Big data and reference intervals: rationale, current practices, harmonization and standardization prerequisites and future perspectives of indirect determination of reference intervals using routine data

Reference intervals are commonly used as a decision-making tool. In this review, we provide an overview on “big data” and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, including harmonization and stand...

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Bibliographic Details
Main Authors: Martinez-Sanchez Luisa, Marques-Garcia Fernando, Ozarda Yesim, Blanco Albert, Brouwer Nannette, Canalias Francesca, Cobbaert Christa, Thelen Marc, den Elzen Wendy
Format: Article
Language:English
Published: De Gruyter 2020-08-01
Series:Advances in Laboratory Medicine
Subjects:
Online Access:https://doi.org/10.1515/almed-2020-0034