Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil
Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, cholesterol and stearylamine were used to prepare non...
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.627817/full |
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| author | Zheng Zhang Jun Yang Qing Yang Qing Yang Guangyong Tian Guangyong Tian Zhong-Kai Cui Zhong-Kai Cui Zhong-Kai Cui |
| author_facet | Zheng Zhang Jun Yang Qing Yang Qing Yang Guangyong Tian Guangyong Tian Zhong-Kai Cui Zhong-Kai Cui Zhong-Kai Cui |
| author_sort | Zheng Zhang |
| collection | DOAJ |
| description | Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, cholesterol and stearylamine were used to prepare non-phospholipid liposomes (sterosomes) as a pesticide nanocarrier, and were characterized with field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) spectrometer, size distribution, and ζ-potential. The results showed sterosomes were successfully loaded with cymoxanil. The loading efficiency and the drug-to-lipid ratio were 92.6% and 0.0761, respectively. Prolonged drug release was obtained for 3 days, improving the short duration of the drug itself. The addition of cymoxanil-loaded sterosomes in culture medium effectively inhibited the growth of yeast cells, which serve as model fungal targets. Sterosomes as nanocarriers significantly improved the stability and efficacy of cymoxanil, thus introducing practical and economically desirable strategies for the preparation of novel pesticide formulations. |
| first_indexed | 2024-12-13T15:26:11Z |
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| id | doaj.art-fb72779fd3b34a9ebcfc0c35f9873fba |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-13T15:26:11Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-fb72779fd3b34a9ebcfc0c35f9873fba2022-12-21T23:40:21ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-03-01810.3389/fmolb.2021.627817627817Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide CymoxanilZheng Zhang0Jun Yang1Qing Yang2Qing Yang3Guangyong Tian4Guangyong Tian5Zhong-Kai Cui6Zhong-Kai Cui7Zhong-Kai Cui8State Key Laboratory for Biology of Plant Diseases and Insect Pests, School of Bioengineering, Dalian University of Technology, Dalian, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, School of Bioengineering, Dalian University of Technology, Dalian, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, School of Bioengineering, Dalian University of Technology, Dalian, ChinaInstitute of Plant Protection and Shenzhen Agricultural Genome Research Institute, Chinese Academy of Agricultural Sciences, Beijing, ChinaGuangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Southern Medical University, Guangzhou, ChinaDepartment of Otorhinolaryngology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Southern Medical University, Guangzhou, ChinaDepartment of Otorhinolaryngology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaLiposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, cholesterol and stearylamine were used to prepare non-phospholipid liposomes (sterosomes) as a pesticide nanocarrier, and were characterized with field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) spectrometer, size distribution, and ζ-potential. The results showed sterosomes were successfully loaded with cymoxanil. The loading efficiency and the drug-to-lipid ratio were 92.6% and 0.0761, respectively. Prolonged drug release was obtained for 3 days, improving the short duration of the drug itself. The addition of cymoxanil-loaded sterosomes in culture medium effectively inhibited the growth of yeast cells, which serve as model fungal targets. Sterosomes as nanocarriers significantly improved the stability and efficacy of cymoxanil, thus introducing practical and economically desirable strategies for the preparation of novel pesticide formulations.https://www.frontiersin.org/articles/10.3389/fmolb.2021.627817/fullnon-phospholipid liposomesfungicidesustained releasenanotechnology applicationscymoxanil |
| spellingShingle | Zheng Zhang Jun Yang Qing Yang Qing Yang Guangyong Tian Guangyong Tian Zhong-Kai Cui Zhong-Kai Cui Zhong-Kai Cui Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil Frontiers in Molecular Biosciences non-phospholipid liposomes fungicide sustained release nanotechnology applications cymoxanil |
| title | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
| title_full | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
| title_fullStr | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
| title_full_unstemmed | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
| title_short | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
| title_sort | fabrication of non phospholipid liposomal nanocarrier for sustained release of the fungicide cymoxanil |
| topic | non-phospholipid liposomes fungicide sustained release nanotechnology applications cymoxanil |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.627817/full |
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