Retrospective Examination of Patients Diagnosed with Aortic Dissection in the Emergency Department and Undergoing Thiol / Disulfide Homeostasis
INTRODUCTION: To study changes in dynamic thiol/disulfide homeostasis (TDH) in patients with acute aortic dissection (AAD). METHODS: In our study, the medical records of patients who applied to Ankara Atatürk Training and Research Hospital between January 2015- January 2018 and were found to have AA...
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| Format: | Article |
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Ankara Yildirim Beyazit University
2021-03-01
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| Series: | Ankara Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-70037 |
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| author | Nazlı Görmeli Kurt Servan Gökhan Ozcan EREL Celal Güneş Çağdaş Yıldırım Ayhan Ozhasenekler Fatih Ahmet Kahraman |
| author_facet | Nazlı Görmeli Kurt Servan Gökhan Ozcan EREL Celal Güneş Çağdaş Yıldırım Ayhan Ozhasenekler Fatih Ahmet Kahraman |
| author_sort | Nazlı Görmeli Kurt |
| collection | DOAJ |
| description | INTRODUCTION: To study changes in dynamic thiol/disulfide homeostasis (TDH) in patients with acute aortic dissection (AAD). METHODS: In our study, the medical records of patients who applied to Ankara Atatürk Training and Research Hospital between January 2015- January 2018 and were found to have AAD on computed tomography of the thorax were retrospectively reviewed. There were two groups in the study, one AAD group, and the other healthy volunteers' group. First, thiol and disulfide levels were determined with the spectrophotometric method defined by Erel and Neşelioğlu, natural thiol (NT), total thiol (TT), and disulfide (D) levels, and their ratios were calculated (index 1: D / NT, index 2: D / TT, index 3: NT / TT). We compared these two groups in terms of Oxidative stress parameters. RESULTS: A total of 40 patients with AAD and 38 age-matched healthy volunteers were included in this study. There was no significant difference between the two groups in terms of gender and age (p=0.923, p=0.401, respectively). The AAD group had significantly lower natural thiol and total thiol (p<0.001), but disulfide levels were similar (p=0.360). Oxidative stress parameters were not statistically significant in terms of mortality. DISCUSSION AND CONCLUSION: We found significantly lower thiol/disulfide homeostasis in patients with AAD, particularly native thiol and total thiol. We think that oxidative stress theory may play a role in the pathophysiology of AAD and oxidative stress parameters may guide the diagnosis. |
| first_indexed | 2024-04-10T12:40:11Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2148-4570 |
| language | English |
| last_indexed | 2024-04-10T12:40:11Z |
| publishDate | 2021-03-01 |
| publisher | Ankara Yildirim Beyazit University |
| record_format | Article |
| series | Ankara Medical Journal |
| spelling | doaj.art-fb73fcc744e54be8a355914ab850f4d52023-02-15T16:14:23ZengAnkara Yildirim Beyazit UniversityAnkara Medical Journal2148-45702021-03-0121112413310.5505/amj.2021.70037AMJ-70037Retrospective Examination of Patients Diagnosed with Aortic Dissection in the Emergency Department and Undergoing Thiol / Disulfide HomeostasisNazlı Görmeli Kurt0Servan Gökhan1Ozcan EREL2Celal Güneş3Çağdaş Yıldırım4Ayhan Ozhasenekler5Fatih Ahmet Kahraman6Department of Emergency Medicine, Ankara City Hospital, 06800, Ankara, TurkeyDepartment of Emergency Medicine, School of Medicine, Ankara Yıldırım Beyazıt University, 06800, Ankara, TurkeyDepartment of Biochemistry, School of Medicine, Ankara Yıldırım Beyazıt University, 06800, Ankara, TurkeyBatman State Hospital, Department of Emergency Medicine, Batman, TurkeyDepartment of Emergency Medicine, School of Medicine, Ankara Yıldırım Beyazıt University, 06800, Ankara, TurkeyDepartment of Emergency Medicine, School of Medicine, Ankara Yıldırım Beyazıt University, 06800, Ankara, TurkeyDepartment of Emergency Medicine, School of Medicine, Ankara Yıldırım Beyazıt University, 06800, Ankara, TurkeyINTRODUCTION: To study changes in dynamic thiol/disulfide homeostasis (TDH) in patients with acute aortic dissection (AAD). METHODS: In our study, the medical records of patients who applied to Ankara Atatürk Training and Research Hospital between January 2015- January 2018 and were found to have AAD on computed tomography of the thorax were retrospectively reviewed. There were two groups in the study, one AAD group, and the other healthy volunteers' group. First, thiol and disulfide levels were determined with the spectrophotometric method defined by Erel and Neşelioğlu, natural thiol (NT), total thiol (TT), and disulfide (D) levels, and their ratios were calculated (index 1: D / NT, index 2: D / TT, index 3: NT / TT). We compared these two groups in terms of Oxidative stress parameters. RESULTS: A total of 40 patients with AAD and 38 age-matched healthy volunteers were included in this study. There was no significant difference between the two groups in terms of gender and age (p=0.923, p=0.401, respectively). The AAD group had significantly lower natural thiol and total thiol (p<0.001), but disulfide levels were similar (p=0.360). Oxidative stress parameters were not statistically significant in terms of mortality. DISCUSSION AND CONCLUSION: We found significantly lower thiol/disulfide homeostasis in patients with AAD, particularly native thiol and total thiol. We think that oxidative stress theory may play a role in the pathophysiology of AAD and oxidative stress parameters may guide the diagnosis.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-70037aneurysmdissectionoxidative stresssulfhydryl compoundsdisulfides. |
| spellingShingle | Nazlı Görmeli Kurt Servan Gökhan Ozcan EREL Celal Güneş Çağdaş Yıldırım Ayhan Ozhasenekler Fatih Ahmet Kahraman Retrospective Examination of Patients Diagnosed with Aortic Dissection in the Emergency Department and Undergoing Thiol / Disulfide Homeostasis Ankara Medical Journal aneurysm dissection oxidative stress sulfhydryl compounds disulfides. |
| title | Retrospective Examination of Patients Diagnosed with Aortic Dissection in the Emergency Department and Undergoing Thiol / Disulfide Homeostasis |
| title_full | Retrospective Examination of Patients Diagnosed with Aortic Dissection in the Emergency Department and Undergoing Thiol / Disulfide Homeostasis |
| title_fullStr | Retrospective Examination of Patients Diagnosed with Aortic Dissection in the Emergency Department and Undergoing Thiol / Disulfide Homeostasis |
| title_full_unstemmed | Retrospective Examination of Patients Diagnosed with Aortic Dissection in the Emergency Department and Undergoing Thiol / Disulfide Homeostasis |
| title_short | Retrospective Examination of Patients Diagnosed with Aortic Dissection in the Emergency Department and Undergoing Thiol / Disulfide Homeostasis |
| title_sort | retrospective examination of patients diagnosed with aortic dissection in the emergency department and undergoing thiol disulfide homeostasis |
| topic | aneurysm dissection oxidative stress sulfhydryl compounds disulfides. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-70037 |
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