Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils

Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils

Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose secretion does not follow the classical endoplasmic reticulum-to-Golgi pathway, and for which a canonical mechanism of secretion remains to be established. Neutrophils are essential players against bac...

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Bibliographic Details
Main Authors: Leonardo Iula, Irene A. Keitelman, Florencia Sabbione, Federico Fuentes, Mauricio Guzman, Jeremías Gastón Galletti, Pehuén Pereyra Gerber, Matías Ostrowski, Jorge R. Geffner, Carolina C. Jancic, Analía S. Trevani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
neutrophil
autophagy
interleukin-1β
unconventional secretion
serine proteases
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00269/full

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