmed | Therapeutic Potential of <i>Lindera obtusiloba</i>: Focus on Antioxidative and Pharmacological Properties |
| title_short | Therapeutic Potential of <i>Lindera obtusiloba</i>: Focus on Antioxidative and Pharmacological Properties |
| title_sort | therapeutic potential of i lindera obtusiloba i focus on antioxidative and pharmacological properties |
| topic | <i>Lindera obtusiloba</i> antioxidant oxidative stress anti-cancer anti-inflammatory anti-platelet |
| url | https://www.mdpi.com/2223-7747/9/12/1765 |
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