Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study
Abstract Background Low muscle mass likely results in reduced capacity for glucose disposal, leading to a significant but under-appreciated contribution to increasing the risk of diabetes. But few prospective studies have investigated the association between the loss of muscle mass and the occurrenc...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
|
| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-023-01027-8 |
| _version_ | 1797863990169174016 |
|---|---|
| author | Yiting Xu Tingting Hu Yun Shen Yufei Wang Yuqian Bao Xiaojing Ma |
| author_facet | Yiting Xu Tingting Hu Yun Shen Yufei Wang Yuqian Bao Xiaojing Ma |
| author_sort | Yiting Xu |
| collection | DOAJ |
| description | Abstract Background Low muscle mass likely results in reduced capacity for glucose disposal, leading to a significant but under-appreciated contribution to increasing the risk of diabetes. But few prospective studies have investigated the association between the loss of muscle mass and the occurrence of diabetes. We aimed to investigate whether short-term changes in muscle mass affect the incidence of diabetes in a Chinese population. Methods This study included 1275 individuals without evident diabetes at baseline. In the baseline and re-examination, individuals completed the risk factors survey and underwent body composition measurement. Muscle mass index was defined as the percentage skeletal muscle mass, which was measured by an automatic bioelectric analyzer. Results After a median follow-up of 2.1 years, 142 individuals developed diabetes (11.1%). There was an inverse association between basal skeletal muscle mass index and the risk of diabetes in participants with impaired glucose regulation but not in those with normal glucose tolerance. Multivariate-adjusted hazard ratios for the risk of developing diabetes were 0.85 (95% CI: 0.74–0.98) and 1.15 (95% CI: 0.98–1.34), respectively. Furthermore, Cox regression analysis revealed that a two-year change in skeletal muscle mass was also inversely associated with the incidence of diabetes in both participants with normal glucose tolerance and with impaired glucose regulation (HR: 0.76, 95% CI: 0.65–0.89; HR: 0.81, 95% CI: 0.71–0.91). Conclusions These findings emphasized the importance of early detection and control of muscle mass loss for the prevention of diabetes. |
| first_indexed | 2024-04-09T22:45:27Z |
| format | Article |
| id | doaj.art-fb72e1eafce04a4588fbc6a723d2b785 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-09T22:45:27Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-fb72e1eafce04a4588fbc6a723d2b7852023-03-22T11:56:05ZengBMCDiabetology & Metabolic Syndrome1758-59962023-03-011511810.1186/s13098-023-01027-8Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort studyYiting Xu0Tingting Hu1Yun Shen2Yufei Wang3Yuqian Bao4Xiaojing Ma5Department of Endocrinology and Metabolism, Sixth People’s Hospital Affiliated to Shanghai JiaoTong University School of Medicine; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Sixth People’s Hospital Affiliated to Shanghai JiaoTong University School of Medicine; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Sixth People’s Hospital Affiliated to Shanghai JiaoTong University School of Medicine; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Sixth People’s Hospital Affiliated to Shanghai JiaoTong University School of Medicine; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Sixth People’s Hospital Affiliated to Shanghai JiaoTong University School of Medicine; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and Metabolism, Sixth People’s Hospital Affiliated to Shanghai JiaoTong University School of Medicine; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes MellitusAbstract Background Low muscle mass likely results in reduced capacity for glucose disposal, leading to a significant but under-appreciated contribution to increasing the risk of diabetes. But few prospective studies have investigated the association between the loss of muscle mass and the occurrence of diabetes. We aimed to investigate whether short-term changes in muscle mass affect the incidence of diabetes in a Chinese population. Methods This study included 1275 individuals without evident diabetes at baseline. In the baseline and re-examination, individuals completed the risk factors survey and underwent body composition measurement. Muscle mass index was defined as the percentage skeletal muscle mass, which was measured by an automatic bioelectric analyzer. Results After a median follow-up of 2.1 years, 142 individuals developed diabetes (11.1%). There was an inverse association between basal skeletal muscle mass index and the risk of diabetes in participants with impaired glucose regulation but not in those with normal glucose tolerance. Multivariate-adjusted hazard ratios for the risk of developing diabetes were 0.85 (95% CI: 0.74–0.98) and 1.15 (95% CI: 0.98–1.34), respectively. Furthermore, Cox regression analysis revealed that a two-year change in skeletal muscle mass was also inversely associated with the incidence of diabetes in both participants with normal glucose tolerance and with impaired glucose regulation (HR: 0.76, 95% CI: 0.65–0.89; HR: 0.81, 95% CI: 0.71–0.91). Conclusions These findings emphasized the importance of early detection and control of muscle mass loss for the prevention of diabetes.https://doi.org/10.1186/s13098-023-01027-8Skeletal muscle massDiabetes occurrenceSarcopeniaMuscle mass lossImpaired glucose regulation |
| spellingShingle | Yiting Xu Tingting Hu Yun Shen Yufei Wang Yuqian Bao Xiaojing Ma Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study Diabetology & Metabolic Syndrome Skeletal muscle mass Diabetes occurrence Sarcopenia Muscle mass loss Impaired glucose regulation |
| title | Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study |
| title_full | Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study |
| title_fullStr | Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study |
| title_full_unstemmed | Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study |
| title_short | Association of skeletal muscle mass and its change with diabetes occurrence: a population-based cohort study |
| title_sort | association of skeletal muscle mass and its change with diabetes occurrence a population based cohort study |
| topic | Skeletal muscle mass Diabetes occurrence Sarcopenia Muscle mass loss Impaired glucose regulation |
| url | https://doi.org/10.1186/s13098-023-01027-8 |
| work_keys_str_mv | AT yitingxu associationofskeletalmusclemassanditschangewithdiabetesoccurrenceapopulationbasedcohortstudy AT tingtinghu associationofskeletalmusclemassanditschangewithdiabetesoccurrenceapopulationbasedcohortstudy AT yunshen associationofskeletalmusclemassanditschangewithdiabetesoccurrenceapopulationbasedcohortstudy AT yufeiwang associationofskeletalmusclemassanditschangewithdiabetesoccurrenceapopulationbasedcohortstudy AT yuqianbao associationofskeletalmusclemassanditschangewithdiabetesoccurrenceapopulationbasedcohortstudy AT xiaojingma associationofskeletalmusclemassanditschangewithdiabetesoccurrenceapopulationbasedcohortstudy |